Effects of nicotine on methadone self-administration in humans.
Drug Alcohol Depend
; 50(2): 157-65, 1998 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-9649967
ABSTRACT
The effects of nicotine abstinence, ad libitum smoking, and 0, 2, and 4 mg nicotine gum on methadone self-administration were investigated. Five methadone-maintained patients with a history of smoking (18-30 cigarettes/day) were recruited as subjects. Upon arrival expired carbon monoxide levels were measured to confirm self-reported abstinence of 10-12 h. At 30 min prior to the methadone self-administration session, two response options were concurrently available. When a 64-button press requirement (FR64) was completed, 10 ml of 0.054 mg/ml methadone solution, or vehicle, was delivered. Immediately following, and 30, 60, 90, and 120 min after the self-administration session, expired carbon monoxide levels and typical symptoms of nicotine withdrawal were assessed. Relative to abstinence, subjects consumed more methadone following the 4-mg nicotine gum and ad libitum smoking conditions. Ratings of cigarette craving were significantly less following ad libitum smoking or administration of 4-mg nicotine gum, than following abstinence. Implications for understanding opioid and nicotine interactions are discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tabagismo
/
Comportamento Aditivo
/
Agonistas Nicotínicos
/
Dependência de Heroína
/
Metadona
/
Entorpecentes
/
Nicotina
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Drug Alcohol Depend
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Estados Unidos