Pituitary hormones modulate cell-cell interactions between thymocytes and thymic epithelial cells.
J Neuroimmunol
; 76(1-2): 39-49, 1997 Jun.
Article
em En
| MEDLINE
| ID: mdl-9184631
ABSTRACT
The thymic microenvironment plays a key role in the intrathymic T-cell differentiation. It is composed of a tridimensional network of epithelial cells whose physiology is controlled by extrinsic circuits such as neuroendocrine axes. Herein we show that the expression of extracellular matrix ligands and receptor by cultured thymic epithelial cells is upregulated by prolactin (PRL) and growth hormone (GH), the latter apparently occurring via insulin-like growth factor I (IGF-I). Thymocyte release from the lymphoepithelial complexes, thymic nurse cells, as well as the reconstitution of these complexes are enhanced by PRL, GH or IGF-I. Treatment of a mouse thymic epithelial cell line with these hormones induced an increase in thymocyte adhesion, an effect significantly prevented in the presence of antibodies to fibronectin, laminin or respective receptors VLA-5 and VLA-6. Our data suggest that the in vitro changes in thymocyte/thymic epithelial cell interactions induced by pituitary hormones are partially mediated by the enhancement of extracellular matrix ligands and receptors.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Prolactina
/
Timo
/
Hormônio do Crescimento
/
Linfócitos T
/
Comunicação Celular
Limite:
Animals
Idioma:
En
Revista:
J Neuroimmunol
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Brasil