Stimulation by cigarette smoke of glutathione peroxidase system enzyme activities in rat lung.
Arch Environ Health
; 31(6): 286-90, 1976.
Article
em En
| MEDLINE
| ID: mdl-999340
ABSTRACT
This study was undertaken to evaluate the effect of in vivo cigarette smoke exposure on glutathione peroxidase--related enzyme systems of the rat lung. These enzymes, acting in concert, are thought to be responsible for disposing of toxic lipid peroxides in pulmonary tissue. Thirty-day-old rats were exposed to thirteen cigarettes per day for 21 days with a Walton reverse-smoking exposure apparatus. After 21 days of smoke exposure, the activities of glutathione peroxidase, glutathione reductase, and glucose-6-phosphate dehydrogenase were increased 34%, 24%, and 38%, respectively, over control values. This level of cigarette smoke exposure did not cause detectable histological lesions. We present the hypothesis that short-term, low-level cigarette smoke exposure is capable of initiating metabolic alterations in lung cells at exposures at which histological changes are not detectable by light microscopy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peroxidases
/
Fumar
/
Glutationa Peroxidase
/
Pulmão
Limite:
Animals
Idioma:
En
Revista:
Arch Environ Health
Ano de publicação:
1976
Tipo de documento:
Article