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1.
J Child Psychol Psychiatry ; 59(6): 676-683, 2018 06.
Artículo en Inglés | MEDLINE | ID: mdl-29197109

RESUMEN

BACKGROUND: The developmental propensity model of antisocial behavior posits that several dispositional characteristics of children transact with the environment to influence the likelihood of learning antisocial behavior across development. Specifically, greater dispositional negative emotionality, greater daring, and lower prosociality-operationally, the inverse of callousness- and lower cognitive abilities are each predicted to increase risk for developing antisocial behavior. METHODS: Prospective tests of key predictions derived from the model were conducted in a high-risk sample of 499 twins who were assessed on dispositions at 10-17 years of age and assessed for antisocial personality disorder (APD) symptoms at 22-31 years of age. Predictions were tested separately for parent and youth informants on the dispositions using multiple regressions that adjusted for oversampling, nonresponse, and clustering within twin pairs, controlling demographic factors and time since the first assessment. RESULTS: Consistent with predictions, greater numbers of APD symptoms in adulthood were independently predicted over a 10-15 year span by higher youth ratings on negative emotionality and daring and lower youth ratings on prosociality, and by parent ratings of greater negative emotionality and lower prosociality. A measure of working memory did not predict APD symptoms. CONCLUSIONS: These findings support future research on the role of these dispositions in the development of antisocial behavior.


Asunto(s)
Conducta Infantil/fisiología , Trastorno de la Conducta/fisiopatología , Desarrollo Humano/fisiología , Trastorno de la Conducta Social/fisiopatología , Conducta Social , Adolescente , Adulto , Trastorno de Personalidad Antisocial/fisiopatología , Niño , Femenino , Humanos , Masculino , Modelos Teóricos , Estudios Prospectivos , Tennessee , Adulto Joven
2.
J Am Coll Health ; 71(9): 2730-2739, 2023 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-34985410

RESUMEN

STUDY PURPOSE: This study was undertaken to establish if the Holistic Wellness Assessment (HWA) can detect intra-individual changes following a 12-week undergraduate course in holistic wellness (N = 235). METHODS: A single-group pretest post-test non-experimental design was used to evaluate changes in the eight HWA factors; concurrent collection of demographic variables enabled a limited moderation analysis. RESULTS: Dependent t-tests adjusted for a false discovery rate revealed significant changes in six of the eight HWA factors indicating curriculum sensitivity in these HWA factors. CONCLUSIONS: Interpretations are offered at the HWA factor level that discuss relationships between curriculum activities and student artifacts with changes in factor and item responses over time. Using the HWA as a pre/post-test instrument helps instructors and students evaluate the changes that have been made as a result of the curriculum.


Asunto(s)
Estudiantes de Medicina , Estudiantes , Humanos , Universidades , Recolección de Datos , Curriculum
3.
Neuroimage ; 60(4): 1982-91, 2012 May 01.
Artículo en Inglés | MEDLINE | ID: mdl-22348884

RESUMEN

Functional neuroimaging often generates large amounts of data on regions of interest. Such data can be addressed effectively with a widely-used statistical technique based on measurement theory that has not yet been applied to neuroimaging. Confirmatory factor analysis is a convenient hypothesis-driven modeling environment that can be used to conduct formal statistical tests comparing alternative hypotheses regarding the elements of putative neuronal networks. In such models, measures of each activated region of interest are treated as indicators of an underlying latent construct that represents the contemporaneous activation of the elements in the network. As such, confirmatory factor analysis focuses analyses on the activation of hypothesized networks as a whole, improves statistical power by modeling measurement error, and provides a theory-based approach to data reduction with a robust statistical basis. This approach is illustrated using data on seven regions of interest in a hypothesized mesocorticostriatal reward system in a sample of 262 adult volunteers assessed during a card-guessing reward task. A latent construct reflecting contemporaneous activation of the reward system was found to be significantly associated with a latent construct measuring impulsivity, particularly in males.


