Meta-Analysis of the Relationship between TNF-α (-308G/A) and IL-10 (-819C/T) Gene Polymorphisms and Susceptibility to Dengue.

OBJECTIVE: This study determined whether tumor necrosis factor alpha (TNF-α) and Interleukin-10 (IL-10) polymorphisms are associated with susceptibility to dengue. METHODS: a systematic review with meta-analysis was conducted of the associations between the TNF-α (-308G/A) and IL-10 (-819C/T) polymorphisms and dengue. RESULTS: A total of eight case-controls studies involving 384 individuals with symptomatic dengue, 571 individuals with dengue hemorrhagic fever, and 995 healthy controls were considered in the meta-analysis. There was no significant association between TNF-α (-308G/A) and IL-10 (-819C/T) polymorphism and dengue in overall population. However, stratifying meta-analysis by groups, the meta-analysis revealed association between the TNF-α -308 G/G (OR: 1.62, CI: 1.02-2.57, p = 0.04) genotype and allele G (OR: 1.62, CI: 1.04-2.55, p = 0.03) that confers susceptibility to symptomatic dengue, while the TNF-α -308 G/A genotype (OR: 0.69, CI = 0.39-0.99, p = 0.04) and allele A (OR: 0.64, CI: 0.41-1.00, p = 0.05) confers protection to symptomatic dengue. No difference was observed for the TNF-α (-308) and IL-10 (-819C/T) polymorphisms in the comparisons of hemorrhagic dengue versus control and hemorrhagic dengue versus symptomatic dengue. CONCLUSION: This meta-analysis showed that TNF-α (-308) polymorphism is associated with dengue symptomatic susceptibility.

Health promotion of Street Clinic workers: convergent care research.

OBJECTIVE: To develop a health promotion action for Street Clinic workers. METHOD: Qualitative research which used the Convergent Care Research methodology. The data collection was conducted through participant observation and convergence groups, from May to October 2021, with 39 workers from six teams of the Street Clinic. Data analysis followed the stages of apprehension, synthesis, theorization, and transfer. RESULTS: Some integrativepractices such as, stretching, group dynamics, dance, music, massage and cinema were suggested as interventions to be implemented. Given the need, Reichian stretching was developed as an intervention which favored body awareness, promoting the well-being of workers. CONCLUSION: The workers presented a conception of health promotion related to access to services and guarantee of rights. Reichian stretching provided a space for care and reflection on caring and respecting limits, favoring the body awareness and promoting relaxation.

Psychopathological symptoms and work status of Southeastern Brazilian nursing in the context of COVID-19. / Sintomas psicopatológicos e situação laboral da enfermagem do Sudeste brasileiro no contexto da COVID-19.

OBJECTIVE: to evaluate the relationship between psychopathological symptoms and the work situation of nursing professionals in the Southeast Region, Brazil, in the context of the COVID-19 pandemic. METHOD: an observational and cross-sectional study with virtual and snowball data collection from April to July 2020. A questionnaire containing socio-demographic and labor data and the psychopathological symptoms assessment scale (psychoticism, obsessiveness/compulsivity, somatization, and anxiety) were applied. Descriptive and inferential statistics were used to analyze the data. RESULTS: among the 532 participants, there was a relationship between weekly workload and psychoticism. All domains of the scale were associated with embarrassment and/or violence in the course of work and receiving psychological/emotional support from the institution where the individual works/studies. CONCLUSION: the age group, heavy workload, experienced violence and lack of psychological support during the pandemic were associated with increased psychopathological symptoms among nursing professionals. It is suggested the creation of institutional guidelines aimed at the reception and follow-up of these demands.

Sofrimento mental, suporte familiar e empoderamento de pessoas transgênero / Sufrimiento mental, apoyo familiar y empoderamiento de personas transgénero / Mental suffering, family support and empowerment of transgender people

Resumo Objetivo Identificar a presença de sofrimento mental, o suporte familiar e o empoderamento de pessoas transgênero residentes no Estado de Alagoas, Brasil. Métodos Estudo transversal, descritivo, quantitativo. Pessoas transgênero maiores de 18 anos que residiam no Estado de Alagoas foram incluídas no estudo. As entrevistas foram realizadas na plataforma Google Meet, mediante agendamento telefônico e WhatsApp. Foram utilizados: Questionário de identificação, Inventário de Ansiedade Traço-Estado, Escala de Depressão, Inventário de Percepção de Suporte Familiar e Escala de Empoderamento. Os dados foram inseridos no software Statistical Package For The Social Sciences 23, e analisados por meio de cálculo de frequências, médias, desvio-padrão e teste de Pearson Chi-Square. Resultados Foram entrevistadas 37 pessoas transgênero, com idade média de 27,35 anos, cor autorreferida preta/parda (91,8%), apresentando ideação suicida no último ano (48,6%), tentativa de suicídio (35,1%), risco para depressão (64,9%) e baixo suporte familiar (94,6%). Mulheres transgênero e pansexuais apresentaram maior traço de personalidade ansiosa e mulheres transgênero e bissexuais vivenciavam um maior estado ansioso. Houve maior comprometimento em pessoas heterossexuais na dimensão Afetivo-Consistente; em pessoas pansexuais, na dimensão Adaptação Familiar; em pessoas bissexuais, na dimensão Autonomia Familiar. O Ativismo Comunitário apresentou-se mais comprometido no empoderamento de pessoas transgênero. Conclusão As fragilidades nas relações familiares, aliado às condições de violência e preconceito vivenciados frente à dificuldade de muitos em conviver com a diversidade pode estar contribuindo para o sofrimento mental de pessoas transgênero. É preciso pensar em ações voltadas para a promoção do seu empoderamento, numa rede de apoio interna e externa à família.

