Detalles de la búsqueda
1.
Transcriptomic analysis of AHR wildtype and Knock-out rat livers supports TCDD's role in AHR/ARNT-mediated circadian disruption and hepatotoxicity.
Toxicol Appl Pharmacol;
487: 116956, 2024 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-38735589
2.
Comparison of Rat Hepatocyte 2D-Monocultures and Hepatocytes Non-Parenchymal Cell Co-Cultures for Assessing Chemical Toxicity.
Int J Toxicol;
42(1): 19-36, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-36523256
3.
NRF2-ARE signaling is responsive to haloacetonitrile-induced oxidative stress in human keratinocytes.
Toxicol Appl Pharmacol;
450: 116163, 2022 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35842135
4.
Integration of paraquat pharmacokinetic data across species using PBPK modelling.
Toxicol Appl Pharmacol;
417: 115462, 2021 04 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33631233
5.
Using quantitative modeling tools to assess pharmacokinetic bias in epidemiological studies showing associations between biomarkers and health outcomes at low exposures.
Environ Res;
197: 111183, 2021 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-33887277
6.
A systematic approach to evaluate plausible modes of actions for mouse lung tumors in mice exposed to 4-methylimidozole.
Regul Toxicol Pharmacol;
124: 104977, 2021 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-34174380
7.
A toxicogenomic approach for the risk assessment of the food contaminant acetamide.
Toxicol Appl Pharmacol;
388: 114872, 2020 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31881176
8.
The role of fit-for-purpose assays within tiered testing approaches: A case study evaluating prioritized estrogen-active compounds in an in vitro human uterotrophic assay.
Toxicol Appl Pharmacol;
387: 114774, 2020 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31783037
9.
Gene co-regulation and co-expression in the aryl hydrocarbon receptor-mediated transcriptional regulatory network in the mouse liver.
Arch Toxicol;
94(1): 113-126, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31728591
10.
Updating physiologically based pharmacokinetic models for manganese by incorporating rapid association/dissociation processes in tissues.
Toxicol Appl Pharmacol;
372: 1-10, 2019 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30978397
11.
Incorporation of in vitro metabolism data and physiologically based pharmacokinetic modeling in a risk assessment for chloroprene.
Inhal Toxicol;
31(13-14): 468-483, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31992090
12.
Considerations for refining the risk assessment process for formaldehyde: Results from an interdisciplinary workshop.
Regul Toxicol Pharmacol;
106: 210-223, 2019 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-31059732
13.
Adipocyte-specific deficiency of Nfe2l1 disrupts plasticity of white adipose tissues and metabolic homeostasis in mice.
Biochem Biophys Res Commun;
503(1): 264-270, 2018 09 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-29935181
14.
Physiologically-based pharmacokinetic modeling suggests similar bioavailability of Mn from diet and drinking water.
Toxicol Appl Pharmacol;
359: 70-81, 2018 11 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30243844
15.
Based on an analysis of mode of action, styrene-induced mouse lung tumors are not a human cancer concern.
Regul Toxicol Pharmacol;
95: 17-28, 2018 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-29496518
16.
Strain-related differences in mouse lung gene expression over a two-year period of inhalation exposure to styrene: Relevance to human risk assessment.
Regul Toxicol Pharmacol;
96: 153-166, 2018 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-29777725
17.
Assessing molecular initiating events (MIEs), key events (KEs) and modulating factors (MFs) for styrene responses in mouse lungs using whole genome gene expression profiling following 1-day and multi-week exposures.
Toxicol Appl Pharmacol;
335: 28-40, 2017 11 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28951217
18.
A tissue dose-based comparative exposure assessment of manganese using physiologically based pharmacokinetic modeling-The importance of homeostatic control for an essential metal.
Toxicol Appl Pharmacol;
322: 27-40, 2017 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28237878
19.
Combining transcriptomics and PBPK modeling indicates a primary role of hypoxia and altered circadian signaling in dichloromethane carcinogenicity in mouse lung and liver.
Toxicol Appl Pharmacol;
332: 149-158, 2017 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28392392
20.
Multiple receptors shape the estrogen response pathway and are critical considerations for the future of in vitro-based risk assessment efforts.
Crit Rev Toxicol;
47(7): 564-580, 2017 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-28675057