Geometrically Amplified Wetting of Silver Nanosolder on a Rough Diamond Surface.

The wetting behavior of silver at the nanoscale on a textured diamond substrate is not absolutely roughness-dependent in printing diamond chips, tough bioimplant coating, and joining for cutting tool industries. This study uses a molecular dynamics simulation to capture the stochastic wetting behavior toward precision for given geometries. It is deduced that the metalophilic character of molten silver is increased with an increase in roughness on sinusoidal contoured diamond substrates rather than orthogonal pillars of the same roughness until an equilibration time of 210 ps at a temperature of 950 K. Increasing the roughness after the equilibrium time causes a supermetalophilic angle of 13° for the sinusoid at 500 ps, and the orthogonal design causes the Wenzel state. Therefore, wetting states are metastable and ultimately depend upon the wetting time and geometry rather than the roughness only. A high joining strength creates a long-lasting coating, owing to the high surface energy of the textured surface. This study presents effective thin seam development in the least possible time of 230 ps and silver consumption at the nanoscale for supermetalophilic and metalophobic coatings in electronic packaging.

Effect of protein adsorption on the dissolution kinetics of silica nanoparticles.

Nanoparticulate systems in the presence of proteins are highly relevant for various biomedical applications such as photo-thermal therapy and targeted drug delivery. These involve a complex interplay between the charge state of nanoparticles and protein, the resulting protein conformation, adsorption equilibrium and adsorption kinetics, as well as particle dissolution. SiO2 is a common constituent of bioactive glasses used in biomedical applications. In this context, the dissolution behavior of silica particles in the presence of a model protein, bovine serum albumin (BSA), at physiologically relevant pH conditions was studied. Sedimentation analysis using an analytical ultracentrifuge showed that BSA in the supernatant solution is not affected by the presence of silica nanoparticles. However, zeta potential measurements revealed that the presence of the protein alters the particles' charge state. Adsorption and dissolution studies demonstrated that the presence of the protein significantly enhances the dissolution kinetics via interactions of positively charged amino acids in the protein with the negative silica surface and interaction of BSA with dissolved silicate species. Our study provides comprehensive insights into the complex interactions between proteins and oxide nanoparticles and establishes a reliable protocol paving the way for future investigations in more complex systems involving biological solutions as well as bioactive materials.

Facile Synthesis of Gallium (III)-Chitosan Complexes as Antibacterial Biomaterial.

Even though antibiotic treatment remains one of the most common tools to handle bacterial infections, the excessive antibiotic concentration at the target site may lead to undesired effects. Aiming at the fabrication of antibiotic-free biomaterials for antibacterial applications, in this work, we propose the synthesis of gallium (III)-chitosan (Ga (III)-CS) complexes with six different gallium concentrations via an in situ precipitation method. Fourier Transform infrared spectroscopy indicated the chelation of chitosan with Ga (III) by peak shifts and changes in the relative absorbance of key spectral bands, while energy-dispersive X-ray spectroscopy indicated the homogenous distribution of the metal ions within the polymer matrix. Additionally, similar to CS, all Ga (III)-CS complexes showed hydrophobic behavior during static contact-angle measurements. The antibacterial property of the complexes against both Gram-negative and Gram-positive bacteria was positively correlated with the Ga (III) concentration. Moreover, cell studies confirmed the nontoxic behavior of the complexes against the human osteosarcoma cell line (MG-63 cells) and mouse embryonic fibroblasts cell line (MEFs). Based on the results of this study, new antibiotic-free antibacterial biomaterials based on Ga (III)-CS can be developed, expanding the scope of CS applications in the biomedical field.