Resumen Objetivo Identificar la presencia de sufrimiento mental, apoyo familiar y empoderamiento de personas transgénero residentes en el estado de Alagoas, Brasil. Métodos Estudio transversal, descriptivo, cuantitativo. Se incluyeron en el estudio personas transgénero mayores de 18 años que residían en el estado de Alagoas. Las entrevistas se realizaron en la plataforma Google Meet, previamente programadas por teléfono y WhatsApp. Se utilizaron los siguientes instrumentos: Cuestionario de Identificación, Cuestionario de Ansiedad Estado Rasgo, Escala de Depresión, Cuestionario de Percepción de Apoyo Familiar y Escala de Empoderamiento. Los datos se ingresaron al software Statistical Package For The Social Sciences 23 y se analizaron mediante cálculo de frecuencias, promedios, desviación típica y prueba de Pearson Chi-Square. Resultados Se entrevistaron 37 personas transgénero, de 27,35 años de edad promedio, color autopercibido negro/pardo (91,8 %), que presentaron ideación suicida en último año (48,6 %), intento de suicidio (35,1 %), riesgo de depresión (64,9 %) y bajo apoyo familiar (94,6 %). Las mujeres transgénero y pansexuales presentaron mayor rasgo de personalidad ansiosa y las mujeres transgénero y bisexuales tuvieron más vivencias de estado ansioso. Hubo una mayor afectación en personas heterosexuales en la dimensión Afectivo-consistente; en personas pansexuales en la dimensión Adaptación familiar, y en personas bisexuales en la dimensión Autonomía familiar. El activismo comunitario se vio más comprometido en el empoderamiento de personas transgénero. Conclusión Las debilidades en las relaciones familiares, junto con las condiciones de violencia y prejuicio que enfrentan las personas transgénero ante la dificultad de muchos de convivir con la diversidad, puede contribuir con su sufrimiento mental. Es necesario pensar en acciones para promover su empoderamiento, mediante una red de apoyo interna y externa a la familia.

Abstract Objective Identify the presence of mental suffering, family support and empowerment of transgender people living in the State of Alagoas, Brazil. Methods Cross-sectional, descriptive, quantitative study. Transgender people over 18 years old who lived in the State of Alagoas were included in the study. The interviews were carried out on the Google Meet platform, through telephone and WhatsApp. The following instruments were used: Identification Questionnaire, State-Trait Anxiety Inventory, Depression Scale, Perceived Family Support Inventory and Empowerment Scale. The data were entered into the Statistical Package for the Social Sciences 23 software, and analyzed by calculating frequencies, means, standard deviation and the Pearson Chi-Square test. Results 37 transgender people were interviewed, with an average age of 27.35 years, self-reported black/brown color (91.8%), presenting suicidal ideation in the last year (48.6%), attempted suicide (35.1%), risk for depression (64.9%) and low family support (94.6%). Transgender and pansexual women presented a greater anxious personality trait and transgender and bisexual women experienced a greater anxious state. There was greater impairment in heterosexual people in the Affective-Consistent dimension; in pansexual people, in the Family Adaptation dimension; in bisexual people, in the Family Autonomy dimension. Community Activism was more committed to empowering transgender people. Conclusion The weaknesses in family relationships, combined with the conditions of violence and prejudice experienced in the face of the difficulty of many in living with diversity, may be contributing to the mental suffering of transgender people. Thoughts about actions aimed at promoting their empowerment are essential, in a support network that can be internal and external to their family.

Health promotion of Street Clinic workers: convergent care research / Promócion de la salud de los trabajadores del Consultorio en la Calle: investigación convergente asistencial / Promoção da saúde de trabalhadores do Consultório na Rua: pesquisa convergente assistencial

ABSTRACT Objective: To develop a health promotion action for Street Clinic workers. Method: Qualitative research which used the Convergent Care Research methodology. The data collection was conducted through participant observation and convergence groups, from May to October 2021, with 39 workers from six teams of the Street Clinic. Data analysis followed the stages of apprehension, synthesis, theorization, and transfer. Results: Some integrativepractices such as, stretching, group dynamics, dance, music, massage and cinema were suggested as interventions to be implemented. Given the need, Reichian stretching was developed as an intervention which favored body awareness, promoting the well-being of workers. Conclusion: The workers presented a conception of health promotion related to access to services and guarantee of rights. Reichian stretching provided a space for care and reflection on caring and respecting limits, favoring the body awareness and promoting relaxation.

