Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants.
Science
; 277(5330): 1313-6, 1997 Aug 29.
Article
em En
| MEDLINE
| ID: mdl-9271578
ABSTRACT
The SGS1 gene of yeast encodes a DNA helicase with homology to the human WRN gene. Mutations in WRN result in Werner's syndrome, a disease with symptoms resembling premature aging. Mutation of SGS1 is shown to cause premature aging in yeast mother cells on the basis of a shortened life-span and the aging-induced phenotypes of sterility and redistribution of the Sir3 silencing protein from telomeres to the nucleolus. Further, in old sgs1 cells the nucleolus is enlarged and fragmented-changes that also occur in old wild-type cells. These findings suggest a conserved mechanism of cellular aging that may be related to nucleolar structure.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Saccharomyces cerevisiae
/
Nucléolo Celular
/
Senescência Celular
/
DNA Helicases
/
Proteínas Reguladoras de Informação Silenciosa de Saccharomyces cerevisiae
Limite:
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Estados Unidos