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1.

Neoantigen-targeted CD8⁺ T cell responses with PD-1 blockade therapy.

Puig-Saus, Cristina; Sennino, Barbara; Peng, Songming; Wang, Clifford L; Pan, Zheng; Yuen, Benjamin; Purandare, Bhamini; An, Duo; Quach, Boi B; Nguyen, Diana; Xia, Huiming; Jilani, Sameeha; Shao, Kevin; McHugh, Claire; Greer, John; Peabody, Phillip; Nayak, Saparya; Hoover, Jonathan; Said, Sara; Jacoby, Kyle; Dalmas, Olivier; Foy, Susan P; Conroy, Andrew; Yi, Michael C; Shieh, Christine; Lu, William; Heeringa, Katharine; Ma, Yan; Chizari, Shahab; Pilling, Melissa J; Ting, Marc; Tunuguntla, Ramya; Sandoval, Salemiz; Moot, Robert; Hunter, Theresa; Zhao, Sidi; Saco, Justin D; Perez-Garcilazo, Ivan; Medina, Egmidio; Vega-Crespo, Agustin; Baselga-Carretero, Ignacio; Abril-Rodriguez, Gabriel; Cherry, Grace; Wong, Deborah J; Hundal, Jasreet; Chmielowski, Bartosz; Speiser, Daniel E; Bethune, Michael T; Bao, Xiaoyan R; Gros, Alena.

Nature; 615(7953): 697-704, 2023 03.

Artículo en Inglés | MEDLINE | ID: mdl-36890230

2.

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma.

Zaretsky, Jesse M; Garcia-Diaz, Angel; Shin, Daniel S; Escuin-Ordinas, Helena; Hugo, Willy; Hu-Lieskovan, Siwen; Torrejon, Davis Y; Abril-Rodriguez, Gabriel; Sandoval, Salemiz; Barthly, Lucas; Saco, Justin; Homet Moreno, Blanca; Mezzadra, Riccardo; Chmielowski, Bartosz; Ruchalski, Kathleen; Shintaku, I Peter; Sanchez, Phillip J; Puig-Saus, Cristina; Cherry, Grace; Seja, Elizabeth; Kong, Xiangju; Pang, Jia; Berent-Maoz, Beata; Comin-Anduix, Begoña; Graeber, Thomas G; Tumeh, Paul C; Schumacher, Ton N M; Lo, Roger S; Ribas, Antoni.

N Engl J Med; 375(9): 819-29, 2016 Sep 01.

Artículo en Inglés | MEDLINE | ID: mdl-27433843

3.

CAR-T cell therapy targeting surface expression of TYRP1 to treat cutaneous and rare melanoma subtypes.

Jilani, Sameeha; Saco, Justin D; Mugarza, Edurne; Pujol-Morcillo, Aleida; Chokry, Jeffrey; Ng, Clement; Abril-Rodriguez, Gabriel; Berger-Manerio, David; Pant, Ami; Hu, Jane; Gupta, Rubi; Vega-Crespo, Agustin; Baselga-Carretero, Ignacio; Chen, Jia M; Shin, Daniel Sanghoon; Scumpia, Philip; Radu, Roxana A; Chen, Yvonne; Ribas, Antoni; Puig-Saus, Cristina.

Nat Commun; 15(1): 1244, 2024 Feb 09.

Artículo en Inglés | MEDLINE | ID: mdl-38336975

4.

Antitumor Immune Responses in B2M-Deficient Cancers.

Torrejon, Davis Y; Galvez, Mildred; Abril-Rodriguez, Gabriel; Campbell, Katie M; Medina, Egmidio; Vega-Crespo, Agustin; Kalbasi, Anusha; Comin-Anduix, Begoña; Ribas, Antoni.

Cancer Immunol Res; 11(12): 1642-1655, 2023 12 01.

Artículo en Inglés | MEDLINE | ID: mdl-37801341

5.

Multimodal single-cell and whole-genome sequencing of small, frozen clinical specimens.