RESUMEN Objetivo: Desarrollar acciones para promover la salud de los trabajadores de la Oficina de Calle. Método: Investigación cualitativa, que utilizó la metodología de Investigación Convergente Asistencial. La producción de información se llevó a cabo a través de la observación participante y grupos de convergencia, de mayo a octubre de 2021, con 39 trabajadores de seis equipos del consultorio en la calle. El análisis de datos siguió las etapas de aprehensión, síntesis, teorización y transferencia. Resultados: Se sucedieron algunas prácticas integrativas como intervenciones a implementar, estiramientos, dinámicas de grupos, danza, música, masaje, cine. Ante la necesidad se desarrolló el estiramiento reichiano como una intervención que favoreció la conciencia corporal, promoviendo el bienestar de los trabajadores. Conclusión: Los trabajadores presentaron una concepción de promoción de la salud relacionada con el acceso a servicios y la garantía de derechos. El estiramiento reichiano proporcionó un espacio de cuidado y reflexión sobre el cuidado y el respeto de los límites, favoreciendo la toma de conciencia corporal y promoviendo la relajación.

RESUMO Objetivo: Desenvolver ação de promoção à saúde do trabalhador do Consultório na Rua. Método: Pesquisa qualitativa que utilizou a metodologia da Pesquisa Convergente Assistencial. Para a coleta de dados, utilizou-se a observação participante e grupos de convergência, de maio a outubro de 2021. Participaram 39 trabalhadores de seis equipes do Consultório na Rua. A análise dos dados seguiu as etapas de apreensão, síntese, teorização e transferência. Resultados: Foram sugeridas como intervenções a serem implementadas algumas práticas integrativas, alongamento, dinâmica em grupo, dança, música, massagem, cinema. Visto a necessidade, desenvolveu-se como intervenção o alongamento reichiano, que favoreceu a tomada de consciência corporal, promovendo bem-estar dos trabalhadores. Conclusão: Os trabalhadores apresentaram uma concepção de promoção da saúde relacionada ao acesso aos serviços e à garantia de direitos. O alongamento reichiano proporcionou um espaço de cuidado e reflexão sobre o cuidado e respeito dos limites, favorecendo a tomada de consciência corporal e promoveu o relaxamento.

Práticas aplicadas nas escolas em situações de automutilação em adolescentes: protocolo de revisão de escopo / Practices applied in schools in situations of self-mutilation among adolescents: scope review protocol

OBJETIVO: Identificar as práticas aplicadas nas escolas em situações de autolesão não suicida em adolescentes. MÉTODO: A estratégia de busca será aplicada no Medical Literature Analysis and Retrieval System Online (MEDLINE/PubMed), Excerpta Medica Database (EMBASE/Elsevier); Cumulated Index in Nursing and Allied Health Literature (CINAHL/Ebsco); Scopus/Elsevier, Cochrane Library; Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) via Biblioteca Virtual em Saúde (BVS), Base de Dados de Enfermagem (BDENF); PsycINFO; Education Resources Information Center (ERIC); Web of Science Core Collection, Scientific Electronic Library Online (SCIELO), e na literatura cinzenta. Serão considerados artigos de pesquisas primárias, quantitativos e/ou qualitativos, sem limitações quanto à data da publicação e idioma. Os resultados serão inseridos no EndNote v.X9 e duplicatas serão removidas. O Rayyan QCRI20 será utilizado na seleção dos estudos. Esta será feita por dois revisores independentes de forma cega. Discordâncias serão resolvidas por consenso ou terceiro revisor. Será utilizado o diagrama de fluxo Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR). Os dados serão extraídos usando a ferramenta de extração na abordagem scoping review do Joanna Briggs Institute (JBI).

OBJECTIVE: Identify practices applied in schools in situations of non-suicidal self-injury in adolescents. METHOD: The search strategy will be applied in Medical Literature Analysis and Retrieval System Online (MEDLINE/PubMed), Excerpta Medica Database (EMBASE/Elsevier); Cumulated Index in Nursing and Allied Health Literature (CINAHL/Ebsco); Scopus/Elsevier, Cochrane Library; Latin America and the Caribbean Health Sciences Literature (LILACS) by Virtual Health Library (VHL), Nursing Database (BDENF); PsycINFO; Education Resources Information Center (ERIC); Web of Science Core Collection, Scientific Electronic Library Online (SCIELO), and gray literature. Primary, quantitative and/or qualitative research articles will be considered without restriction regarding publication date and language. Results will be entered into EndNote X9, and duplicates will be removed. The Rayyan QCRI20 will be used in the selection of studies. This will be done by two independent reviewers blindly. Disagreements will be resolved by consensus or a third reviewer. The Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) flowchart will be used. Data will be extracted using the extraction tool in the JBI scoping review approach.

