Protein kinase C: a potential pathway of macrophage activation with cisplatin.
Immunol Lett
; 61(2-3): 179-86, 1998 Apr.
Article
em En
| MEDLINE
| ID: mdl-9657272
ABSTRACT
Cisplatin (CP) has been reported to activate murine macrophages to tumoricidal state, however, its mechanism of action is not known. In the present study it is reported that the production of (a) interleukin-1 (IL-1); (b) tumor necrosis factor (TNF); (c) nitric oxide (NO); and (d) macrophage-mediated cytotoxicity by cisplatin-treated bone marrow-derived macrophages were inhibited by PKC inhibitors H-7 and chelerythrine chloride. Also, it was observed that treatment of macrophages with CP resulted in the translocation of PKC from the cytosol to the membrane fraction. These findings suggest the involvement of PKC in the activation of bone marrow-derived macrophages with cisplatin.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteína Quinase C
/
Cisplatino
/
Macrófagos
Limite:
Animals
Idioma:
En
Revista:
Immunol Lett
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Índia