Fetal hemoglobin in patients with chronic renal disease.
Braz J Med Biol Res
; 29(8): 1001-4, 1996 Aug.
Article
em En
| MEDLINE
| ID: mdl-9181081
ABSTRACT
To investigate-whether hemoglobin (Hb) synthesis is affected by different treatment protocols used for end-stage renal disease, we analyzed the electrophoretic pattern of hemoglobin in 136 adult patients with chronic renal failure. Forty-seven patients were not in a dialysis program (ND), 29 individuals were on continuous ambulatory peritoneal dialysis (CAPD), 33 patients were on hemodialysis (HD), and 27 subjects had received a kidney transplant (KT). We found 3.6% hemoglobin C, 1.4% hemoglobin S and 3.6% B-thalassemia minor as reported in other studies of Brazilian patients. In addition, we found increased fetal hemoglobin (Hb F) levels in 7.4% of the patients which contrasts with the reported 0.01% prevalence rate of hereditary persistence of Hb F in Brazil. Seven out of ten patients with elevated Hb F belonged to either the CAPD or the KT group. We postulate that stress erythropoiesis is probably the mechanism responsible for the Hb F increase in these patients. However, properly designed clinical studies are still necessary to clarify these questions.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hemoglobina Fetal
/
Falência Renal Crônica
Tipo de estudo:
Guideline
/
Risk_factors_studies
Limite:
Adult
/
Humans
Idioma:
En
Revista:
Braz J Med Biol Res
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Brasil