Sintomas psicopatológicos e situação laboral da enfermagem do Sudeste brasileiro no contexto da COVID-19 / Psychopathological symptoms and work status of Southeastern Brazilian nursing in the context of COVID-19 / Síntomas psicopatológicos y situación laboral de la enfermería del Sureste brasileño en el contexto de la COVID-19

Resumo Objetivo avaliar a relação entre sintomas psicopatológicos e a situação laboral de profissionais de enfermagem da Região Sudeste do Brasil, no contexto da pandemia da COVID-19. Método estudo observacional e transversal com coleta de dados virtual e por meio de snowball nos meses de abril a julho de 2020. Aplicou-se um questionário contendo dados sociodemográficos, laborais e a escala de avaliação de sintomas psicopatológicos (psicoticismo, obsessividade/compulsividade, somatização e ansiedade). Foram utilizadas estatísticas descritivas e inferenciais para a análise dos dados. Resultados entre os 532 participantes, verificou-se relação entre carga horária de trabalho semanal e psicoticismo. Todos os domínios da escala associaram-se ao constrangimento e/ou violência no percurso de trabalho e recebimento de suporte psicológico/emocional da instituição onde o indivíduo trabalha/estuda. Conclusão a faixa etária, carga horária elevada, violência vivenciada e falta de suporte psicológico durante a pandemia associaram-se com o aumento dos sintomas psicopatológicos entre os profissionais de enfermagem. Sugere-se a criação de diretrizes institucionais voltadas ao acolhimento e acompanhamento dessas demandas.

Abstract Objective to evaluate the relationship between psychopathological symptoms and the work situation of nursing professionals in the Southeast Region, Brazil, in the context of the COVID-19 pandemic. Method an observational and cross-sectional study with virtual and snowball data collection from April to July 2020. A questionnaire containing socio-demographic and labor data and the psychopathological symptoms assessment scale (psychoticism, obsessiveness/compulsivity, somatization, and anxiety) were applied. Descriptive and inferential statistics were used to analyze the data. Results among the 532 participants, there was a relationship between weekly workload and psychoticism. All domains of the scale were associated with embarrassment and/or violence in the course of work and receiving psychological/emotional support from the institution where the individual works/studies. Conclusion the age group, heavy workload, experienced violence and lack of psychological support during the pandemic were associated with increased psychopathological symptoms among nursing professionals. It is suggested the creation of institutional guidelines aimed at the reception and follow-up of these demands.

Resumen Objetivo evaluar la relación entre síntomas psicopatológicos y la situación laboral de profesionales de enfermería de la Región Sureste de Brasil, en el contexto de la pandemia de la COVID-19. Método estudio observacional y transversal con recolección de datos virtual y por medio de snowball en los meses de abril a julio de 2020. Se aplicó un cuestionario que contenía datos sociodemográficos, laborales y la escala de evaluación de síntomas psicopatológicos (psicoticismo, obsesión/compulsión, somatización y ansiedad). Fueron utilizadas estadísticas descriptivas y de inferencia para el análisis de los datos. Resultados entre los 532 participantes, se verificó una relación entre la carga horaria de trabajo semanal y el psicoticismo. Todos los dominios de la escala se asociaron con incomodidad y/o violencia, en el transcurso del trabajo y el recibimiento de soporte psicológico/emocional de la institución, en donde el individuo trabaja/estudia. Conclusión el intervalo etario, la carga horaria elevada, la violencia experimentada y la falta de soporte psicológico, durante la pandemia se asociaron con el aumento de los síntomas psicopatológicos entre los profesionales de enfermería. Se sugiere la creación de directrices institucionales dirigidas al acogimiento y acompañamiento de esas demandas.

Evaluation of the quality of life and risk of suicide.

OBJECTIVE: To identify the socio-demographic profiles, suicidal ideation, the presence of mental disorders and the quality of life of patients using mental health services in Arapiraca, Alagoas, Brazil. METHOD: Interviews were conducted in family health units and the Psychosocial Attention Center. The sample included 202 mental disorder patients with a risk of suicide attempts, 207 mental disorder patients without a risk of suicide attempts and 196 controls. This study used an identification questionnaire, the abbreviated World Health Organization Quality of Life questionnaire, Beck's Suicidal Ideation Scale and the Mini International Neuropsychiatric Interview. RESULTS: Patients who had a mental disorder and a risk of suicide attempts tended to be single, had less education and lower family income, were not working and showed lower scores in quality of life domains; 73 of these patients had suicidal ideation in the previous week. Depressive disorders, manic episodes, hypomanic episodes, social phobias, obsessive compulsive disorder, post-traumatic stress disorder, psychotic syndromes and generalized anxiety disorder were more frequent and statistically significant for patients at risk for suicide attempts. CONCLUSION: The management of patients with a risk of suicide attempts must focus on individual patients because this risk is directly linked to changes in quality of life and the improvement of these patients' prognosis.

