RESUMEN
Oral erosions and ulcers of pemphigus vulgaris (PV) are a debilitating condition that is usually difficult to treat. The wound healing properties of platelet-rich plasma (PRP) encouraged us to evaluate its usefulness in treatment of non-healing oral PV lesions. Seven patients with chronic oral PV, resistant to conventional therapy, were treated with weekly to monthly injections of PRP of affected mucosal membranes. All recruits reported improvement in pain and mastication and 6 of 7 patients had an improvement in pemphigus disease area index scores with PRP treatment. PRP injections seems to accelerate the healing process and decrease the pain and eating discomfort associated with the oral erosions and ulcers induced by PV.
Asunto(s)
Enfermedad Crónica/terapia , Enfermedades de la Boca/terapia , Pénfigo/terapia , Plasma Rico en Plaquetas , Cicatrización de Heridas , Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Enfermedades de la Boca/fisiopatología , Satisfacción del Paciente , Pénfigo/fisiopatología , Proyectos Piloto , Resultado del TratamientoAsunto(s)
Micosis Fungoide , Proteínas de Neoplasias/metabolismo , Fototerapia , Psoriasis , Receptor PAR-2/metabolismo , Neoplasias Cutáneas , Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Micosis Fungoide/metabolismo , Micosis Fungoide/patología , Micosis Fungoide/terapia , Psoriasis/metabolismo , Psoriasis/patología , Psoriasis/terapia , Neoplasias Cutáneas/metabolismo , Neoplasias Cutáneas/patología , Neoplasias Cutáneas/terapiaRESUMEN
BACKGROUND: Multiple therapeutic approaches are usually required when treating atrophic acne scars. Subcision was reported to be of value in improving rolling scars. Autologous platelet-rich plasma (PRP) has recently been proposed as an adjuvant treatment option for atrophic acne scars with few reports evaluating its efficacy. OBJECTIVE: Our objective was to compare the effect of intradermal injection of PRP vs combined PRP and subcision in the treatment of atrophic acne scars. METHODS: Thirty patients with bilateral atrophic acne scars were enrolled. Each patient received three monthly sessions. Each side of the face was randomly treated either with intradermal PRP alone or with combined treatment with subcision followed by PRP injection. Patients were assessed at 3 and 6 months following the last treatment session. Evaluation of serial photographs was performed by two blinded investigators. RESULTS: Platelet-rich plasma alone showed a better response, fewer side effects, and shorter downtime compared to combined subcision and PRP. CONCLUSION: Autologous PRP injection can be a therapeutic option in the treatment of atrophic acne scars, with fewer complications and better tolerability than combined subcision and autologous PRP.