A retrospective analysis of the efficacy and safety of metformin in the African-American patient.
J Natl Med Assoc
; 89(11): 728-30, 1997 Nov.
Article
em En
| MEDLINE
| ID: mdl-9375476
ABSTRACT
A retrospective analysis was conducted to determine the effects of metformin on glycosylated hemoglobin (HbA1c), body weight, and adverse events in an African-American population. Thirty-six patients who were receiving combination therapy with metformin and either a sulfonylurea or insulin were identified from a hospital pharmacy database. Nineteen patients met the criteria for efficacy analysis. The combination of metformin with either a sulfonylurea or insulin resulted in a decrease of the average HbA1c from a baseline of 10.07% to 7.92% (delta = 2.15%). The effect of combination therapy on weight was variable; however, twice as many patients lost weight compared with those who gained weight. Metformin appeared to be well-tolerated, with gastrointestinal symptoms being the most commonly reported adverse events.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peso Corporal
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Hemoglobinas Glicadas
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População Negra
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Diabetes Mellitus Tipo 2
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Hipoglicemiantes
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Metformina
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Natl Med Assoc
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Estados Unidos