Natural immunity and bone and muscle remodelling hormones in the elderly.
Mech Ageing Dev
; 102(2-3): 279-92, 1998 May 15.
Article
em En
| MEDLINE
| ID: mdl-9720658
ABSTRACT
Increasing evidence has demonstrated that the immune system is closely integrated with two other physiological systems endocrine and nervous. They communicate through circulating humoral factors such as cytokines, hormones and neurotransmitters. We undertook a cross-sectional analysis in a group of elderly subjects over 90 years to demonstrate that a functional relationship exists among the number and cytolytic activities of NK cells, bone and muscle remodelling hormones, anthropometric parameters and physical ability. Peripheral blood samples collected from 62, 90-106 years-old subjects underwent biochemical (bone and muscle remodelling hormone levels) and immunological determinations (Natural Killer cell distribution and activity), anthropometric and functional assessment. Significant associations were found among NK cell number and cytolytic activity and serum concentrations of vitamin D, anthropometric parameters, while functional independence in daily activity was only associated with NK cell number. In general a high level of physical ability was correlated with preserved body stores and vitamin D levels. In conclusion, our results stress the importance of nutritional evaluation in the clinical assessment of elderly people. The magnitude of the NK immune response, which constitutes the first line of defence against infected and neoplastic cells, is best preserved in oldest-old people with the best hormonal parameters and nutritional measures.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hormônio Paratireóideo
/
Envelhecimento
/
Fator de Crescimento Insulin-Like I
/
Células Matadoras Naturais
/
Remodelação Óssea
/
Hormônio do Crescimento Humano
/
Imunidade Inata
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Mech Ageing Dev
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Itália