Asunto(s)
Mapeo Encefálico/métodos , Análisis Factorial , Interpretación de Imagen Asistida por Computador/métodos , Imagen por Resonancia Magnética , Modelos Teóricos , Adolescente , Adulto , Encéfalo/fisiología , Femenino , Humanos , Masculino , Adulto Joven
4.
Prosthet Orthot Int ; 46(2): 140-147, 2022 Apr 01.
Artículo en Inglés | MEDLINE | ID: mdl-35019885

RESUMEN

BACKGROUND: This study determined the differences in 2-Minute Walk Test (2MWT) distances between people with lower limb amputations in clinical and research settings and described variations in test administration in various clinical settings. STUDY DESIGN: Retrospective Cross-sectional design. METHODS: The 2MWT for 290 patients with lower limb amputations were obtained from a medium-sized prosthetic company with locations within the central United States. Data on 12 prosthetists' 2MWT administration decisions were obtained from the results of an administrative questionnaire. Patient 2MWT distances were compared with published distances. Multiple regression was used to examine the impact of test settings on 2MWT outcomes. Descriptive statistics were used to present prosthetists' variations in test administration. RESULTS: Clinical 2MWT distances were significantly less than distances obtained in a research setting. Clinical facilities reported inconsistent path dimensions and potential obstacles in proximity to the test area. Variations in test administration by prosthetists with respect to path length, instructions, turn marker, and overage measurement may contribute to the differences. CONCLUSIONS: Prosthetists should be aware that comparisons of patients' 2MWT distance in a clinical environment may differ from published results. Although variations in clinical environments are usually nonmodifiable characteristics of the clinical facility, test administration and scoring could be modified.


Asunto(s)
Miembros Artificiales , Instituciones de Atención Ambulatoria , Amputación Quirúrgica , Estudios Transversales , Humanos , Extremidad Inferior/cirugía , Estudios Retrospectivos , Estados Unidos , Prueba de Paso , Caminata
5.
J Psychiatr Res ; 152: 187-193, 2022 08.
Artículo en Inglés | MEDLINE | ID: mdl-35752070

RESUMEN

A polygenic risk score (PRS) for attention-deficit/hyperactivity disorder (ADHD) has been found to be associated with ADHD in multiple studies, but also with many other dimensions of problems. Little is known, however, about the processes underlying these transdiagnostic associations. Using data from the baseline and 1-year follow-up assessments of 9- to 10-year-old children in the Adolescent Brain Cognitive Development™ (ABCD©) Study, associations were assessed between an ADHD PRS and both general and specific factors of psychological problems defined in bifactor modeling. Additionally, prospective mediated paths were tested from the ADHD PRS to dimensions of problems in the follow-up assessment through baseline measures of executive functioning (EF) and two facets of impulsivity: lower perseverance and greater impulsiveness in the presence of surgent positive emotions. Previous findings of modest but significant direct associations of the ADHD PRS with the general factor of psychological problems were replicated in both assessments in 4,483 children of European ancestry. In addition, significant statistical mediation was found from the ADHD PRS to the general factor, specific ADHD, and conduct problems in the follow-up assessment through each of the two facets of impulsivity. In contrast, EF did not statistically mediate associations between the ADHD PRS and psychological problems. These results suggest that polygenic risk transdiagnostically influences both psychological problems and facets of impulsivity, perhaps partly through indirect pathways via facets of impulsivity.


Asunto(s)
Trastorno por Déficit de Atención con Hiperactividad , Adolescente , Trastorno por Déficit de Atención con Hiperactividad/diagnóstico , Niño , Función Ejecutiva , Humanos , Conducta Impulsiva , Herencia Multifactorial , Estudios Prospectivos
6.
Artículo en Inglés | MEDLINE | ID: mdl-33518499

RESUMEN

BACKGROUND: Executive functions (EFs) are important partly because they are associated with risk for psychopathology and substance use problems. Because EFs have been linked to white matter microstructure, we tested the prediction that fractional anisotropy (FA) and mean diffusivity (MD) in white matter tracts are associated with EFs and dimensions of psychopathology in children younger than the age of widespread psychoactive substance use. METHODS: Parent symptom ratings, EF test scores, and diffusion tensor parameters from 8588 9- to 10-year-olds in the ABCD Study (Adolescent Brain Cognitive Development Study) were used. RESULTS: A latent factor derived from EF test scores was significantly associated with specific conduct problems and attention-deficit/hyperactivity disorder problems, with dimensions defined in a bifactor model. Furthermore, EFs were associated with FA and MD in 16 of 17 bilateral white matter tracts (range: ß = .05; SE = .17; through ß = -.31; SE = .06). Neither FA nor MD was directly associated with psychopathology, but there were significant indirect associations via EFs of both FA (range: ß = .01; SE = .01; through ß = -.09; SE = .02) and MD (range: ß = .01; SE = .01; through ß = .09; SE = .02) with both specific conduct problems and attention-deficit/hyperactivity disorder in all tracts except the forceps minor. CONCLUSIONS: EFs in children are inversely associated with diffusion tensor imaging measures in nearly all tracts throughout the brain. Furthermore, variance in diffusion tensor measures that is shared with EFs is indirectly shared with attention-deficit/hyperactivity disorder and conduct problems.


