Inflammatory complications of vocal fold injection with hyaluronic acid: a multiinstitutional study

Background/aim: This study aimed to assess the inflammatory adverse reactions of vocal fold injection laryngoplasty with hyaluronic acid. Materials and methods: This study was a retrospective chart review of patients who underwent vocal fold injection augmentation with HA injection from January 2005 to September 2016 in nine different institutions. Demographic data, indication for injection, injection techniques, types of injection material, settings of procedure, and complications were reviewed. The types of complication, onset time, and management of complications were also noted. Results: In all, 467 patients were identified. The majority of patients had been injected under general anesthesia (n = 382, 84.7%). For injection material, two different types of hyaluronic acid were used: hyaluronic acid alone or hyaluronic acid with dextranomer. Complications occurred in nine patients (1.9%). The majority of complications were inflammatory reactions (n = 7, 1.47%). Main symptoms were dysphonia and/or dyspnea with an onset of 0 h to 3 weeks after the hyaluronic acid injection. Three patients were hospitalized, one of which was also intubated and observed in the intensive care unit for 24 h. Systemic steroids and antibiotics were the main medical treatment in the majority of cases. There was no statistical difference in complication rates between patients who received hyaluronic acid and those who received hyaluronic acid with dextranomer (P = 0.220). Conclusion: Hyaluronic acid can be considered as a safe substance for the injection of vocal folds with a low risk of inflammatory reaction.

Anatomical landmarks for cochlear implantation in ossified cochleas.

PURPOSE: In this study, we aimed to introduce the facial nerve as a new anatomical landmark which can be used in ossified cochleas during cochlear implantation. We also set out to define a safe line to preserve the internal auditory canal (IAC) while drilling the basal turn of the cochlea. METHODS: Thirty patients who had temporal computed tomography (CT) were studied. The distances from the facial nerve and the round window to the IAC, carotid artery, and jugular bulb were measured in the reformatted CT images. We have created a line in the direction of the stapedial tendon from the round window to the IAC and called it ROWIAC (Round window-IAC) line. We have investigated whether this line intersects the IAC and measured the distances from this line to the IAC. RESULTS: Fifty-four temporal CT scans were included to the study. The mean distances from the facial nerve to the IAC, carotid artery, and jugular bulb were 8.8 ± 0.9, 15.0 ± 2.0, and 12.2 ± 2.9 mm, respectively. The mean distances from the round window to these structures were 3.8 ± 0.7, 9.4 ± 2.2, and 8.3 ± 2.9 mm, respectively. ROWIAC line did not intersect the IAC in any of the patients. The mean distance between this line and the IAC was 0.8 ± 0.4 mm. CONCLUSION: We propose that facial nerve and ROWIAC line can be used as potential landmarks during cochlear implantation in ossified cochleas to protect the adjacent neurovascular structures.

Laryngeal Electromyography is Helpful for Cardiovocal Syndrome.

Laryngeal electromyography is used in the evaluation of vocal cord paralysis to confirm the diagnosis, to guide the diagnostic work-up for etiology, to provide prognostic information and to help choose the correct treatment for the patient. Cardiovocal syndrome is characterised by vocal cord paralysis due to a cardiovascular disease. A wide spectrum of conditions can result in this syndrome. Here we present a case of cardiovocal syndrome in association with primary pulmonary hypertension. Laryngeal electromyography was used to guide the work-up of differential diagnosis and also for further intervention with respect to vocal cord paralysis in this patient.

Videolaryngostroboscopy versus microlaryngoscopy for the diagnosis of benign vocal cord lesions: a prospective clinical study.

