Successful treatment of refractory type 1 autoimmune hepatitis with methotrexate.
J Hepatol
; 29(6): 990-3, 1998 Dec.
Article
em En
| MEDLINE
| ID: mdl-9875647
ABSTRACT
BACKGROUND/AIMS:
Autoimmune hepatitis is a heterogeneous disorder that typically responds to glucocorticoids with or without azathioprine. Treatment options for patients not responding to standard therapy are limited.METHODS:
We describe a 52-year-old female who presented with jaundice, marked elevation in liver enzymes, positive antinuclear antibody and a liver biopsy consistent with autoimmune hepatitis. Liver enzymes did not normalize with prednisone alone. When azathioprine was added, the disease flared. The patient refused cyclosporine. Methotrexate 7.5 mg po per week resulted in normalization of liver enzymes, improved liver histology, and has maintained remission with a steroid-sparing effect. RESULTS/CONCLUSION:
In this patient methotrexate was used successfully to treat type 1 autoimmune hepatitis. This suggests that methotrexate may have a role in treatment of autoimmune hepatitis refractory to standard therapy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Metotrexato
/
Hepatite Autoimune
/
Imunossupressores
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
J Hepatol
Assunto da revista:
GASTROENTEROLOGIA
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Canadá