Activation of ET(A) receptors is partially responsible for the rapid increase in haematocrit induced by bacterial lipopolysaccharide in the rat.
Life Sci
; 60(19): PL 271-6, 1997.
Article
em En
| MEDLINE
| ID: mdl-9129129
ABSTRACT
It is believed that changes in the production and release of endothelin-1 (ET-1) are mediated over prolonged periods, and, therefore, that it is unlikely that ET-1 mediates rapid responses within the circulation. Here we show that ET-1 is involved in the rapid changes produced by injection of LPS in vivo. In anaesthetised rats, a bolus of LPS induced an increase in haematocrit and a fall in blood pressure within 10 min. The increase in haematocrit was reduced by administration of antagonists selective for endothelin ET(A) receptors, while the accompanying decrease in MAP was potentiated. Thus, activation of ET(A) receptors is partially responsible for the rapid increase in haematocrit seen in this model. This clearly demonstrates that ET-1 can act as a rapid responder to acute cardiovascular challenges.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Azepinas
/
Lipopolissacarídeos
/
Receptores de Endotelina
/
Hematócrito
/
Indóis
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Life Sci
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Reino Unido