The aim of this study is to prospectively compare rigid videolaryngostroboscopy with microlaryngoscopy for the diagnosis of benign vocal cord lesions. Eighty-five adult patients with benign vocal cord lesions were evaluated with videolaryngostroboscopy and later underwent microlaryngoscopy. During microlaryngoscopy, systematic examination of the glottis was conducted, including careful inspection and meticulous palpation of the vocal cords from anterior commissure to arytenoids. Preoperative and intraoperative diagnoses were analyzed. One hundred and forty-one lesions were diagnosed preoperatively with rigid videolaryngostroboscopy in 85 patients. Microlaryngoscopy revealed a total of 199 lesions in these patients, demonstrating a 41.1 % higher diagnostic yield. Forty-five (77.6 %) of the 58 additional lesions involved structural abnormalities, including sulcus vocalis, microwebs, vascular ectasia, mucosal bridges, and anterior web. The preoperative diagnosis was consistent with the postoperative diagnosis in only 29 patients (34.2 %). For the rest of the patients (n = 56, 65.8 %), the preoperative diagnosis was either changed, or new lesions were identified during microlaryngoscopy. Intraoperative diagnosis of benign vocal cord lesions differs significantly from preoperative diagnosis, regarding both the type and number of lesions present. A large proportion of patients diagnosed with videolaryngostroboscopy have additional lesions, particularly structural abnormalities. Precise inspection and palpation of vocal cords are thus essential during microlaryngoscopy.

Vocal fold paresis accompanying vocal fold polyps.

The aim of this study was to evaluate patients with vocal fold polyps using laryngeal electromyography (LEMG) for the presence of vocal fold paresis and to compare transnasal fiberoptic and rigid stroboscopic findings between polyp patients with normal LEMG and with vocal fold paresis. Thirty-five patients with a vocal fold polyp underwent transnasal fiberoptic laryngoscopy, rigid laryngostroboscopy, and LEMG. The findings were compared between the LEMG-confirmed vocal fold paresis patients and the normal LEMG patients. LEMG resulted in a diagnosis of unilateral or bilateral vocal fold paresis in 17 of 35 patients (48.6 %). More men than women with vocal fold polyps had vocal fold paresis (p < 0.05). The vocal fold paresis group had higher presence of axial rotation and hypomobility of vocal folds, higher asymmetry of vertical height of vocal folds, and less presence of longitudinal stretch of vocal folds (p < 0.05). Medial-lateral compression of the false vocal folds and anterior-posterior approximation of the larynx did not show any difference between the groups. No significant difference was found in vibratory wave characteristics between the groups through rigid laryngostroboscopy. Vocal fold paresis was present in almost half of the patients with vocal fold polyps. Paresis can only be accurately diagnosed with LEMG. Transnasal fiberoptic laryngoscopic examination is helpful to recognize vocal fold paresis in vocal fold polyp patients, while stroboscopic examination is not useful to identify it in vocal fold polyp patients.

Maxillectomy for Cementifying Osseous Dysplasia of the Maxilla: A Case Report.

OBJECTIVES: Osseous dysplasias are the most common subtype of fibro-osseous lesions of the maxillofacial bones. They are benign and often present as incidental asymptomatic lesions. Diagnosis can be made with clinical and radiographic examination. CASE REPORT: This article reports the case of a 47-year-old man with a huge cementifying osseous dysplasia of the maxilla that presented with secondary infection after teeth extraction and repair of oroantral fistula. A subtotal maxillectomy had to be done after conservative treatment failed to resolve the infection. DISCUSSION/CONCLUSION: Biopsy, tooth extraction or surgical trauma to the affected bones of osseous dysplasia could easily lead to severe secondary infection, the treatment of which may be very difficult, and thus should be avoided if possible.

[Evaluation of benign vocal cord lesions with laryngeal electromyography]. / Benign vokal kord lezyonlarinin larengeal elektromiyografi ile degerlendirilmesi.