Características das tentativas de suicídio atendidas pelo serviço de emergência pré-hospitalar: um estudo epidemiológico de corte transversal / The characteristics of suicide attempts assisted by first responders: a cross-sectional epidemiological study

RESUMO Objetivo: Descrever o perfil das vítimas de tentativas de suicídio atendidas pelo Corpo de Bombeiros de um município do semiárido brasileiro. Métodos: Estudo transversal contendo dados do atendimento a vítimas de tentativas de suicídio, realizado pelos bombeiros militares do estado de Alagoas, no período de 1º de janeiro de 2000 a 31 de dezembro de 2017. Foram selecionadas as variáveis: sexo, idade, desfecho, intoxicação, uso de álcool, transtorno mental, estação do ano, dia da semana, horário, natureza da ocorrência e tempo de resposta, de transporte e total. Foram utilizados os testes qui-quadrado, exato de Fisher e Kruskal-Wallis. Resultados: Foram atendidas 144 vítimas de tentativas de suicídio. A frequência de atendimentos entre homens (n = 73; 50,7%) e mulheres (n = 71; 49,3%) foi semelhante. As mulheres apresentaram idade mais jovem (p < 0,001) e utilizaram o método da intoxicação (p < 0,001) duas vezes mais que os homens. A presença de transtorno mental (p = 0,04) foi mais comum entre os homens e o tempo consumido durante o atendimento pré-hospitalar foi maior entre eles, indicando que, possivelmente, as tentativas de suicídio cometidas por homens demandam maiores cuidados durante a assistência realizada pelos bombeiros. Conclusões: O perfil das vítimas de tentativas de suicídio apresentou frequência semelhante entre homens e mulheres, sendo as mulheres mais jovens. Nas mulheres, observou-se predomínio de intoxicações. Em homens, os transtornos mentais foram mais prevalentes. Além disso, fazem-se necessários o reconhecimento precoce dos casos de tentativas de suicídio, as principais formas de atuação e o preenchimento adequado das fichas de atendimento pré-hospitalar.

ABSTRACT Objective: To describe the profile of suicide attempts assisted by the Fire Department of a Brazilian semi-arid municipality. Methods: This is a cross-sectional study, containing data of care provided to victims of suicide attempts, conducted by the military firefighters of the state of Alagoas, from January 1, 2000 to December 31, 2017. The following variables were selected: sex, age, outcome, intoxication, alcohol use, mental disorder, season of the year, day of the week, schedule, nature of occurrence, response time, transportation time and total time. The chi-square, Fisher's exact test and Kruskal-Wallis tests were used. Results: Between 2000 and 2017, 144 victims of suicide attempts were cared. The frequency of care between men (n = 73; 50,7%) and women (n = 71; 49,3%) was similar. The women showed younger age (p < 0,001) and used the intoxication method (p < 0,001) twice as often as the men. The presence of mental disorder (p = 0,04) was more common among the men and the time consumed during prehospital care was higher among them, indicating that, possibly, suicide attempts committed by men require greater care for the assistance provided by firefighters. Conclusions: The profile of victims of suicide attempts showed a similar frequency between men and women, with younger women. In women, there was a predominance of intoxications. Besides that, mental disorders were more prevalent. However, it is necessary to early recognition of cases of suicide attempts, the main forms of action and the adequate completion of pre-hospital care forms.

Ansiedade em minorias sexuais e de gênero: uma revisão integrativa / Anxiety in sexual and gender minorities: an integrative review

RESUMO Objetivo Evidenciar os fatores predisponentes relativos à ansiedade em minorias sexuais e de gênero na literatura. Métodos Trata-se de uma revisão integrativa. A busca dos artigos foi realizada em três bases de dados eletrônicas: PubMed/Medline, Scopus e ISI Web of Knowledge . Foram utilizados os descritores " anxiety ", " LGBT people ", " gay ", " bisexual ", " lesbian " e " transgender ", com textos completos, publicados no período de 2013 a 2018, no idioma inglês, e foi usado o operador boleano AND . Resultados Foram encontrados 712 artigos. Cinquenta e oito (58) artigos foram selecionados para serem lidos na íntegra e 13 atenderam aos critérios de inclusão desta revisão. As evidências mostram que a população LGBT apresenta maior risco para transtornos mentais, entre eles a ansiedade, quando comparada aos heterossexuais. O aparecimento dos sinais e sintomas de ansiedade estão relacionados com a vergonha e o comportamento evitativo dessa população devido à forte discriminação e à ausência de apoio social e familiar, o que ocasiona altos níveis de angústia. Apenas dois artigos estudaram menores de 18 anos. Conclusões Os profissionais da saúde devem estar abertos, acolhedores e atentos à saúde mental desse público, visando contribuir com a promoção da saúde, apoio social, familiar e a redução da discriminação.