Asunto(s)
Trastorno por Déficit de Atención con Hiperactividad , Sustancia Blanca , Adolescente , Trastorno por Déficit de Atención con Hiperactividad/patología , Encéfalo/patología , Niño , Imagen de Difusión Tensora/métodos , Función Ejecutiva , Humanos , Individualidad , Sustancia Blanca/diagnóstico por imagen , Sustancia Blanca/patología
7.
Res Child Adolesc Psychopathol ; 49(10): 1275-1288, 2021 10.
Artículo en Inglés | MEDLINE | ID: mdl-33871795

RESUMEN

Substantial evidence implicates the amygdala and related structures in the processing of negative emotions. Furthermore, neuroimaging evidence suggests that variations in amygdala volumes are related to trait-like individual differences in neuroticism/negative emotionality, although many questions remain about the nature of such associations. We conducted planned tests of the directional prediction that dispositional negative emotionality measured at 10-17 years using parent and youth ratings on the Child and Adolescent Dispositions Scale (CADS) would predict larger volumes of the amygdala in adulthood and conducted exploratory tests of associations with other regions implicated in emotion processing. Participants were 433 twins strategically selected for neuroimaging during wave 2 from wave 1 of the Tennessee Twins Study (TTS) by oversampling on internalizing and/or externalizing psychopathology risk. Controlling for age, sex, race-ethnicity, handedness, scanner, and total brain volume, youth-rated negative emotionality positively predicted bilateral amygdala volumes after correction for multiple testing. Each unit difference of one standard deviation (SD) in negative emotionality was associated with a .12 SD unit difference in larger volumes of both amygdalae. Parent-rated negative emotionality predicted greater thickness of the left caudal/dorsal anterior cingulate cortex (ß = 0.28). Associations of brain structure with negative emotionality were not moderated by sex. These results are striking because dispositions assessed at 10-17 years of age were predictive of grey matter volumes measured 12-13 years later in adulthood. Future longitudinal studies should examine the timing of amygdala/cingulate associations with dispositional negative emotionality to determine when these associations emerge during development.


Asunto(s)
Amígdala del Cerebelo , Giro del Cíngulo , Adolescente , Adulto , Amígdala del Cerebelo/diagnóstico por imagen , Encéfalo , Niño , Emociones , Giro del Cíngulo/diagnóstico por imagen , Humanos , Personalidad
8.
J Clin Child Adolesc Psychol ; 39(3): 351-61, 2010.
Artículo en Inglés | MEDLINE | ID: mdl-20419576

RESUMEN

Lahey and Waldman (2003, 2005) proposed a model in which three dispositions-sympathetic response to others; negative emotional response to threat, frustration, and loss; and positive response to novelty and risk-transact with the environment to influence risk for conduct disorder (CD). To test this model, the Child and Adolescent Dispositions Scale (CADS) was developed to measure these dispositions using parent ratings of the child. Here we report psychometric evaluations of a parallel youth self-report version (CADS-Y). Exploratory factor analysis of CADS-Y items among 832 9- to 17-year-olds yielded a 3-factor structure that was consistent with the model and invariant across sex and informants. In 1,582 pairs of 9- to 17-year-old twins, confirmatory factor analyses supported the CADS-Y 3-factor model. Each CADS-Y dimension was associated with CD and related personality dimensions as predicted.


