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1.

FAN1 modifies Huntington's disease progression by stabilizing the expanded HTT CAG repeat.

Goold, Robert; Flower, Michael; Moss, Davina Hensman; Medway, Chris; Wood-Kaczmar, Alison; Andre, Ralph; Farshim, Pamela; Bates, Gill P; Holmans, Peter; Jones, Lesley; Tabrizi, Sarah J.

Hum Mol Genet; 28(4): 650-661, 2019 02 15.

Artículo en Inglés | MEDLINE | ID: mdl-30358836

2.

Human Huntington's disease pluripotent stem cell-derived microglia develop normally but are abnormally hyper-reactive and release elevated levels of reactive oxygen species.

O'Regan, Grace C; Farag, Sahar H; Casey, Caroline S; Wood-Kaczmar, Alison; Pocock, Jennifer M; Tabrizi, Sarah J; Andre, Ralph.

J Neuroinflammation; 18(1): 94, 2021 Apr 19.

Artículo en Inglés | MEDLINE | ID: mdl-33874957

3.

Expression of mutant exon 1 huntingtin fragments in human neural stem cells and neurons causes inclusion formation and mitochondrial dysfunction.

Ghosh, Rhia; Wood-Kaczmar, Alison; Dobson, Lucianne; Smith, Edward J; Sirinathsinghji, Eva C; Kriston-Vizi, Janos; Hargreaves, Iain P; Heaton, Robert; Herrmann, Frank; Abramov, Andrey Y; Lam, Amanda J; Heales, Simon J; Ketteler, Robin; Bates, Gillian P; Andre, Ralph; Tabrizi, Sarah J.

FASEB J; 34(6): 8139-8154, 2020 06.

Artículo en Inglés | MEDLINE | ID: mdl-32329133

4.

RNA-Seq of Huntington's disease patient myeloid cells reveals innate transcriptional dysregulation associated with proinflammatory pathway activation.

Miller, James R C; Lo, Kitty K; Andre, Ralph; Hensman Moss, Davina J; Träger, Ulrike; Stone, Timothy C; Jones, Lesley; Holmans, Peter; Plagnol, Vincent; Tabrizi, Sarah J.

Hum Mol Genet; 25(14): 2893-2904, 2016 07 15.

Artículo en Inglés | MEDLINE | ID: mdl-27170315

5.

Prion-mediated neurodegeneration is associated with early impairment of the ubiquitin-proteasome system.

McKinnon, Chris; Goold, Rob; Andre, Ralph; Devoy, Anny; Ortega, Zaira; Moonga, Julie; Linehan, Jacqueline M; Brandner, Sebastian; Lucas, José J; Collinge, John; Tabrizi, Sarah J.

Acta Neuropathol; 131(3): 411-25, 2016 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-26646779

6.

Characterisation of immune cell function in fragment and full-length Huntington's disease mouse models.

Träger, Ulrike; Andre, Ralph; Magnusson-Lind, Anna; Miller, James R C; Connolly, Colúm; Weiss, Andreas; Grueninger, Stephan; Silajdzic, Edina; Smith, Donna L; Leavitt, Blair R; Bates, Gillian P; Björkqvist, Maria; Tabrizi, Sarah J.

Neurobiol Dis; 73: 388-98, 2015 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-25447230

7.

Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry.

Deriziotis, Pelagia; André, Ralph; Smith, David M; Goold, Rob; Kinghorn, Kerri J; Kristiansen, Mark; Nathan, James A; Rosenzweig, Rina; Krutauz, Dasha; Glickman, Michael H; Collinge, John; Goldberg, Alfred L; Tabrizi, Sarah J.

EMBO J; 30(15): 3065-77, 2011 Jul 08.

Artículo en Inglés | MEDLINE | ID: mdl-21743439

8.

An exploratory double-blind, randomized clinical trial with selisistat, a SirT1 inhibitor, in patients with Huntington's disease.

Süssmuth, Sigurd D; Haider, Salman; Landwehrmeyer, G Bernhard; Farmer, Ruth; Frost, Chris; Tripepi, Giovanna; Andersen, Claus A; Di Bacco, Marco; Lamanna, Claudia; Diodato, Enrica; Massai, Luisa; Diamanti, Daniela; Mori, Elisa; Magnoni, Letizia; Dreyhaupt, Jens; Schiefele, Karin; Craufurd, David; Saft, Carsten; Rudzinska, Monika; Ryglewicz, Danuta; Orth, Michael; Brzozy, Sebastian; Baran, Anna; Pollio, Giuseppe; Andre, Ralph; Tabrizi, Sarah J; Darpo, Borje; Westerberg, Goran.

Br J Clin Pharmacol; 79(3): 465-76, 2015 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-25223731

9.

HTT-lowering reverses Huntington's disease immune dysfunction caused by NFκB pathway dysregulation.

