Deletion of the long arm of chromosome 7 in myelomonocytic leukemia with bone marrow eosinophilia.
Cancer Genet Cytogenet
; 97(2): 122-4, 1997 Sep.
Article
em En
| MEDLINE
| ID: mdl-9283595
ABSTRACT
We report a 62-year-old man with acute myelomonocytic leukemia with bone marrow eosinophilia (M4Eo), and a deletion of the long arm of chromosome 7. The patient presented with pancytopenia, which shortly after evolved to overt leukemia. There was no response to the daunorubicin-cytosine arabinoside (Ara-C) regimen, and a remission achieved with amsacrine (AMSA)-Ara-C lasted only for a short time. On relapse, a peculiar skin rash accompanied the hematologic picture. While ANLL with chromosome 7 abnormalities usually carries adverse prognosis, patients with M4Eo (which is usually associated with chromosome 16 abnormalities) do better. The patient described here examplifies that M4Eo may be associated with del(7)(q22), and that it is the chromosomal abnormality rather than the type of leukemia that might determine the clinical outcome.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromossomos Humanos Par 7
/
Leucemia Mielomonocítica Aguda
/
Aberrações Cromossômicas
/
Deleção Cromossômica
/
Eosinofilia
Tipo de estudo:
Prognostic_studies
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Cancer Genet Cytogenet
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Israel