Detalles de la búsqueda
1.
Antiviral Activity and Crystal Structures of HIV-1 gp120 Antagonists.
Int J Mol Sci;
23(24)2022 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36555641
2.
In Vitro and In Vivo Pharmacological Characterization of a Novel TRPM8 Inhibitor Chemotype Identified by Small-Scale Preclinical Screening.
Int J Mol Sci;
23(4)2022 Feb 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-35216186
3.
Design, synthesis, and antiviral activity of a series of CD4-mimetic small-molecule HIV-1 entry inhibitors.
Bioorg Med Chem;
32: 116000, 2021 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33461144
4.
Generation, optimization and characterization of novel anti-prion compounds.
Bioorg Med Chem;
28(21): 115717, 2020 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33065443
5.
Design, synthesis and evaluation of small molecule CD4-mimics as entry inhibitors possessing broad spectrum anti-HIV-1 activity.
Bioorg Med Chem;
24(22): 5988-6003, 2016 11 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27707628
6.
Targeting Virus-Induced Reprogrammed Cell Metabolism via Glycolytic Inhibitors: An Effective Therapeutic Approach Against SARS-CoV-2.
Mini Rev Med Chem;
23(2): 120-130, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-35713132
7.
Design and Synthesis of Fsp3-Enriched Spirocyclic-Based Biological Screening Compound Arrays via DOS Strategies and Their NNMT Inhibition Profiling.
ChemMedChem;
17(24): e202200394, 2022 12 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-36193863
8.
Comparative Pharmacokinetics of a Dual Inhibitor of HIV-1, NBD-14189, in Rats and Dogs with a Proof-of-Concept Evaluation of Antiviral Potency in SCID-hu Mouse Model.
Viruses;
14(10)2022 10 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-36298823
9.
Design and Characterization of Novel Small Molecule Activators of Excitatory Amino Acid Transporter 2.
ACS Med Chem Lett;
13(10): 1628-1633, 2022 Oct 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-36262387
10.
Design, Synthesis, and Antiviral Activity of the Thiazole Positional Isomers of a Potent HIV-1 Entry Inhibitor NBD-14270.
ChemMedChem;
17(22): e202200344, 2022 11 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-36097139
11.
Structure-Based Identification and Biological Characterization of New NAPRT Inhibitors.
Pharmaceuticals (Basel);
15(7)2022 Jul 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-35890155
12.
Discovery of the 4-aminopiperidine-based compound EM127 for the site-specific covalent inhibition of SMYD3.
Eur J Med Chem;
243: 114683, 2022 Dec 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36116234
13.
Phosphorus-based functional groups as hydrogen bonding templates for rotaxane formation.
J Am Chem Soc;
133(31): 12304-10, 2011 Aug 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-21718069
14.
Virtual screening based identification of novel small-molecule inhibitors targeted to the HIV-1 capsid.
Bioorg Med Chem;
19(1): 77-90, 2011 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21168336
15.
Polymorphisms in the transforming growth factor beta 1 pathway in relation to colorectal cancer progression.
Genes Chromosomes Cancer;
49(3): 270-81, 2010 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-19998449
16.
Design of gp120 HIV-1 entry inhibitors by scaffold hopping via isosteric replacements.
Eur J Med Chem;
224: 113681, 2021 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34246921
17.
Discovery of Highly Potent Fusion Inhibitors with Potential Pan-Coronavirus Activity That Effectively Inhibit Major COVID-19 Variants of Concern (VOCs) in Pseudovirus-Based Assays.
Viruses;
14(1)2021 12 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-35062273
18.
Bladder cancer risk in painters: a meta-analysis.
Occup Environ Med;
67(8): 568-73, 2010 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-20647380
19.
BioCores: identification of a drug/natural product-based privileged structural motif for small-molecule lead discovery.
Mol Divers;
14(1): 193-200, 2010 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-19468851
20.
Preclinical Optimization of gp120 Entry Antagonists as anti-HIV-1 Agents with Improved Cytotoxicity and ADME Properties through Rational Design, Synthesis, and Antiviral Evaluation.
J Med Chem;
63(4): 1724-1749, 2020 02 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-32031803