OBJECTIVES: This study aims to identify patients with benign vocal cord lesions using laryngeal electromyography (EMG) and to investigate the presence of accompanying vocal cord paresis. PATIENTS AND METHODS: Twenty-eight patients (18 males and 10 females; mean age 38.6±10.2 years; range 22 to 59 years) who were diagnosed with benign vocal cord lesion using a rigid laryngostroboscopy underwent laryngeal EMG and the presence of neurogenic involvement was investigated. RESULTS: Laryngostroboscopic examination revealed polyp in 85.7% (n=24), Reinke's edema in 10.7% (n=3), submucosal cyst in 10.7% (n=3), and contact granuloma in 3.6% (n=1). Of the patients, 14.2% (n=4) were suspected to have vocal cord paresis. Laryngeal EMG revealed neurogenic involvement in at least one of the larynx muscles in 57.2% (n=16) of the patients. Eight patients (28.6%) had unilateral neurogenic involvement, while three (10.7%) demonstrated isolated recurrent laryngeal nerve paresis two (7.2%) demonstrated isolated superior laryngeal nerve paresis, and three (10.7%) demonstrated combined recurrent and superior laryngeal nerve paresis. Six (21.4%) of eight patients with bilateral neurogenic involvement had paresis in three laryngeal nerves, whereas in two (7.2%) patients four laryngeal nerves were affected. CONCLUSION: Our study shows that vocal cord paresis frequently accompanies benign vocal cord lesions. Laryngeal EMG is useful to identify clinically suspected or unsuspected paresis with physical examination precisely.

Validation of the Acoustic Voice Quality Index Version 03.01 in Turkish.

OBJECTIVES: The aim of this study was to validate the Acoustic Voice Quality Index (AVQI) version 3.01 in the Turkish-speaking population. MATERIALS AND METHODS: Concatenated voice samples of the sustained vowel [a:] and continuous speech were collected from 127 dysphonic and 128 normophonic participants. The auditory-perceptual evaluation was performed by five experienced raters using the Grade parameter of the Grade, Roughness, Breathiness, Asthenia, Strain scale. Rater reliability, concurrent validity, diagnostic accuracy, and differences between normophonic and dysphonic groups were analyzed for the AVQI version 3.01. RESULTS: The number of syllables for the standardized reading text with the concatenation of the voiced parts lasting around 3 seconds (mean = 3.84 seconds) was 36. The intraclass correlation coefficient (ICC) values of intra-rater reliability of G scores of five raters were excellent (mean ICC = 0.934), and of inter-rater reliability, they varied between moderate and excellent (mean ICC = 0.786). AVQIv3 demonstrated a high diagnostic accuracy with area under receiver-operating characteristic curve = 0.906 in identifying disrupted versus normal voice quality. With sensitivity of 80% and specificity of 94%, AVQIv3 = 2.345 was the cutoff point that differentiated most accurately between normophonic and dysphonic voices in Turkish. CONCLUSION: AVQIv3 is an ecologically valid tool for objective differentiation between dysphonic and normal voices in the Turkish language.

Myopericytoma of the tongue: a case report.

Myopericytoma is a rare benign tumour composed of pericytic cells that show myoid differentiation and have a tendency for concentric perivascular growth. It belongs to a spectrum ofperivascular myoid cell neoplasms. To date, only a small number of cases of myopericytoma involving the oral cavity have been reported. We describe a case of myopericytoma presenting as a slowly growing tongue nodule in a 61-year-old woman. A diagnosis of myopericytoma was established with the histopathological findings combined with immunohistochemical staining. Myopericytoma should be included in the differential diagnosis of well-circumscribed, slow-growing lesions of the oral cavity.

[Can enough lymph nodes be taken out through lateral neck dissection in patients with larynx cancer?]. / Larenks kanserli hastalarda lateral boyun diseksiyonu ile yeterli sayida lenf nodu çikarilabiliyor mu?

OBJECTIVES: This study aims to evaluate whether the number of lymph nodes which are dissected by lateral neck dissection (LND) is enough and to compare the number of lymph nodes which are dissected from the same lymph node regions by radical and type 1 modified radical neck dissection (RND). PATIENTS AND METHODS: Between January 2000 and June 2004, data of 98 neck dissection materials which were performed to 63 patients (52 males, 11 females; mean age 61.9 years; range 48 to 75 years) with larynx cancer were retrospectively analyzed. The number of lymph nodes taken from the second, third and fourth regions of radical and type 1 modified RND and LND were individually and totally compared. The American Joint Committee on Cancer (AJCC) tumor node metastasis (TNM) classification system was used for primary tumor and neck metastasis classification, while the Memorial Sloan-Kettering Cancer Center classification system was used for the classification of cervical lymphatic chain. RESULTS: Two patients (3.17%) had subglottic, 19 (30.15%) had glottic, and 42 (66.66%) had supraglottic lesions. A total of 732 lymph nodes were removed from three regions in RND group, while 1042 lymph nodes were removed in LND group. CONCLUSION: Our study results showed that the number of lymph nodes removed by LND was sufficient and RBD was not superior in terms of the number of lymph nodes removed.

