A new model of endovascularly induced renal artery stenosis in normocholesterolemic versus hypercholesterolemic rabbits.
Invest Radiol
; 33(6): 322-8, 1998 Jun.
Article
em En
| MEDLINE
| ID: mdl-9647443
ABSTRACT
RATIONALE AND OBJECTIVES:
The authors determine the feasibility of creating renal artery stenosis by overdilatation and deendothelialization and compare the model in normocholesterolemic versus hypercholesterolemic rabbits.METHODS:
Thirty male New Zealand White rabbits were randomized into two groups group A (n = 15) was fed a normal diet and group B (n = 15) was fed a cholesterol-rich diet 4 weeks before stenosis induction. An aortogram was performed, then the right renal artery was overdilated with an angioplasty balloon-catheter, and deendothelialized. After 6 weeks, groups A and B were compared by angiographic and pathologic study.RESULTS:
Comparison of group A versus group B showed that 12 arteries (80%) versus 6 (40%) were angiographically stenotic (P < 0.05); 14 (93%) versus 12 (80%) contained neointima (NS), 12 (80%) versus 3 (20%) showed medial disorganization (P < 0.01), and 9 (60%) versus 2 (13%) presented adventitial fibrosis (P < 0.01).CONCLUSIONS:
A new model of endovascularly induced renal artery stenosis has been developed in rabbits. Medial proliferation and adventitial fibrosis are more frequent in normocholesterolemic rabbits.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Artéria Renal
/
Obstrução da Artéria Renal
/
Endotélio Vascular
/
Angioplastia com Balão
Limite:
Animals
Idioma:
En
Revista:
Invest Radiol
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
França