Asunto(s)
Trastorno de la Conducta/diagnóstico , Miedo/psicología , Frustación , Modelos Psicológicos , Encuestas y Cuestionarios/normas , Adolescente , Niño , Trastorno de la Conducta/psicología , Análisis Factorial , Femenino , Humanos , Masculino , Padres , Psicometría , Reproducibilidad de los Resultados , Factores de Riesgo , Factores Sexuales , Medio Social
9.
Mil Med ; 185(Suppl 1): 480-489, 2020 01 07.
Artículo en Inglés | MEDLINE | ID: mdl-32074320

RESUMEN

INTRODUCTION: The objective was to determine if the Mobile Device Outcomes-based Rehabilitation Program (MDORP) improved strength, mobility, and gait quality in service members (SMs) and Veterans with lower limb amputation (LLA). METHODS: Seven SMs and 10 Veterans with LLA enrolled and were trained to use a mobile sensor system, called Rehabilitative Lower Limb Orthopedic Analysis Device (ReLOAD). ReLOAD provided participants with real-time assessment of gait deviations, subsequent corrective audio feedback, and exercise prescription for normalizing gait at home and in the community. After baseline testing, prosthetic gait and exercise training, participants took ReLOAD home and completed an 8-week walking and home exercise program. Home visits were conducted every 2 weeks to review gait training and home exercises. RESULTS: Significant improvements in hip extensor strength, basic and high-level mobility, musculoskeletal endurance, and gait quality (P < 0.05) were found at the completion of the 8-week intervention. CONCLUSION: Preliminary MDORP results are promising in its ability to improve basic and high-level mobility, lower limb strength, and gait quality in a group of SMs and Veterans with LLA. In addition, "booster" prosthetic training may be justified in an effort helps maintain an active lifestyle, promotes prosthetic use, and mitigates secondary health effects.


Asunto(s)
Amputación Quirúrgica/normas , Amputados/rehabilitación , Teléfono Inteligente/instrumentación , Adulto , Anciano , Amputación Quirúrgica/rehabilitación , Amputados/estadística & datos numéricos , Estudios Transversales , Femenino , Marcha/fisiología , Humanos , Masculino , Persona de Mediana Edad , Equilibrio Postural/fisiología , Rehabilitación/métodos , Rehabilitación/normas , Rehabilitación/estadística & datos numéricos , Teléfono Inteligente/tendencias , Resultado del Tratamiento , Estados Unidos , United States Department of Defense/organización & administración , United States Department of Defense/estadística & datos numéricos , United States Department of Veterans Affairs/organización & administración , United States Department of Veterans Affairs/estadística & datos numéricos
10.
Personal Neurosci ; 3: e5, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32524066

RESUMEN

Predictive associations were estimated between socioemotional dispositions measured at 10-17 years using the Child and Adolescent Dispositions Scale (CADS) and future individual differences in white matter microstructure measured at 22-31 years of age. Participants were 410 twins (48.3% monozygotic) selected for later neuroimaging by oversampling on risk for psychopathology from a representative sample of child and adolescent twins. Controlling for demographic covariates and total intracranial volume (TICV), each CADS disposition (negative emotionality, prosociality, and daring) rated by one of the informants (parent or youth) significantly predicted global fractional anisotropy (FA) averaged across the major white matter tracts in brain in adulthood, but did so through significant interactions with sex after false discovery rate (FDR) correction. In females, each 1 SD difference in greater parent-rated prosociality was associated with 0.43 SD greater FA (p < 0.0008). In males, each 1 SD difference in greater parent-rated daring was associated with 0.24 SD lower FA (p < 0.0008), and each 1 SD difference in greater youth-rated negative emotionality was associated with 0.18 SD greater average FA (p < 0.0040). These findings suggest that CADS dispositions are associated with FA, but associations differ by sex. Exploratory analyses suggest that FA may mediate the associations between dispositions and psychopathology in some cases. These associations over 12 years could reflect enduring brain-behavior associations in spite of transactions with the environment, but could equally reflect processes in which dispositional differences in behavior influence the development of white matter. Future longitudinal studies are needed to resolve the causal nature of these sex-moderated associations.

