Vitamin B12 levels of cerebrospinal fluid in patients with a variety of neurological disorders.
J Nutr Sci Vitaminol (Tokyo)
; 23(4): 299-304, 1977.
Article
em En
| MEDLINE
| ID: mdl-915560
ABSTRACT
The vitamin B12 levels of cerebrospinal fluid were assayed microbiologically (Lactobacillus leichmannii method) using samples from 44 patients with various neurological disorders, 4 patients with megaloblastic anemia and 34 controls. Twenty-seven controls that did not receive vitamin B12 showed a mean cerebrospinal fluid vitamin B12 level of 21.5 pg/ml (range 0-60). No decrease in cerebrospinal fluid vitamin B12 level was seen in patients with subacute myelo-optico-neuropathy (SMON). High levels of cerebrospinal fluid vitamin B12 were observed only in the patients receiving long term administration of the vitamin. Intrathecal administration of vitamin B12 caused only a slight increase in serum vitamin B12 level after four hours. The existence of blood brain barrier for vitamin B12 was suggested.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vitamina B 12
/
Doenças do Sistema Nervoso Central
Limite:
Humans
Idioma:
En
Revista:
J Nutr Sci Vitaminol (Tokyo)
Ano de publicação:
1977
Tipo de documento:
Article