Development, Validation, and Reliability of the Teacher-Reported Pediatric Voice Handicap Index.

PURPOSE: The purpose of this study was to develop a novel teacher-reported pediatric voice outcome measure and to investigate its psychometric properties. METHOD: In the first stage, a new instrument, the Teacher-Reported Pediatric Voice Handicap Index (TRPVHI), was developed. After item generation, a panel of experts evaluated the items to assess the content validity. Subsequently, the final version of the preliminary instrument was applied to teachers of 306 children (57 dysphonic and 249 vocally healthy) between the ages of 4 and 11 years. Eventually, the construct validity, criterion-related validity, test-retest reliability, and internal consistency of the developed instrument were examined. RESULTS: The items with a content validity ratio less than .8 were modified or removed, and accordingly, the preliminary version of the index was finalized. After the application of the preliminary version, item reduction was made based on the factor analysis. The index is composed of 27 questions and three subscales: Functional, Physical, and Emotional. A significant difference was observed between the dysphonic and vocally healthy children for the TRPVHI scores (p < .001). A positive moderate correlation was determined between the Pediatric Voice Handicap Index and TRPVHI scores. Correlation coefficients between the test and retest scores of the TRPVHI were in the range of .92-.98. Cronbach's alpha values computed to assess the internal consistency were in the range of .94-.98. CONCLUSIONS: The TRPVHI is the only valid and reliable teacher-reported outcome measure of the effects of voice disorders on children. It is anticipated that the deployment of the TRPVHI in conjunction with other subjective tools, both in the initial evaluation and the follow-up of the treatment results, will allow a better understanding of the physical, functional, and emotional effects of voice disorders on children. Furthermore, it can potentially lead further research to enable the use of the TRPVHI for screening purposes.

Validity and Reliability of the Turkish SingingVoice Handicap Index-10.

OBJECTIVE: To evaluate the validity and reliability of the Turkish version of the Singing Voice Handicap Index-10 (SVHI-10). STUDY DESIGN: Cross-sectional study. METHODS: Two hundred singers consisting of a control group (n = 136) without voice complaints and a study group (n = 64) diagnosed with a voice disorder served as participants. To detect test-retest reliability, 97 participants (representing a portion of both the control and study group participants) completed the index twice with a minimum of a one-week interval between each completion. Internal consistency was confirmed using Cronbach's alpha coefficient. To complete a clinical validity assessment, scores from the control group participants were compared with scores from the study group participants. To determine content validity, the correlation between the SVHI-10 and the participants' perceptions of singing voice complaints was researched. The sensitivity and specificity of the SVHI-10/Turkish version were calculated using a receiver operating characteristic curve analysis. RESULTS: Cronbach's alpha coefficient, which was equal to 0.91, proved to have excellent internal consistency. Item-total correlations were found in the range of 0.55 to 0.76. The mean SVHI-10/Turkish score for the control group was 8.14 ± 5.4, whereas this value was significantly higher in the study group (20.54 ± 6.9, P < 0.001). The Pearson product-moment correlation test indicated that the Turkish SVHI-10 is a reliable tool (r = 0.90, n = 97, P < 0.001). The area under curve of the Turkish SVHI-10 was 0.95. The optimal cut-off point was found to be 11.5, with a sensitivity of 95.8% and a specificity of 83.2%. CONCLUSIONS: The Turkish version of the SVHI-10 has proven to be a reliable and valid instrument for evaluating the self-perception of a singer in relation to voice problems. It can also be used as a quick screening tool because a score on the SVHI-10 higher than 11.5 is indicative of an abnormal singer's perceived voice handicap.