11.
J Abnorm Psychol ; 129(7): 677-688, 2020 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-32672986

RESUMEN

[Correction Notice: An Erratum for this article was reported in Vol 129(7) of Journal of Abnormal Psychology (see record 2020-72912-001). In the article (http://dx.doi.org/10.1037/abn0000601), an acknowledgment is missing from the author note. The missing acknowledgement is included in the erratum.] Psychopathology can be viewed as a hierarchy of correlated dimensions. Many studies have supported this conceptualization, but they have used alternative statistical models with differing interpretations. In bifactor models, every symptom loads on both the general factor and 1 specific factor (e.g., internalizing), which partitions the total explained variance in each symptom between these orthogonal factors. In second-order models, symptoms load on one of several correlated lower-order factors. These lower-order factors load on a second-order general factor, which is defined by the variance shared by the lower-order factors. Thus, the factors in second-order models are not orthogonal. Choosing between these valid statistical models depends on the hypothesis being tested. Because bifactor models define orthogonal phenotypes with distinct sources of variance, they are optimal for studies of shared and unique associations of the dimensions of psychopathology with external variables putatively relevant to etiology and mechanisms. Concerns have been raised, however, about the reliability of the orthogonal specific factors in bifactor models. We evaluated this concern using parent symptom ratings of 9-10 year olds in the ABCD Study. Psychometric indices indicated that all factors in both bifactor and second-order models exhibited at least adequate construct reliability and estimated replicability. The factors defined in bifactor and second-order models were highly to moderately correlated across models, but have different interpretations. All factors in both models demonstrated significant associations with external criterion variables of theoretical and clinical importance, but the interpretation of such associations in second-order models was ambiguous due to shared variance among factors. (PsycInfo Database Record (c) 2020 APA, all rights reserved).


Asunto(s)
Trastornos Mentales/clasificación , Modelos Estadísticos , Niño , Análisis Factorial , Femenino , Humanos , Masculino , Psicometría , Psicopatología , Reproducibilidad de los Resultados
12.
J Abnorm Psychol ; 129(7): 759, 2020 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-33001697

RESUMEN

Reports an error in "Criterion validity and relationships between alternative hierarchical dimensional models of general and specific psychopathology" by Tyler M. Moore, Antonia N. Kaczkurkin, E. Leighton Durham, Hee Jung Jeong, Malerie G. McDowell, Randolph M. Dupont, Brooks Applegate, Jennifer L. Tackett, Carlos Cardenas-Iniguez, Omid Kardan, Gaby N. Akcelik, Andrew J. Stier, Monica D. Rosenberg, Donald Hedeker, Marc G. Berman and Benjamin B. Lahey (Journal of Abnormal Psychology, Advanced Online Publication, Jul 16, 2020, np). In the article (http://dx.doi.org/10.1037/abn0000601), an acknowledgment is missing from the author note. The missing acknowledgement is included in the erratum. (The following abstract of the original article appeared in record 2020-50590-001.) Psychopathology can be viewed as a hierarchy of correlated dimensions. Many studies have supported this conceptualization, but they have used alternative statistical models with differing interpretations. In bifactor models, every symptom loads on both the general factor and 1 specific factor (e.g., internalizing), which partitions the total explained variance in each symptom between these orthogonal factors. In second-order models, symptoms load on one of several correlated lower-order factors. These lower-order factors load on a second-order general factor, which is defined by the variance shared by the lower-order factors. Thus, the factors in second-order models are not orthogonal. Choosing between these valid statistical models depends on the hypothesis being tested. Because bifactor models define orthogonal phenotypes with distinct sources of variance, they are optimal for studies of shared and unique associations of the dimensions of psychopathology with external variables putatively relevant to etiology and mechanisms. Concerns have been raised, however, about the reliability of the orthogonal specific factors in bifactor models. We evaluated this concern using parent symptom ratings of 9-10 year olds in the ABCD Study. Psychometric indices indicated that all factors in both bifactor and second-order models exhibited at least adequate construct reliability and estimated replicability. The factors defined in bifactor and second-order models were highly to moderately correlated across models, but have different interpretations. All factors in both models demonstrated significant associations with external criterion variables of theoretical and clinical importance, but the interpretation of such associations in second-order models was ambiguous due to shared variance among factors. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

13.
Prosthet Orthot Int ; 43(1): 80-87, 2019 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-30095355

RESUMEN

BACKGROUND:: Prosthetic socket fit is an important element associated with successful ambulation and use of a prosthesis. Prosthetists and rehabilitation clinicians would benefit from an assessment tool that discriminates between and quantifies the multiple determinants that influence the lower limb amputee's performance and satisfaction of a prosthetic socket. OBJECTIVES:: To determine the internal consistency of the comprehensive lower limb amputee socket survey, a new self-report measure of prosthetic socket satisfaction that quantifies suspension, stability, comfort, and appearance. STUDY DESIGN:: Cross-sectional sample of active amputees. METHODS:: Interviews were conducted with prosthetists, physical therapists, and lower limb amputees to identify clinical concerns and common activities influencing socket fit. An expert panel of five clinicians reviewed the items and constructed the original version of the comprehensive lower limb amputee socket survey which was then administered to a convenience sample of 47 active lower limb amputees. Item analysis and Cronbach's alpha were used to determine the final version of the comprehensive lower limb amputee socket survey. RESULTS:: Following item raw score-to-total score correlation with Cronbach's alpha for comprehensive lower limb amputee socket survey determinants, internal consistency improved when nine questions were eliminated. CONCLUSION:: The comprehensive lower limb amputee socket survey is a self-report measure of prosthetic socket satisfaction with very good internal consistency. CLINICAL RELEVANCE: When socket problems occur, the ability to determine the specific cause can reduce modification time, enhance socket fit, and promote patient satisfaction. A standardized multi-dimensional assessment measure of socket satisfaction enables prosthetists to quantify the multiple determinants of socket satisfaction, improve patient communication, and demonstrate the value of socket interventions.


