[Pharmacological therapy of erectile dysfunction]. / Pharmakologische Therapie der erektilen Dysfunktion.
Urologe A
; 37(5): 503-8, 1998 Sep.
Article
em De
| MEDLINE
| ID: mdl-9796031
ABSTRACT
Pharmacotherapy of erectile dysfunction comprises oral and local application of drugs. Today, Yohimbin is the only drug listed for this indication. Yohimbin acts via central alpha-receptor blockade and showed a significant effect in a recent double blind study compared to placebo. The centrally acting substances Apomorphin and Trazodone were also tested for their potential use with Apomorphin showing promising results. The orally active phosphodiesterase-V inhibitor Sildenafil acts predominantly on the peripheral side; broad clinical studies demonstrated a significant effect of the drugs compared to placebo. For local use, intraurethral (MUSE) and intracavernous applications are available with PGE1 being the drug the most widely used for the moment. Since many different drugs with various modes of action and different modes of application are being developed at the moment, future pharmacological treatments will allow a more refined approach towards an individually adapted regimen.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Impotência Vasculogênica
/
Disfunção Erétil
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
Limite:
Humans
/
Male
Idioma:
De
Revista:
Urologe A
Ano de publicação:
1998
Tipo de documento:
Article