Reliability and Validity of the Turkish Reflux Symptom Index.

OBJECTIVE: To validate and assess reliability of the Turkish Reflux Symptom Index (T-RSI). STUDY DESIGN: Cross-sectional case-control study. MATERIALS AND METHODS: A Turkish version of the original American English RSI was developed. One hundred thirty-two patients with a Reflux Finding Score (RFS) > 7, and 162 healthy controls (HC) with RFS ≤7 were included in the study. To assess reliability, the T-RSI was scored twice, within a 7-14 day window. For construct validity, the scores obtained in the study group were compared to the scores from the HC group. A correlation between RSI and RFS was assessed to determine content validity. Finally, sensitivity and specificity of the index was calculated using a receiver operating characteristic curve analysis. RESULTS: The T-RSI showed excellent internal consistency (Cronbach`s α = 0.912). Item-total correlation coefficients ranged between 0.572 and 0.773. The Pearson product-moment correlation test indicated that the T-RSI is a reliable tool (r = 0.931, n = 107, P < 0.001). There were significant difference between the study group and the HC group for the mean RSI scores (18.15 ± 7.31 and 7.88 ± 5.32, P < 0.001 respectively). The mean RFS score in the patients was 12.57 and the correlation between RFS score and RSI score was high (r = 0.704). According to the receiver operating characteristic curve analysis the area under curve of the T-RSI was 0.892. The optimal cut-off value was 12.5 with a sensitivity of 82.6% and a specificity of 84.6%. CONCLUSION: The T-RSI is an easily administered, reliable, and valid instrument for assessing symptoms thought to be related to laryngopharyngeal reflux. A score of T-RSI greater than 12.5 is similar to an RSI score of >13 considered symptomatic for laryngopharyngeal reflux.

Laryngoscopic Examination During the COVID-19 Pandemic: Turkish Voice Speech and Swallowing Disorders Society and Turkish Professional Voice Society Recommendations.

COVID-19 is highly transmissible and spreads rapidly in the population. This increases the occupational risk for health care workers. In otolaryngology clinic practice, patients with upper respiratory tract infection symptoms are common. Also, routine head and neck examinations such as oral cavity examination, nasal/nasopharyngeal examination, or video laryngostroboscopic evaluation are highly risky because of the aerosol formation. To emphasize this issue, two leading otolaryngology organizations in Turkey; 'Voice Speech and Swallowing Disorders Society', and 'Professional Voice Society' gathered a task force. This task force aimed to prepare a consensus report that would provide practical recommendations of the safety measurements during routine clinical care of laryngology patients. To fulfill this, universal aim, on the 2nd and 9th of May 2020, two web-based meetings were conducted by 20 expert physicians. This eighteen items list was prepared as an output.

[The efficacy of preoperative local bupivacain application on postoperative pain in patients who had undergone tonsillectomy]. / Tonsillektomi uygulanmis olgularda ameliyat öncesi lokal bupivacain uygulamasinin ameliyat sonrasi agri üzerine etkisi.

OBJECTIVES: To investigate the efficacy of preoperative local bupivacain application on postoperative pain and complications in tonsillectomy. PATIENTS AND METHODS: Fourty-five patients (mean age 8.07+/-3.34 years; range 4 to 20 years) who had undergone tonsillectomy were included in this study and they were divided into two groups. Study group included 30 patients and were preoperatively injected with 2.5 ml 0.5% bupivacain in each peritonsillar area. Control group included 15 patients and were injected with 0.9% NaCl. Both groups were compared with respect to operation and anesthesia duration, intraoperative blood loss and postoperative pain parameters (15. minute, 1, 4, 12, 16. and 24. hours). RESULTS: There were no statistically significant differences in operation or anesthesia duration and intraoperative bleeding between two groups (p>0.05). Postoperative pain at the 15th minute, and 1st hour, were significantly lower in controls when compared with study group (p<0.05). While these values were significant for the postoperative 15th minute, they were not significant for the 1st hour. Postoperative pain score at the 4th hour was significantly lower in the study group when compared with the control group (p<0.05). Postoperative pain score at the 24th hour was considerably lower in the study group when compared with the control group (p<0.01). CONCLUSION: Preoperative local bupivacain application reduces postoperative pain especially at the 24th hour in patients who have undergone tonsillectomy.