ABSTRACT Objective To evidence the predisposing factors related to anxiety in sexual and gender minorities in the literature. Methods This is an integrative review. The search of the articles was conducted in three databases: PubMed/Medline, Scopus and ISI Web of Knowledge. The descriptors "anxiety", "LGBT people", "gay", "bisexual", "lesbian" and "transgender" were used, with complete texts, published between 2013 and 2018, in the English language, boolean operator AND was used. Results A total of 712 articles were found. Fifty-eight (58) articles were selected to be read in their entirety and 13 met the inclusion criteria of this review. Evidence shows that LGBT people is at higher risk for mental disorders, including anxiety, when compared to heterosexual. The appearance of signs and symptoms of anxiety are related to shame and the avoidant behavior of this population due to the strong discrimination and lack of social and family life, which causes high levels of distress. Only two articles studied minors 18 years old. Conclusions Health professionals should be welcoming and attentive to health mental health of this public, with a view to contributing to health promotion, social and family support and reduction of discrimination.

Suicide attempts in a emergency hospital.

This study aimed to characterize the profiles of suicide attempts that were attended to in the Hospital of Alagoas in the year 2010. Four hundred sixty-one charts and service bulletins were analyzed. Patients attempting suicide were predominately female. There were significant difference for suicide attempts (SAs) among men and women in the age of 10 to 19 years and 60 to 69 years. Women have tried more suicide aged between 10 and 19 years and men between 60 and 69 years. The ingestion of drugs was the most frequent method for women; and poisoning, use of sharp objects and hanging for men. The results of this study may contribute to elaboration, planning and implementation of preventive measures to reduce cases of SAs.

Genetic Polymorphisms and Generalized Anxiety Disorder: a systematic review / Polimorfismos genéticos e transtornos generalizados de ansiedade

OBJECTIVE: Generalized Anxiety Disorder is a disease characterized by feelings of anxiety, fear, excessive worrying and tension in the face of life experiences. This study aims to identify genetic polymorphisms associated with Generalized Anxiety Disorder described in scientific literature. METHOD: This review was set up by searching PubMed/Medline, Web of Science and Scopus database using the following key words: "gene and generalized anxiety disorder", "SNP and generalized anxiety disorder" and "polymorphism and generalized anxiety disorder". RESULTS: We found ten polymorphic varieties of nine genes that showed association and seven polymorphic varieties of three genes that showed no association with Generalized Anxiety disorder: genes NPY, BDNF, BLC2, DED2, RGS2, HTR1A, MAOA, ERS2 and 5-HTT showed association, whereas BDNF, ERS1 and TPH showed no association with the Disorder. Conflicting results regarding BDNF come from different studies. CONCLUSION: This review identified a variety of genetic polymorphisms, that have been studied in relation to Generalized Anxiety Disorder. Taken jointly, their results are inconclusive, showing that more genetic studies focused on this mental disorder are necessary.

OBJETIVO: O Transtorno de Ansiedade Generalizada (TAG) é uma doença caracterizada por sentimentos de ansiedade, medo, preocupação excessiva e tensão, frente as experiências de vida. Este estudo visa identificar polimorfismos genéticos associados com TAG, descritos na literatura científica. MÉTODO: Esta revisão utilizou o banco de dados PubMed/Medline, Web of Science e Scopus, usando as seguintes palavras-chave: "gene and generalized anxiety disorder", "SNP and generalized anxiety disorder" e "polymorphism and generalized anxiety disorder". RESULTADOS: Encontramos 10 polimorfismos que mostraram associação e 7 polimorfismos que não mostraram associação com TAG. Os genes NPY, BDNF, BLC2, DED2, RGS2, HTR1A, MAOA, ERS2 e 5-HTT mostraram polimorfismos associados ao transtorno. BDNF, ERS1 e TPH não mostraram tais associações. CONCLUSÃO: Esta revisão identificou uma variedade de polimorfismos genéticos, com resultados inconclusivos relativamente ao TAG, mostrando a necessidade de estudos genéticos voltados a este transtorno mental.

