Detalles de la búsqueda
1.
Design, synthesis, and biological evaluation of novel benzimidazole derivatives as sphingosine kinase 1 inhibitor.
Arch Pharm (Weinheim);
354(9): e2100080, 2021 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-34128259
2.
New thiopyrimidine-benzenesulfonamide conjugates as selective carbonic anhydrase II inhibitors: synthesis, in vitro biological evaluation, and molecular docking studies.
Bioorg Med Chem;
28(5): 115329, 2020 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32007388
3.
Potent Dual Inhibitors of Steroid Sulfatase and 17ß-Hydroxysteroid Dehydrogenase Type 1 with a Suitable Pharmacokinetic Profile for In Vivo Proof-of-Principle Studies in an Endometriosis Mouse Model.
J Med Chem;
66(13): 8975-8992, 2023 07 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-37369108
4.
Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof-of-Principle.
Adv Sci (Weinh);
10(5): e2204443, 2023 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-36596691
5.
Inhibitors of the Elastase LasB for the Treatment of Pseudomonas aeruginosa Lung Infections.
ACS Cent Sci;
9(12): 2205-2215, 2023 Dec 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-38161367
6.
Dual Targeting of Steroid Sulfatase and 17ß-Hydroxysteroid Dehydrogenase Type 1 by a Novel Drug-Prodrug Approach: A Potential Therapeutic Option for the Treatment of Endometriosis.
J Med Chem;
65(17): 11726-11744, 2022 09 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-35993890
7.
Discovery and Characterization of Synthesized and FDA-Approved Inhibitors of Clostridial and Bacillary Collagenases.
J Med Chem;
65(19): 12933-12955, 2022 10 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-36154055
8.
Divergent synthesis and biological evaluation of 2-(trifluoromethyl)pyridines as virulence-attenuating inverse agonists targeting PqsR.
Eur J Med Chem;
226: 113797, 2021 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34520957
9.
17ß-Hydroxysteroid Dehydrogenase Type 1 Inhibition: A Potential Treatment Option for Non-Small Cell Lung Cancer.
ACS Med Chem Lett;
12(12): 1920-1924, 2021 Dec 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34917255
10.
Inhibitors of 17ß-hydroxysteroid dehydrogenase type 1, 2 and 14: Structures, biological activities and future challenges.
Mol Cell Endocrinol;
489: 66-81, 2019 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30336189
11.
Development of potential preclinical candidates with promising in vitro ADME profile for the inhibition of type 1 and type 2 17ß-Hydroxysteroid dehydrogenases: Design, synthesis, and biological evaluation.
Eur J Med Chem;
178: 93-107, 2019 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31176098
12.
Effects of 17ß-HSD2 inhibition in bones on osteoporosis based on an animal rat model.
J Steroid Biochem Mol Biol;
192: 105405, 2019 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-31185280
13.
Design, Synthesis, and Biological Characterization of Orally Active 17ß-Hydroxysteroid Dehydrogenase Type 2 Inhibitors Targeting the Prevention of Osteoporosis.
J Med Chem;
62(15): 7289-7301, 2019 08 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-31343176
14.
Targeted Endocrine Therapy: Design, Synthesis, and Proof-of-Principle of 17ß-Hydroxysteroid Dehydrogenase Type 2 Inhibitors in Bone Fracture Healing.
J Med Chem;
62(3): 1362-1372, 2019 02 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-30645111
15.
Highly Potent 17ß-HSD2 Inhibitors with a Promising Pharmacokinetic Profile for Targeted Osteoporosis Therapy.
J Med Chem;
61(23): 10724-10738, 2018 12 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-30480443
16.
First Dual Inhibitors of Steroid Sulfatase (STS) and 17ß-Hydroxysteroid Dehydrogenase Type 1 (17ß-HSD1): Designed Multiple Ligands as Novel Potential Therapeutics for Estrogen-Dependent Diseases.
J Med Chem;
60(9): 4086-4092, 2017 05 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-28406629
17.
Treatment of estrogen-dependent diseases: Design, synthesis and profiling of a selective 17ß-HSD1 inhibitor with sub-nanomolar IC50 for a proof-of-principle study.
Eur J Med Chem;
127: 944-957, 2017 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27852458
18.
Part I: Design, synthesis and biological evaluation of novel pyrazole-benzimidazole conjugates as checkpoint kinase 2 (Chk2) inhibitors with studying their activities alone and in combination with genotoxic drugs.
Eur J Med Chem;
134: 392-405, 2017 Jul 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-28433679
19.
First Structure-Activity Relationship of 17ß-Hydroxysteroid Dehydrogenase Type 14 Nonsteroidal Inhibitors and Crystal Structures in Complex with the Enzyme.
J Med Chem;
59(23): 10719-10737, 2016 12 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27933965
20.
Towards the evaluation in an animal disease model: Fluorinated 17ß-HSD1 inhibitors showing strong activity towards both the human and the rat enzyme.
Eur J Med Chem;
103: 56-68, 2015 Oct 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-26322835