99mTc-MIBI, 99mTc-tetrofosmin and 99mTc-Q12 in vitro and in vivo.
Nucl Med Biol
; 25(3): 233-40, 1998 Apr.
Article
em En
| MEDLINE
| ID: mdl-9620628
ABSTRACT
The aim of this study was to compare uptake of 99mTc-MIBI, 99mTc-tetrofosmin and 99mTc-Q12 in vitro and biodistribution in vivo in rats. In vitro, uptake decreased in the order MIBI-->tetrofosmin-->Q12. Uptake of MIBI and tetrofosmin, but not of Q12, in cultured tumor cells was dependent on the plasma membrane and mitochondrial potential. In vivo, heart uptake of all three compounds was high and stable. Tumor uptake decreased in the order MIBI-->Q12-->tetrofosmin and the tumor/blood ratio in the order MIBI-->tetrofosmin-->Q12.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Organofosforados
/
Compostos de Organotecnécio
/
Tecnécio Tc 99m Sestamibi
/
Compostos Radiofarmacêuticos
/
Furanos
Limite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Nucl Med Biol
Assunto da revista:
BIOLOGIA
/
MEDICINA NUCLEAR
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Holanda