Asunto(s)
Amputados/rehabilitación , Miembros Artificiales , Satisfacción del Paciente/estadística & datos numéricos , Diseño de Prótesis/métodos , Autoinforme , Adulto , Amputación Quirúrgica/métodos , Estudios Transversales , Femenino , Humanos , Extremidad Inferior/cirugía , Masculino , Dimensión del Dolor , Comodidad del Paciente/estadística & datos numéricos , Ajuste de Prótesis/métodos , Calidad de Vida , Caminata/fisiología
14.
J Abnorm Psychol ; 128(6): 574-584, 2019 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-31259570

RESUMEN

We previously hypothesized that the ubiquitous, but patterned correlations among all dimensions of psychopathology reflect a hierarchy of progressively more nonspecific causal influences, with a general factor of psychopathology-also dubbed the p factor-reflecting the most transdiagnostic causal influences. We further hypothesized that the general factor is a manifestation of individual differences in 1 or more trait-like dispositions, particularly negative emotionality, that are nonspecifically associated with risk for essentially every dimension of psychopathology. We tested the hypothesis that this and other dispositions measured in childhood/adolescence significantly predict general and specific second-order dimensions of psychopathology in early adulthood. The latent general factor of psychopathology itself was correlated over time from 10-17 to 23-31 years of age even though it was defined by different informants and different dimensions of symptoms. Using a measure of dispositions that minimizes item contamination with psychopathology symptoms, parent-rated negative emotionality in childhood and adolescence predicted the general factor of psychopathology based on self-reported symptoms in early adulthood, whereas parent-rated daring predicted the specific adult externalizing psychopathology factor after correction for multiple tests. In addition, youth-rated negative emotionality and daring predicted specific adult externalizing psychopathology. These results over a span of 12 years suggests that the general factor is relatively stable over time and that associations of dispositional traits with second-order dimensions of psychopathology are enduring, sometimes across informants. (PsycINFO Database Record (c) 2019 APA, all rights reserved).


Asunto(s)
Emociones/fisiología , Trastornos Mentales/fisiopatología , Personalidad/fisiología , Conducta Social , Adolescente , Niño , Análisis Factorial , Femenino , Humanos , Masculino , Estudios Prospectivos
15.
Neuroimage Clin ; 22: 101705, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-30753960

RESUMEN

Increasing data indicate that prevalent forms of psychopathology can be organized into second-order dimensions based on their correlations, including a general factor of psychopathology that explains the common variance among all disorders and specific second-order externalizing and internalizing factors. Nevertheless, most existing studies on the neural correlates of psychopathology employ case-control designs that treat diagnoses as independent categories, ignoring the highly correlated nature of psychopathology. Thus, for instance, although perturbations in white matter microstructure have been identified across a range of mental disorders, nearly all such studies used case-control designs, leaving it unclear whether observed relations reflect disorder-specific characteristics or transdiagnostic associations. Using a representative sample of 410 young adult twins oversampled for psychopathology risk, we tested the hypothesis that some previously observed relations between white matter microstructure properties in major tracts and specific disorders are related to second-order factors of psychopathology. We examined fractional anisotropy (FA), radial diffusivity (RD), and axial diffusivity (AD). White matter correlates of all second-order factors were identified after controlling for multiple statistical tests, including the general factor (FA in the body of the corpus callosum), specific internalizing (AD in the fornix), and specific externalizing (AD in the splenium of the corpus callosum, sagittal stratum, anterior corona radiata, and internal capsule). These findings suggest that some features of white matter within specific tracts may be transdiagnostically associated multiple forms of psychopathology through second-order factors of psychopathology rather with than individual mental disorders.