[Squamous cell carcinoma originating from the nasal septum: a case report]. / Nazal septumdan kaynaklanan skuamöz hücreli karsinom: olgu sunumu.

A 73-year-old male patient presented with a mass that developed in the left nasal cavity and projected out the nasal vestibule. Nasal endoscopy showed a polypoid, hyperemic mass that originated from the caudal end of the septum and almost filled the left nasal passage. Histopathologic diagnosis of the biopsy specimen taken from the lesion was squamous cell carcinoma. Ultrasonography of the neck showed no lymphadenopathy. The mass was excised via a lateral rhinotomy and the defect site was reconstructed with a nasolabial sulcus flap. No postoperative complications or recurrences were encountered during a follow-up of six months.

Extending Myringotomy Patency with Topical Everolimus in Rats.

BACKGROUND: Everolimus is an immunosuppressant agent that has antiproliferative properties and negative effects on wound healing. The effect of everolimus use to delay the closure time of myringotomy is not known. OBJECTIVES: The aim of the study was to evaluate the impact of topical everolimus on myringotomy patency and to investigate its histopathologic effects on the tympanic membrane. MATERIAL AND METHODS: Twenty Sprague-Dawley rats were bilaterally myringotomized with a myringotomy knife. Gelfoam soaked in 0.05% everolimus in a microemulsion formulation was applied to the right myringotomy site of the rats for 10 min (the everolimus group). The myringotomy sites of the left ears were treated with sterile saline topically (the control group). The tympanic membranes were routinely examined otomicroscopically every other day for 31 days. The membranes were then harvested and evaluated histologically after 31 days. RESULTS: All tympanic membranes were closed by the 15(th) day in the control group, while in the everolimus group the myringotomy remained open in five rats (25%) on day 31. The mean durations of myringotomy patency in the everolimus group and control group were 20.90 ± 7.85 and 10.10 ± 3.14 days, respectively. The difference was found to be statistically significant (p < 0.01). In the histopathological examination of the tympanic membranes, there was less fibrosis and less inflammation in the everolimus group than in the control group (p < 0.01). CONCLUSIONS: Topical everolimus application is effective in extending myringotomy patency in rat tympanic membranes. Inflammatory reactions and fibrosis in the lamina propria were observed to be significantly less when topical everolimus was used.

Voice characteristics associated with polycystic ovary syndrome.

OBJECTIVES/HYPOTHESIS: To test the assumption that voice is changed in polycystic ovary syndrome (PCOS) and identify changes that occur. STUDY DESIGN: Cross-sectional pilot study. METHODS: Thirty patients with PCOS and a control group of 22 age-matched and body mass index-matched healthy women were included. Demographic data, anthropometric measurement, serum androgens, and Voice Handicap Index-10 were determined. Transnasal fiberoptic laryngoscopy and rigid stroboscopy were performed. Supraglottic hyperfunction was assessed during fiberoptic laryngoscopy. Presence of supraglottic hyperfunction was interpreted as abnormal muscle tension pattern. Glottal closure configuration and vibratory wave characteristics were evaluated via stroboscopy. Acoustic analysis was performed with the Dr. Speech software program version 4 (Tiger DRS Inc., Seattle, WA). RESULTS: Voice complaints and acoustic parameters were similar between groups, whereas serum androgens were significantly higher in patients (P < 0.001). Laryngeal examination detected pathology in 17 (56.7%) patients and two (9.1%) controls (P < 0.001). Fiberoptic examination determined supraglottic hyperfunction in 11 patients but in only two controls (P = 0.023). In stroboscopy, incomplete glottal closure configuration and impaired vocal fold vibration were present in 10 and 11 patients, respectively, whereas only one control had glottal closure abnormality and none of the controls had abnormal vibration (P = 0.028 and P = 0.001, respectively). CONCLUSION: Abnormal muscle tension patterns and impaired vocal fold vibration are frequent among patients with PCOS; but they are not accompanied by increased vocal symptoms or deteriorated acoustic voice parameters. This may be important for professional voice users or in extensive or extraordinary voice use demands in patients with PCOS. LEVEL OF EVIDENCE: 3b. Laryngoscope, 126:2067-2072, 2016.