Evaluation of the quality of life and risk of suicide

OBJECTIVE: To identify the socio-demographic profiles, suicidal ideation, the presence of mental disorders and the quality of life of patients using mental health services in Arapiraca, Alagoas, Brazil. METHOD: Interviews were conducted in family health units and the Psychosocial Attention Center. The sample included 202 mental disorder patients with a risk of suicide attempts, 207 mental disorder patients without a risk of suicide attempts and 196 controls. This study used an identification questionnaire, the abbreviated World Health Organization Quality of Life questionnaire, Beck‘s Suicidal Ideation Scale and the Mini International Neuropsychiatric Interview. RESULTS: Patients who had a mental disorder and a risk of suicide attempts tended to be single, had less education and lower family income, were not working and showed lower scores in quality of life domains; 73 of these patients had suicidal ideation in the previous week. Depressive disorders, manic episodes, hypomanic episodes, social phobias, obsessive compulsive disorder, post-traumatic stress disorder, psychotic syndromes and generalized anxiety disorder were more frequent and statistically significant for patients at risk for suicide attempts. CONCLUSION: The management of patients with a risk of suicide attempts must focus on individual patients because this risk is directly linked to changes in quality of life and the improvement of these patients’ prognosis.

Suicidal ideation and chronotype assessment in nurses and police officers / Ideação suicida e avaliação de cronotipo em enfermeiras e policiais militares

BACKGROUND: Nurses and police officers are professionals that work in shifts and have jobs that require attention and responsibility. They work under conditions that can cause stress, anxiety and changes in sleep patterns. OBJECTIVE: This study aims to identify symptoms of anxiety and depression, chronotype and the presence of suicidal ideations in nurses and police officers in the city of Arapiraca/Alagoas, Brazil. METHODS: This is a descriptive and quantitative study. The interviews were conducted using (i) identification records and general data, (ii) the Beck Anxiety Inventory, (iii) the Center for Epidemiologic Studies Depression Scale and (iv) the Horne-Östberg Questionnaire. RESULTS: Fifty-three nurses and 111 police officers participated in the research. Nurses and police officers exhibited indifferent to moderate matutinal chronotypes. Most of the nurses and police officers reported minimal to light levels of anxiety. Nurses and police officers presented elevated risk for depression. Five nurses and six police officers had considered attempting suicide at the time of the research. There were no significant differences between the study groups with respect to anxiety and depression symptoms, chronotype and suicidal ideations. CONCLUSION: The nurses and police officers examined presented high risk for symptoms of anxiety and depression; a considerable number of nurses and officers had lifetime suicidal ideations. Implementation of preventive measures is necessary for the early diagnosis of anxiety and depressive disorders in order to prevent complications, including possible suicide.

INTRODUÇÃO: Enfermeiros e policiais militares são profissionais que trabalham em turnos e têm empregos que exigem atenção e responsabilidade. Eles trabalham sob condições que podem causar estresse, ansiedade e mudanças nos padrões de sono. OBJETIVO: Este estudo visa identificar sintomas de ansiedade e depressão, cronotipo e a presença de ideação suicida em enfermeiros e policiais militares de Arapiraca/Alagoas, Brasil. MÉTODO: Este é um estudo descritivo e quantitativo. As entrevistas foram realizadas usando registros de Identificação e Dados Gerais, o Inventário de Ansiedade de Beck, a Escala de Depressão do Centro de Estudos Epidemiológicos e o questionário cronotipo de Horne-Ostberg. RESULTADOS: Cinquenta e três enfermeiras e 111 policiais militares participaram do estudo. Militares e enfermeiras apresentaram cronotipo matutino indiferente e moderado. A maioria das enfermeiras e militares relatou níveis mínimos e leve de ansiedade. As enfermeiras e os policiais militares apresentaram um risco elevado para depressão. Cinco enfermeiras e seis policiais militares pensaram em tantar suicídio até o momento da pesquisa. Não houve diferenças significativas (p > 0,05) entre os grupos de estudo com relação aos sintomas de ansiedade e depressão, cronotipo e ideação suicida. CONCLUSÃO: As enfermeiras e policiais militares estudados apresentaram um alto risco de sintomas de ansiedade e depressão. Um número considerável de enfermeiras e policiais militares tiveram ideação suicida ao longo da vida. A implementação de medidas de prevenção é necessária para o diagnóstico precoce de ansiedade e transtornos depressivos para evitar complicações, dentre estas, o suicídio.

Atendimento a tentativas de suicídio por serviço de atenção pré-hospitalar / Pre-hospital attendance to suicide attempts

Objetivo: Investigar as características das vítimas de tentativa de suicídio atendidas em serviço pré-hospitalar e os intervalos de tempo consumidos nessa fase de atendimento. Métodos: Estudo transversal utilizando dados da fase pré-hospitalar de atendimento às vítimas de tentativa de suicídio no município de Arapiraca, no ano de 2011. Para análise dos dados, foram realizados teste exato de Fisher, teste t de Student e regressão logística múltipla. Resultados: Foram atendidas 80 vítimas de tentativa de suicídio pelo serviço de atenção pré-hospitalar. As mulheres, com idade superior a dos homens, foram as que mais tentaram suicídio (n = 44, 55%), e a intoxicação por medicamentos foi o método mais utilizado (n = 44, 55%). As tentativas de suicídio ocorreram com maior frequência no outono (n = 29, 36,25%), no dia de domingo (n = 18, 22,5%), principalmente no período vespertino (n = 33, 41,25%). O tempo gasto para o atendimento pré-hospitalar variou entre 34,4 e 40,5 minutos. As variáveis que estiveram associadas às tentativas de suicídio por sexo foram idade (p = 0,03) e tempo de transporte (p = 0,01). Conclusão: Foram encontradas diferenças entre os sexos das vítimas de tentativa de suicídio atendidas pelo serviço de atenção pré-hospitalar. As mulheres apresentaram maior idade que os homens e o tempo de transporte foi maior em vítimas do sexo masculino, sugerindo maior gravidade nas tentativas de suicídio cometidas por esse grupo. .