Wang, Yiping; Fan, Joy Linyue; Melms, Johannes C; Amin, Amit Dipak; Georgis, Yohanna; Barrera, Irving; Ho, Patricia; Tagore, Somnath; Abril-Rodríguez, Gabriel; He, Siyu; Jin, Yinuo; Biermann, Jana; Hofree, Matan; Caprio, Lindsay; Berhe, Simon; Khan, Shaheer A; Henick, Brian S; Ribas, Antoni; Macosko, Evan Z; Chen, Fei; Taylor, Alison M; Schwartz, Gary K; Carvajal, Richard D; Azizi, Elham; Izar, Benjamin.

Nat Genet; 55(1): 19-25, 2023 01.

Artículo en Inglés | MEDLINE | ID: mdl-36624340

6.

Remodeling of the tumor microenvironment through PAK4 inhibition sensitizes tumors to immune checkpoint blockade.

Abril-Rodríguez, Gabriel; Torrejon, Davis Y; Karin, Daniel; Campbell, Katie M; Medina, Egmidio; Saco, Justin D; Galvez, Mildred; Champhekar, Ameya S; Perez-Garcilazo, Ivan; Baselga-Carretero, Ignacio; Singh, Jas; Comin-Anduix, Begoña; Puig-Saus, Cristina; Ribas, Antoni.

Cancer Res Commun; 2(10): 1214-1228, 2022 10.

Artículo en Inglés | MEDLINE | ID: mdl-36588582

7.

Purine nucleoside phosphorylase enables dual metabolic checkpoints that prevent T cell immunodeficiency and TLR7-associated autoimmunity.

Abt, Evan R; Rashid, Khalid; Le, Thuc M; Li, Suwen; Lee, Hailey R; Lok, Vincent; Li, Luyi; Creech, Amanda L; Labora, Amanda N; Mandl, Hanna K; Lam, Alex K; Cho, Arthur; Rezek, Valerie; Wu, Nanping; Abril-Rodriguez, Gabriel; Rosser, Ethan W; Mittelman, Steven D; Hugo, Willy; Mehrling, Thomas; Bantia, Shanta; Ribas, Antoni; Donahue, Timothy R; Crooks, Gay M; Wu, Ting-Ting; Radu, Caius G.

J Clin Invest; 132(16)2022 08 15.

Artículo en Inglés | MEDLINE | ID: mdl-35653193

8.

Melanoma dedifferentiation induced by IFN-Î³ epigenetic remodeling in response to anti-PD-1 therapy.

Kim, Yeon Joo; Sheu, Katherine M; Tsoi, Jennifer; Abril-Rodriguez, Gabriel; Medina, Egmidio; Grasso, Catherine S; Torrejon, Davis Y; Champhekar, Ameya S; Litchfield, Kevin; Swanton, Charles; Speiser, Daniel E; Scumpia, Philip O; Hoffmann, Alexander; Graeber, Thomas G; Puig-Saus, Cristina; Ribas, Antoni.

J Clin Invest; 131(12)2021 06 15.

Artículo en Inglés | MEDLINE | ID: mdl-33914706

9.

IL-32Î³ potentiates tumor immunity in melanoma.

Gruber, Thomas; Kremenovic, Mirela; Sadozai, Hassan; Rombini, Nives; Baeriswyl, Lukas; Maibach, Fabienne; Modlin, Robert L; Gilliet, Michel; von Werdt, Diego; Hunger, Robert E; Seyed Jafari, S Morteza; Parisi, Giulia; Abril-Rodriguez, Gabriel; Ribas, Antoni; Schenk, Mirjam.

JCI Insight; 5(18)2020 09 17.

Artículo en Inglés | MEDLINE | ID: mdl-32841222

10.

PAK4 inhibition improves PD-1 blockade immunotherapy.

Abril-Rodriguez, Gabriel; Torrejon, Davis Y; Liu, Wei; Zaretsky, Jesse M; Nowicki, Theodore S; Tsoi, Jennifer; Puig-Saus, Cristina; Baselga-Carretero, Ignacio; Medina, Egmidio; Quist, Michael J; Garcia, Alejandro J; Senapedis, William; Baloglu, Erkan; Kalbasi, Anusha; Cheung-Lau, Gardenia; Berent-Maoz, Beata; Comin-Anduix, Begoña; Hu-Lieskovan, Siwen; Wang, Cun-Yu; Grasso, Catherine S; Ribas, Antoni.

