Phacomatosis melanovascularis: a new example of non-allelic twin spotting.

We report an infant who had a combination of two rather common nevoid skin conditions, namely "telangiectatic nevus" or "capillary malformation", and "hyperpigmented mosaicism" or "segmental pigmentary disorder" in close apposition, occupying large areas of the body in a mosaic distribution. This association may be considered a further example of didymosis, for which we propose the term, "phacomatosis melanovascularis" to denote a possible non-allelic twin spotting condition. To our knowledge, this is the first case reported in the literature.

Intralymphatic granulomas as a pathogenic factor in cheilitis granulomatosa/Melkersson-Rosenthal syndrome: report of a case with immunohistochemical and molecular studies.

Orofacial granulomatosis, an uncommon immunologically mediated disorder, includes cheilitis granulomatosa and Melkersson-Rosenthal syndrome. It is clinically characterized by recurrent or persistent swelling of the orofacial tissues with a spectrum of other orofacial features and sometimes with neurological symptoms. The pathological findings are varied but are often characterized by the presence of noncaseating granuloma. We present a new case of orofacial granulomatosis with unusual histopathological findings, namely, intralymphatic granulomas. These may be the cause of the tissue edema. We demonstrated, by immunohistochemical studies, the lymphatic nature of the vessels affected by the granulomatous process.

The quadrivalent human papillomavirus vaccine: erythema multiforme and cutaneous side effects after administration.

The quadrivalent human papillomavirus (qHPV) vaccine, the first vaccine for use in the prevention of cervical cancer and condyloma acuminatum, was approved in June 2006. In 2008, the mass media reported suspected links between the qHPV vaccine and serious adverse events; however, several studies have found that the vaccine is safe and the main adverse events are mild local reactions. Erythema multiforme (EM) is an acute self-limited cutaneous or mucocutaneous syndrome characterized by the abrupt onset of symmetric target lesions. The clinical manifestations and histological features of EM, Stevens-Johnson syndrome and toxic epidermal necrolysis show considerable overlap, and they are classically considered to represent a spectrum of skin disorders. We present a case of EM following qHPV vaccination to review the cutaneous side effects of this vaccine and the possibility of more serious side effects with the administration of booster doses.

A purpuric rash.

Kelly is 28 years of age and a recreational sea swimmer and surfer. He presented with a rash on both arms of 6 months duration. Kelly said a similar eruption occurred 12 months previously and resolved in a few weeks with 1% hydrocortisone cream. He has no significant past history, is not on any medication, and there is no recent history of trauma or contact with insects or animals. Physical examination revealed multiple, flat, nonblanching dark red lesions on the medial aspect of both arms (Figure 1, 2). The rest of the physical examination was unremarkable. Full blood examination revealed normal levels of haemoglobin, white cells and platelets, and coagulation studies are normal.