Elevated platelet factor 4 and beta-thromboglobulin plasma levels in depressed patients with ischemic heart disease.
Biol Psychiatry
; 42(4): 290-5, 1997 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-9270907
ABSTRACT
Clinical depression has recently been recognized as an independent risk factor for cardiac mortality in patients after myocardial infarction. The underlying mechanisms of this increased mortality remain unclear. This study investigated the hypothesis that patients suffering from ischemic heart disease (IHD) and depression concurrently may have abnormal platelet activation resulting in an increased risk of thrombosis. Platelet factor 4 (PF4) and beta-thromboglobulin (beta-TG) were measured in young healthy control subjects, in nondepressed patients with IHD, and in depressed patients with IHD. Mean PF4 and beta-TG plasma levels in the IHD group with depression were found to be significantly higher than those of the control and IHD groups. This increase was not related to age, gender, racial difference, aspirin use, or severity of cardiac disease. This finding suggests that in depressed patients with IHD there is greater platelet activation, and may indicate an increased risk of thrombotic complications.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Beta-Tromboglobulina
/
Fator Plaquetário 4
/
Isquemia Miocárdica
/
Transtorno Depressivo
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Biol Psychiatry
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Estados Unidos