Efficacy of continuous positive airway pressure on middle ear atelectasis: A double-blind placebo-controlled clinical trial.

OBJECTIVES/HYPOTHESIS: To investigate the effects of continuous positive airway pressure (CPAP) treatment on patients with middle ear atelectasis. STUDY DESIGN: Prospective, double-blind, randomized, placebo-controlled study. METHODS: Fifty-four patients with middle ear atelectasis were randomized to receive CPAP treatment with a pressure level of either 14 cm H2 O (CPAP group) or 0 cm H2 O (placebo group) once per week for a period of 3 hours for 4 sessions. Outcome measures included otomicroscopic examination as well as tympanometric and audiometric evaluation. Patients were followed for 6 months. RESULTS: The CPAP group included 35 atelectatic ears, and the placebo group included 32 atelectatic ears. More ears recovered to normal tympanic membrane or regressed to grade 1 atelectasis in the CPAP group than in the placebo group during all follow-up visits (P < .05). There was a statistically significant increase in the middle ear pressure values of the patients in the CPAP group compared to the placebo group at week 5, month 3, and month 6 (P < .05). There was no significant difference in middle ear pressure values between follow-up visits in the CPAP group (P > .05). Significant improvement of pure-tone air-conduction threshold averages were found in the CPAP group compared to the placebo group at month 6 (P < .05). CONCLUSIONS: CPAP is a safe, well-tolerated way of applying positive pressure to the middle ear for patients with middle ear atelectasis. It contributes to significant improvement in middle ear pressure of these patients, also resulting in an improved degree of atelectasis. LEVEL OF EVIDENCE: 1b. Laryngoscope, 126:1649-1655, 2016.

Voice outcomes following treatment of benign midmembranous vocal fold lesions using a nomenclature paradigm.

OBJECTIVES/HYPOTHESIS: Benign midmembranous vocal fold lesions (BMVFLs) are common voice disorders, but interpretation of outcomes following treatment is difficult due to the lack of a standardized nomenclature system for these lesions. Outcome results are increasingly important to third party payers. This study aimed to investigate the outcomes of patients with BMVFLs using a previously validated nomenclature, and to provide incidences and outcome results for each diagnosis. METHODS: A retrospective chart review of BMVFL patients was performed. Treatment was individualized but typically involved implementation of nonsurgical therapy followed by phonomicrosurgery as needed. A previously reported BMVFL stratification system was used. RESULTS: A total of 224 patients with BMVFLs were studied. Sixty-seven percent of all patients with a BMVFL underwent phonomicrosurgery. The most common BMVFL types were polyp and nonspecific vocal fold lesion. Pseudocyst represented 0.9% of the cohort. The Voice Handicap Index-10 (VHI-10) and acoustic data demonstrate a high degree of treatment success. The mean change in VHI-10 was greatest for cyst-subepithelial and polyp. Fibrous mass-ligamentous patients had the smallest mean change in VHI-10. Mean post-treatment VHI-10 scores of all the lesions except fibrous mass-ligamentous were within normal limits (<11). CONCLUSIONS: This study represents the first outcomes-based report of BMVFLs using a strictly defined nomenclature system for stratification of lesions. Ligamentous fibrous mass lesions have a decreased response to treatment compared to all other lesions. This study demonstrates the ability to return most BMVFL patients to normal speaking voice capabilities following treatment. LEVEL OF EVIDENCE: 4.