Nat Cancer; 1(1): 46-58, 2020.

Artículo en Inglés | MEDLINE | ID: mdl-34368780

11.

Overcoming Genetically Based Resistance Mechanisms to PD-1 Blockade.

Torrejon, Davis Y; Abril-Rodriguez, Gabriel; Champhekar, Ameya S; Tsoi, Jennifer; Campbell, Katie M; Kalbasi, Anusha; Parisi, Giulia; Zaretsky, Jesse M; Garcia-Diaz, Angel; Puig-Saus, Cristina; Cheung-Lau, Gardenia; Wohlwender, Thomas; Krystofinski, Paige; Vega-Crespo, Agustin; Lee, Christopher M; Mascaro, Pau; Grasso, Catherine S; Berent-Maoz, Beata; Comin-Anduix, Begoña; Hu-Lieskovan, Siwen; Ribas, Antoni.

Cancer Discov; 10(8): 1140-1157, 2020 08.

Artículo en Inglés | MEDLINE | ID: mdl-32467343

12.

Conserved Interferon-Î³ Signaling Drives Clinical Response to Immune Checkpoint Blockade Therapy in Melanoma.

Grasso, Catherine S; Tsoi, Jennifer; Onyshchenko, Mykola; Abril-Rodriguez, Gabriel; Ross-Macdonald, Petra; Wind-Rotolo, Megan; Champhekar, Ameya; Medina, Egmidio; Torrejon, Davis Y; Shin, Daniel Sanghoon; Tran, Phuong; Kim, Yeon Joo; Puig-Saus, Cristina; Campbell, Katie; Vega-Crespo, Agustin; Quist, Michael; Martignier, Christophe; Luke, Jason J; Wolchok, Jedd D; Johnson, Douglas B; Chmielowski, Bartosz; Hodi, F Stephen; Bhatia, Shailender; Sharfman, William; Urba, Walter J; Slingluff, Craig L; Diab, Adi; Haanen, John B A G; Algarra, Salvador Martin; Pardoll, Drew M; Anagnostou, Valsamo; Topalian, Suzanne L; Velculescu, Victor E; Speiser, Daniel E; Kalbasi, Anusha; Ribas, Antoni.

Cancer Cell; 38(4): 500-515.e3, 2020 10 12.

Artículo en Inglés | MEDLINE | ID: mdl-32916126

13.

Genetic Mechanisms of Immune Evasion in Colorectal Cancer.

Grasso, Catherine S; Giannakis, Marios; Wells, Daniel K; Hamada, Tsuyoshi; Mu, Xinmeng Jasmine; Quist, Michael; Nowak, Jonathan A; Nishihara, Reiko; Qian, Zhi Rong; Inamura, Kentaro; Morikawa, Teppei; Nosho, Katsuhiko; Abril-Rodriguez, Gabriel; Connolly, Charles; Escuin-Ordinas, Helena; Geybels, Milan S; Grady, William M; Hsu, Li; Hu-Lieskovan, Siwen; Huyghe, Jeroen R; Kim, Yeon Joo; Krystofinski, Paige; Leiserson, Mark D M; Montoya, Dennis J; Nadel, Brian B; Pellegrini, Matteo; Pritchard, Colin C; Puig-Saus, Cristina; Quist, Elleanor H; Raphael, Ben J; Salipante, Stephen J; Shin, Daniel Sanghoon; Shinbrot, Eve; Shirts, Brian; Shukla, Sachet; Stanford, Janet L; Sun, Wei; Tsoi, Jennifer; Upfill-Brown, Alexander; Wheeler, David A; Wu, Catherine J; Yu, Ming; Zaidi, Syed H; Zaretsky, Jesse M; Gabriel, Stacey B; Lander, Eric S; Garraway, Levi A; Hudson, Thomas J; Fuchs, Charles S; Ribas, Antoni.

