Serum 25-hydroxyvitamin D levels and bone mineral density in 16-20 years-old girls: lack of association.
J Intern Med
; 243(5): 381-8, 1998 May.
Article
em En
| MEDLINE
| ID: mdl-9651561
ABSTRACT
OBJECTIVE:
Hypovitaminosis D has been shown to be associated with low bone mineral density in middle-aged and elderly women. The aim of this study was to evaluate whether such an association might exist in adolescent and young adult girls, approaching peak bone mass.DESIGN:
Cross-sectional study carried out in late winter.SETTING:
Reykjavik area at latitude 64 degrees N.SUBJECTS:
Two-hundred and fifty-nine Icelandic Caucasian girls, aged 16, 18 and 20 years, randomly selected from the registry of Reykjavik. MAIN OUTCOMEMEASURES:
Bone mineral density in lumbar spine, hip, distal forearm and total skeleton was measured with dual-energy X-ray absorptiometry (DEXA) and compared with 25-hydroxyvitamin D levels [25 (OH)D] in serum, measured by radioimmunoassay. Calcium and vitamin-D intake were also assessed by a questionnaire.RESULTS:
18.5% of the girls were below 25 nmol L-1 in serum 25 (OH)D which has been recognized as the lower normal limit for adults. No significant association was found between 25 (OH)D levels and bone mineral density.CONCLUSIONS:
Normal calcium and phosphate concentrations in plasma and normal bone mineral density are maintained in adolescent and young adult girls at lower 25 (OH)D levels than published 'normal' levels for middle-aged and elderly.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vitamina D
/
Densidade Óssea
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Female
/
Humans
Idioma:
En
Revista:
J Intern Med
Assunto da revista:
MEDICINA INTERNA
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Islândia