IGF-I levels in prepubertal and pubertal children with Down syndrome.
Minerva Endocrinol
; 23(2): 31-6, 1998 Jun.
Article
em En
| MEDLINE
| ID: mdl-9844353
ABSTRACT
BACKGROUND:
Growth retardation is a main feature of Down syndrome but it is still unclear whether an alteration of the GH/IGF-I axis is present in this condition. Concerning IGF-I levels, they have been found reduced by some authors but normal by others.METHODS:
On these bases, IGF-I levels have been assessed from prepubertal to late pubertal stages of gonadal maturation in a large group of children and adolescents with Down syndrome (DS, 68 M, 45 F, 12.5 +/- 0.6 yr; prepubertal n = 39, pubertal n = 74) with those in a group of normal children and adolescents (NS, 75 M, 87 F; 11.1 +/- 0.4 yr; prepubertal n = 94, pubertal n = 68).RESULTS:
Within each group, IGF-I levels were gender-independent while showed age-related variations with positive association with pubertal stage--peaking up in pubertal stage IV--(DS r = 0.6, NS r = 0.4, both p < 0.0001) and testosterone (DS r = 0.6, NS r = 0.5, p < 0.001) or estradiol (DS r = 0.6, NS r = 0.5, p < 0.001) levels. Considering whole groups, mean IGF-I levels in DS were slightly but significantly lower than those in NS (257.9 +/- 12.5 vs 310.8 +/- 12.6 micrograms/l, p < 0.02). Analyzing individual IGF-I levels in DS with respect to normal ranges per pubertal stage, more than 85% of IGF-I levels resulted within the normal limits. These results demonstrate that IGF-I levels in DS patients are generally within the normal range--though a slight reduction of mean IGF-I levels is present--and follow normal age-related variations with clear cut increase at puberty and positive association with gonadal steroid levels.CONCLUSIONS:
This evidence points toward the need to clarify the GH/IGF-I axis function and activity in DS patients.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fator de Crescimento Insulin-Like I
/
Puberdade
/
Síndrome de Down
Limite:
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Minerva Endocrinol
Ano de publicação:
1998
Tipo de documento:
Article