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1.
ACS Omega ; 9(11): 13482, 2024 Mar 19.
Artículo en Inglés | MEDLINE | ID: mdl-38524445

RESUMEN

[This corrects the article DOI: 10.1021/acsomega.3c02009.].

2.
ACS Omega ; 8(34): 30917-30928, 2023 Aug 29.
Artículo en Inglés | MEDLINE | ID: mdl-37663464

RESUMEN

Aluminum corrosion was inhibited by myrrh extract when it was placed in a solution of 1 M HCl. Several procedures were used for these tests, including weight loss WL, potential dynamic polarization PL, and electrochemical impedance EIS in addition to theoretical calculations like density functional theory (DFT), Fukui functions, and Monte Carlo simulation. Fourier transform infrared spectroscopy was used to analyze the compositional surface of Al. Scanning electron microscopy was used to determine the shape of the Al surface. The inhibition rate of Al corrosion in HCl with varying myrrh extract contents at 25-45 °C was studied. An analysis of the PL curves indicates that myrrh extract is an inhibitor of mixed type. Upon increasing the concentration of myrrh, the inhibition efficiency increased. Moreover, rising temperatures decrease inhibition efficiency. It was discovered that the inhibition process follows the Langmuir isotherm, demonstrating that a monolayer has formed on the surface of aluminum. Theoretical and practical studies proved the validity of the conclusions.

3.
Int J Biol Macromol ; 184: 648-665, 2021 Aug 01.
Artículo en Inglés | MEDLINE | ID: mdl-34102239

RESUMEN

Nanofibers have a particular benefit when delivering a spectrum of therapeutic drugs for diverse biomedical applications. Nanofibers are easily fabricated from cellulose acetate, chitosan, polycaprolactone, and other polymers with regulated morphology and release profiles due to nanotechnology's recent advancement. This review will provide the latest approaches to the fabrication of electrospun nanofibers containing herbal extracts, antimicrobial peptides, and antibiotics for wound-healing potential. Besides, synthesis and evaluation of nanofibrous mats, including conducting polymer and evaluate their possibility for wound healing. In addition, nanofibers are loaded with some drugs for skin cancer treatment and contain growth factors for tissue regeneration. Also, the current two-dimensional nanofibers limitations and the various techniques for convert two-dimensional to three-dimension nanofibers to avoid these drawbacks. Moreover, the future direction in improving the three-dimensional structure and functionality has been including.


Asunto(s)
Nanofibras/química , Polisacáridos/química , Cicatrización de Heridas/efectos de los fármacos , Animales , Antibacterianos/química , Antibacterianos/farmacología , Sistemas de Liberación de Medicamentos , Diseño de Fármacos , Humanos , Extractos Vegetales/química , Extractos Vegetales/farmacología , Proteínas Citotóxicas Formadoras de Poros/química , Proteínas Citotóxicas Formadoras de Poros/farmacología
4.
Int J Biol Macromol ; 190: 417-432, 2021 Nov 01.
Artículo en Inglés | MEDLINE | ID: mdl-34450151

RESUMEN

Since chitosan's excellent pharmacokinetic and chemical properties, it is an attractive and promising carbohydrate biopolymer in biomedical applications. Chitosan's beneficial function in the defense and propagation of pancreatic ß cells, reducing hyperglycemia, and avoiding diabetes mellitus associated with impaired lipid metabolism has been demonstrated in several studies. Additionally, chitosan has also been used in various nanocarriers to deliver various antidiabetic drugs to reduce glucose levels. Herein, the first to provide the currently available potential benefits of chitosan in diabetes mellitus treatment focuses on chitosan-based nanocarriers for oral administration of various antidiabetic drugs nasal and subcutaneous passages. Moreover, chitosan is used to activate and deliver stem cells and differentiate them into cells similar to pancreatic beta cells as a new type of treatment for type one diabetes mellitus. The results of this review will be helpful in the development of promising treatments and better control of diabetes mellitus.


Asunto(s)
Tecnología Biomédica , Quitosano/química , Diabetes Mellitus/tratamiento farmacológico , Sistemas de Liberación de Medicamentos , Hipoglucemiantes/administración & dosificación , Hipoglucemiantes/uso terapéutico , Células Madre/citología , Glucosa/metabolismo , Humanos
5.
Int J Biol Macromol ; 193(Pt B): 1532-1540, 2021 Dec 15.
Artículo en Inglés | MEDLINE | ID: mdl-34732305

RESUMEN

The Severe Acute Respiratory Syndrome-related Coronavirus 2 (COVID-19 or SARS-CoV-2) epidemic is professed as world disaster producing a worrying increasing mortality, particularly amongst vulnerable humans worldwide. Whether COVID-19 has a strong ability for acceptable genetic flexibility that amended for breaking immune responses quickly, it is critical to understand the adaptation mechanism between viruses and hosts that allows individuals to follow viral development. This can contribute to finding the appropriate treatment to combat the epidemic. However, the present information about viral adaptation mechanisms in hosts is still insufficient, and future investigations may reveal the unknown. Mutations and genetic variations are naturally occurring; however, the current knowledge about their mechanism and pathways still has many secrets. The present review also provides insights into the immune system, immunological memory, and the development of the COVID-19 vaccine. Other fighting methods against COVID-19 are also highlighted. The potential of antibodies, natural metabolites, and current suggest vaccines were applied to the face of this new threat.


Asunto(s)
Vacunas contra la COVID-19 , COVID-19 , Interacciones Huésped-Patógeno/inmunología , Memoria Inmunológica , SARS-CoV-2/fisiología , COVID-19/inmunología , COVID-19/mortalidad , COVID-19/prevención & control , Vacunas contra la COVID-19/inmunología , Vacunas contra la COVID-19/uso terapéutico , Humanos
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