Cancer Discov; 8(6): 730-749, 2018 06.

Artículo en Inglés | MEDLINE | ID: mdl-29510987

14.

SnapShot: Immune Checkpoint Inhibitors.

Abril-Rodriguez, Gabriel; Ribas, Antoni.

Cancer Cell; 31(6): 848-848.e1, 2017 06 12.

Artículo en Inglés | MEDLINE | ID: mdl-28609660

15.

Conserved Interferon-Î³ Signaling Drives Clinical Response to Immune Checkpoint Blockade Therapy in Melanoma.

Grasso, Catherine S; Tsoi, Jennifer; Onyshchenko, Mykola; Abril-Rodriguez, Gabriel; Ross-Macdonald, Petra; Wind-Rotolo, Megan; Champhekar, Ameya; Medina, Egmidio; Torrejon, Davis Y; Shin, Daniel Sanghoon; Tran, Phuong; Kim, Yeon Joo; Puig-Saus, Cristina; Campbell, Katie; Vega-Crespo, Agustin; Quist, Michael; Martignier, Christophe; Luke, Jason J; Wolchok, Jedd D; Johnson, Douglas B; Chmielowski, Bartosz; Hodi, F Stephen; Bhatia, Shailender; Sharfman, William; Urba, Walter J; Slingluff, Craig L; Diab, Adi; Haanen, John B A G; Algarra, Salvador Martin; Pardoll, Drew M; Anagnostou, Valsamo; Topalian, Suzanne L; Velculescu, Victor E; Speiser, Daniel E; Kalbasi, Anusha; Ribas, Antoni.

Cancer Cell; 39(1): 122, 2021 Jan 11.

Artículo en Inglés | MEDLINE | ID: mdl-33306984

16.

Publisher Correction: PAK4 inhibition improves PD-1 blockade immunotherapy.

Abril-Rodriguez, Gabriel; Torrejon, Davis Y; Liu, Wei; Zaretsky, Jesse M; Nowicki, Theodore S; Tsoi, Jennifer; Puig-Saus, Cristina; Baselga-Carretero, Ignacio; Medina, Egmidio; Quist, Michael J; Garcia, Alejandro J; Senapedis, William; Baloglu, Erkan; Kalbasi, Anusha; Cheung-Lau, Gardenia; Berent-Maoz, Beata; Comin-Anduix, Begoña; Hu-Lieskovan, Siwen; Wang, Cun-Yu; Grasso, Catherine S; Ribas, Antoni.

Nat Cancer; 1(2): 264, 2020 02.

Artículo en Inglés | MEDLINE | ID: mdl-35122015

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Neoantigen-targeted CD8⁺ T cell responses with PD-1 blockade therapy.

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma.

CAR-T cell therapy targeting surface expression of TYRP1 to treat cutaneous and rare melanoma subtypes.

Antitumor Immune Responses in B2M-Deficient Cancers.

Multimodal single-cell and whole-genome sequencing of small, frozen clinical specimens.

Remodeling of the tumor microenvironment through PAK4 inhibition sensitizes tumors to immune checkpoint blockade.

Purine nucleoside phosphorylase enables dual metabolic checkpoints that prevent T cell immunodeficiency and TLR7-associated autoimmunity.

Melanoma dedifferentiation induced by IFN-Î³ epigenetic remodeling in response to anti-PD-1 therapy.

IL-32Î³ potentiates tumor immunity in melanoma.

PAK4 inhibition improves PD-1 blockade immunotherapy.

Overcoming Genetically Based Resistance Mechanisms to PD-1 Blockade.

Conserved Interferon-Î³ Signaling Drives Clinical Response to Immune Checkpoint Blockade Therapy in Melanoma.

Genetic Mechanisms of Immune Evasion in Colorectal Cancer.

SnapShot: Immune Checkpoint Inhibitors.

Conserved Interferon-Î³ Signaling Drives Clinical Response to Immune Checkpoint Blockade Therapy in Melanoma.

Publisher Correction: PAK4 inhibition improves PD-1 blockade immunotherapy.