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Nucleic Acids Res ; 51(W1): W343-W349, 2023 07 05.
Artículo en Inglés | MEDLINE | ID: mdl-37178004

RESUMEN

Predicting protein localization and understanding its mechanisms are critical in biology and pathology. In this context, we propose a new web application of MULocDeep with improved performance, result interpretation, and visualization. By transferring the original model into species-specific models, MULocDeep achieved competitive prediction performance at the subcellular level against other state-of-the-art methods. It uniquely provides a comprehensive localization prediction at the suborganellar level. Besides prediction, our web service quantifies the contribution of single amino acids to localization for individual proteins; for a group of proteins, common motifs or potential targeting-related regions can be derived. Furthermore, the visualizations of targeting mechanism analyses can be downloaded for publication-ready figures. The MULocDeep web service is available at https://www.mu-loc.org/.


Asunto(s)
Proteínas , Programas Informáticos , Aminoácidos/metabolismo , Biología Computacional/métodos , Transporte de Proteínas , Proteínas/química , Internet
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