Träger, Ulrike; Andre, Ralph; Lahiri, Nayana; Magnusson-Lind, Anna; Weiss, Andreas; Grueninger, Stephan; McKinnon, Chris; Sirinathsinghji, Eva; Kahlon, Shira; Pfister, Edith L; Moser, Roger; Hummerich, Holger; Antoniou, Michael; Bates, Gillian P; Luthi-Carter, Ruth; Lowdell, Mark W; Björkqvist, Maria; Ostroff, Gary R; Aronin, Neil; Tabrizi, Sarah J.

Brain; 137(Pt 3): 819-33, 2014 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-24459107

10.

Development of an ELISA assay for the quantification of soluble huntingtin in human blood cells.

Massai, Luisa; Petricca, Lara; Magnoni, Letizia; Rovetini, Luca; Haider, Salman; Andre, Ralph; Tabrizi, Sarah J; Süssmuth, Sigurd D; Landwehrmeyer, Bernhard G; Caricasole, Andrea; Pollio, Giuseppe; Bernocco, Simonetta.

BMC Biochem; 14: 34, 2013 Nov 25.

Artículo en Inglés | MEDLINE | ID: mdl-24274906

11.

Mislocalization of Nucleocytoplasmic Transport Proteins in Human Huntington's Disease PSC-Derived Striatal Neurons.

Lange, Jenny; Wood-Kaczmar, Alison; Ali, Aneesa; Farag, Sahar; Ghosh, Rhia; Parker, Jennifer; Casey, Caroline; Uno, Yumiko; Kunugi, Akiyoshi; Ferretti, Patrizia; Andre, Ralph; Tabrizi, Sarah J.

Front Cell Neurosci; 15: 742763, 2021.

Artículo en Inglés | MEDLINE | ID: mdl-34658796

12.

Wild-type huntingtin regulates human macrophage function.

O'Regan, Grace C; Farag, Sahar H; Ostroff, Gary R; Tabrizi, Sarah J; Andre, Ralph.

Sci Rep; 10(1): 17269, 2020 10 14.

Artículo en Inglés | MEDLINE | ID: mdl-33057179

13.

Inhibition of tumour necrosis factor alpha in the R6/2 mouse model of Huntington's disease by etanercept treatment.

Pido-Lopez, Jeffrey; Tanudjojo, Benedict; Farag, Sahar; Bondulich, Marie-Katrin; Andre, Ralph; Tabrizi, Sarah J; Bates, Gillian P.

Sci Rep; 9(1): 7202, 2019 05 10.

Artículo en Inglés | MEDLINE | ID: mdl-31076648

14.

Huntington's disease: fighting on many fronts.

Andre, Ralph; Wild, Edward J; Tabrizi, Sarah J.

Brain; 135(Pt 4): 998-1001, 2012 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-22427330

15.

In vivo neutralization of the protagonist role of macrophages during the chronic inflammatory stage of Huntington's disease.

Pido-Lopez, Jeffrey; Andre, Ralph; Benjamin, Agnesska C; Ali, Nadira; Farag, Sahar; Tabrizi, Sarah J; Bates, Gillian P.

Sci Rep; 8(1): 11447, 2018 07 30.

Artículo en Inglés | MEDLINE | ID: mdl-30061661

16.

Structural imaging in premanifest and manifest Huntington disease.

Scahill, Rachael I; Andre, Ralph; Tabrizi, Sarah J; Aylward, Elizabeth H.

Handb Clin Neurol; 144: 247-261, 2017.

Artículo en Inglés | MEDLINE | ID: mdl-28947121

17.

Allele-Selective Suppression of Mutant Huntingtin in Primary Human Blood Cells.

Miller, James R C; Pfister, Edith L; Liu, Wanzhao; Andre, Ralph; Träger, Ulrike; Kennington, Lori A; Lo, Kimberly; Dijkstra, Sipke; Macdonald, Douglas; Ostroff, Gary; Aronin, Neil; Tabrizi, Sarah J.

Sci Rep; 7: 46740, 2017 04 24.

Artículo en Inglés | MEDLINE | ID: mdl-28436437

18.

Disruption of immune cell function by mutant huntingtin in Huntington's disease pathogenesis.

Andre, Ralph; Carty, Lucy; Tabrizi, Sarah J.

Curr Opin Pharmacol; 26: 33-8, 2016 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-26461267

19.

Differential actions of IL-1 alpha and IL-1 beta in glial cells share common IL-1 signalling pathways.

Andre, Ralph; Pinteaux, Emmanuel; Kimber, Ian; Rothwell, Nancy J.

Neuroreport; 16(2): 153-7, 2005 Feb 08.

Artículo en Inglés | MEDLINE | ID: mdl-15671867

20.

Mutant Huntingtin Does Not Affect the Intrinsic Phenotype of Human Huntington's Disease T Lymphocytes.

Miller, James R C; Träger, Ulrike; Andre, Ralph; Tabrizi, Sarah J.

PLoS One; 10(11): e0141793, 2015.

Artículo en Inglés | MEDLINE | ID: mdl-26529236

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