Objective: To investigate the characteristics of the victims of suicide attempts treated in pre-hospital services and the time intervals consumed in this phase of care. Methods: Cross-sectional study, which used data from pre-hospital care to victims of suicide attempts occurred in the town of Arapiraca, in 2011. For data analysis, Fisher’s exact test, Student’s t test and multiple logistic regression were performed. Results: A total of 80 victims of suicide attempts were treated by pre-hospital care service. Women over the age of men were the most attempted suicide victims (n = 44, 55%) and drug intoxication was the most used method (n = 44, 55%). Suicide attempts occurred more frequently in autumn (n = 29, 36.25%), on Sunday (n = 18, 22.5%), mainly in the afternoon (n = 33, 41.25%). The time spent in the pre-hospital care varied between 34.4 and 40.5 minutes. The variables that were associated with suicide attempts by sex were: age (p = 0.03) and the transportation time (p = 0.01). Conclusion: It was found that there were differences between the sexes of the victims of suicide attempts treated by pre-hospital attendance. Women were older than men and the transportation time was higher in male victims, suggesting greater severity in suicide attempts committed by this particular group. .

Suicide attempts in a emergency hospital / Perfil de tentativas de suicidio em um hospital de emergencia

This study aimed to characterize the profiles of suicide attempts that were attended to in the Hospital of Alagoas in the year 2010. Four hundred sixty-one charts and service bulletins were analyzed. Patients attempting suicide were predominately female. There were significant difference for suicide attempts (SAs) among men and women in the age of 10 to 19 years and 60 to 69 years. Women have tried more suicide aged between 10 and 19 years and men between 60 and 69 years. The ingestion of drugs was the most frequent method for women; and poisoning, use of sharp objects and hanging for men. The results of this study may contribute to elaboration, planning and implementation of preventive measures to reduce cases of SAs.

Este estudo teve como objetivo caracterizar o perfil das tentativas de suicídio (TS) que foram atendidos num Hospital de Alagoas, no ano de 2010. Quatrocentos e sessenta e um boletins foram analisados. Houve diferença significativa para as tentativas de suicídio entre homens e mulheres nas faixas etárias de 10 a 19 anos e de 60 a 69 anos. As mulheres cometem mais suicídio na faixa etária entre 10 e 19 anos e os homens entre 60 e 69 anos. A ingestão de drogas foi o método mais frequente para as mulheres; o envenenamento, uso de objetos pontiagudos e enforcamento para homens. Os resultados deste estudo podem contribuir para a elaboração, planejamento e implementação de medidas preventivas em casos de TS.

Associação entre polimorfismos genéticos e transtorno bipolar / Associations between genetic polymorphisms and bipolar disorder

Transtorno bipolar (TB) é uma doença comum que afeta aproximadamente 1% da população. Apresenta características crônicas e agudas graves, com índices de remissão de baixa e alta prevalência de comorbidades clínicas e psiquiátricas. O objetivo do presente artigo é sintetizar dados de vários artigos que investigaram polimorfismos genéticos associados com TB. Dentre os 129 artigos selecionados, identificaram-se 79 (85,87%) genes associados com TB. Essa análise identificou cinco genes que são os mais citados na literatura: CANAC1C, DAOA, TPH2, ANK3 e DISC1. Dos 92 genes identificados nesses artigos, 33 (35,87%) não mostraram associação com TB. Essa análise mostrou que, apesar dos avanços recentes com relação ao papel do polimorfismo genético na predisposição para TB, mais pesquisas ainda são necessárias para elucidar sua influência sobre esse transtorno.

Bipolar disorder (BD) is a common disorder that affects approximately 1% of the population. It is associated with both chronic and acute severe features, such as low remission rates and a high prevalence of clinical and psychiatric comorbidities. The aim of the present article is to synthesize data from various articles that investigated genetic polymorphisms associated with BD. The 129 articles selected identified 79 (85.87%) genes associated with BD. This analysis identified the five genes that are the most cited in the literature: CANAC1C, DAOA, TPH2, ANK3 and DISC1. Of the 92 genes identified in these articles, 33 (35.87%) showed no association with BD. This analysis showed that, despite recent advances with respect to the role of genetic polymorphism in predisposition to BD, further research is still required to elucidate its influence on this disorder.