Quinolinic acid and sigma receptor ligand: effect on pyramidal neurons of the CA1 sector of dorsal hippocampus following peripheral administration in rats.
Folia Neuropathol
; 36(2): 94-100, 1998.
Article
em En
| MEDLINE
| ID: mdl-9757620
ABSTRACT
Male Wistar rats, weighing 200-220 g, were used in the study. Quinolinic acid and racemic pentazocine were administered alone or together. Quinolinic acid was administered intraperitoneally (i.p.) in a dose of 60 mmol, racemic pentazocine intramuscularly in a dose of 2 mg/kg, once every 24 h for 8 days. The control group received 1 ml of saline i.p. once daily for 8 days. Pentazocine alone produced no signs of alteration in the hippocampal formation. Quinolinic acid produced neurotoxic effect in the CA1 area of the hippocampal formation. The presence of the dark-degenerated pyramidal cells was a common sign of a delayed excitotoxic effect. Pentazocine added to quinolinic acid markedly attenuated the neurotoxic effect of quinolinic acid. In such cases, only single dark degenerated cells were seen.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pentazocina
/
Canais de Cálcio
/
Receptores sigma
/
Ácido Quinolínico
/
Células Piramidais
/
Hipocampo
/
Analgésicos Opioides
Limite:
Animals
Idioma:
En
Revista:
Folia Neuropathol
Assunto da revista:
NEUROLOGIA
/
PATOLOGIA
Ano de publicação:
1998
Tipo de documento:
Article