Cytokine gene expression in cells derived from CSF of multiple sclerosis patients.
J Neuroimmunol
; 89(1-2): 198-205, 1998 Aug 14.
Article
em En
| MEDLINE
| ID: mdl-9726843
ABSTRACT
Cytokines are produced by numerous cell types in the peripheral blood and central nervous system (CNS), and have been implicated in the immunopathogenesis of multiple sclerosis (MS). We examined the relationship between cytokine gene expression of cerebrospinal fluid (CSF) derived cells from MS patients and disease activity as measured by contrast enhanced MRI. There was a significant correlation between the number of CSF cells and the number of contrast enhancing MRI lesions. Cytokine gene expression of TNF-alpha, IFN-gamma, and IL-10 was routinely seen, but IL-4 expression was absent except in two clinically quiescent patients. Trends were observed toward decreased TNF-alpha expression, but increased IL-10 expression, after treatment with IFN-beta1b.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Expressão Gênica
/
Citocinas
/
Leucócitos
/
Esclerose Múltipla
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Neuroimmunol
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Estados Unidos