Current concepts on the diagnostic use of MIBG in children.
J Nucl Med
; 39(4): 679-88, 1998 Apr.
Article
em En
| MEDLINE
| ID: mdl-9544682
ABSTRACT
Metaiodobenzylguanidine (MIBG) was developed 18 yr ago for scintigraphic imaging of the adrenomedullary tumors pheochromocytoma and neuroblastoma. Many studies have shown the usefulness of this agent for the management of patients with neuroblastoma or pheochromocytoma, and the 131I-labeled form was recently approved by the Food and Drug Administration for use in the U.S. This article summarizes our current concepts on the diagnostic use of MIBG in children. The radioisotopes available for labeling of MIBG and related compounds, the dosimetry, metabolism and mechanisms of uptake and retention are discussed. Our protocols for imaging both 131I-MIBG and 123I-MIBG, along with the normal distribution of these compounds, are reviewed. The use of MIBG for the management of neuroblastoma, and comparisons with other radiotracers available for imaging neuroblastomas are also addressed.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Feocromocitoma
/
Neoplasias das Glândulas Suprarrenais
/
Compostos Radiofarmacêuticos
/
3-Iodobenzilguanidina
/
Radioisótopos do Iodo
/
Neuroblastoma
Tipo de estudo:
Diagnostic_studies
/
Guideline
Limite:
Child
/
Child, preschool
/
Humans
/
Infant
/
Newborn
Idioma:
En
Revista:
J Nucl Med
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Estados Unidos