Asunto(s)
Trastorno de Personalidad Antisocial/patología , Encéfalo/patología , Sustancia Blanca/patología , Adulto , Imagen de Difusión Tensora/métodos , Femenino , Humanos , Masculino , Adulto Joven
16.
J Abnorm Child Psychol ; 36(2): 187-206, 2008 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-17912624

RESUMEN

Confirmatory factor analyses were conducted of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) symptoms of common mental disorders derived from structured interviews of a representative sample of 4,049 twin children and adolescents and their adult caretakers. A dimensional model based on the assignment of symptoms to syndromes in DSM-IV fit better than alternative models, but some dimensions were highly correlated. Modest sex and age differences in factor loadings and correlations were found that suggest that the dimensions of psychopathology are stable across sex and age, but slightly more differentiated at older ages and in males. The dimensions of symptoms were found to be hierarchically organized within higher-order "externalizing" and "internalizing" dimensions, which accounted for much of their variance. Major depression and generalized anxiety disorder were substantially correlated with both the "externalizing" dimension and the "internalizing" dimension, however, suggesting the need to reconceptualize the nature of these higher-order dimensions.


Asunto(s)
Manual Diagnóstico y Estadístico de los Trastornos Mentales , Trastornos Mentales/diagnóstico , Modelos Estadísticos , Psicología del Adolescente/estadística & datos numéricos , Psicología Infantil/estadística & datos numéricos , Adolescente , Distribución por Edad , Cuidadores/psicología , Niño , Análisis Factorial , Femenino , Humanos , Control Interno-Externo , Entrevista Psicológica/métodos , Masculino , Trastornos Mentales/clasificación , Trastornos Mentales/psicología , Distribución por Sexo , Tennessee
17.
J Clin Child Adolesc Psychol ; 37(4): 794-807, 2008 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-18991130

RESUMEN

Lahey and Waldman proposed a developmental propensity model in which three dimensions of children's emotional dispositions are hypothesized to transact with the environment to influence risk for conduct disorder, heterogeneity in conduct disorder, and comorbidity with other disorders. To prepare for future tests of this model, a new measure of these dispositions was tested. Exploratory factor analysis of potential items was conducted in a sample of 1,358 participants 4 to 17 years of age. Confirmatory factor analyses then confirmed the three dispositional dimensions in a second sample of 2,063 pairs of 6- to 17-year-old twins. Caretaker ratings of the dispositional dimensions were associated as predicted with symptoms of conduct disorder and other psychopathology. In a third sample, caretaker ratings of each disposition correlated uniquely with relevant observational measures of child behavior and unintentional injuries. These findings provide initial support for the new dispositional measure.


Asunto(s)
Trastorno por Déficit de Atención con Hiperactividad/diagnóstico , Carácter , Trastorno de la Conducta/diagnóstico , Enfermedades en Gemelos/diagnóstico , Emociones , Medio Social , Adolescente , Trastorno por Déficit de Atención con Hiperactividad/genética , Trastorno por Déficit de Atención con Hiperactividad/psicología , Niño , Preescolar , Trastorno de la Conducta/genética , Trastorno de la Conducta/psicología , Conducta Cooperativa , Enfermedades en Gemelos/genética , Enfermedades en Gemelos/psicología , Empatía , Femenino , Humanos , Masculino , Relaciones Madre-Hijo , Psicometría/estadística & datos numéricos , Reproducibilidad de los Resultados , Asunción de Riesgos , Socialización
18.
Artículo en Inglés | MEDLINE | ID: mdl-28990308

RESUMEN

There is evidence that models of psychopathology specifying a general factor and specific second-order factors fit better than competing structural models. Nonetheless, additional tests are needed to examine the generality and boundaries of the general factor model. In a selected second wave of a cohort study, first-order dimensions of psychopathology symptoms in 499 23- to 31-year-old twins were analyzed. Using confirmatory factor analysis, a bifactor model specifying a general factor and specific internalizing and externalizing factors fit better than competing models. Factor loadings in this model were sex invariant despite greater variances in the specific internalizing factor among females and greater variances in the general and specific externalizing factors among males. The bifactor structure was robust to the exclusion of any single first-order dimension of psychopathology. Furthermore, the results were essentially unchanged when all overlapping symptoms that define multiple disorders were excluded from symptom dimensions. Furthermore, the best-fitting bifactor model also emerged in exploratory structural equation modeling with freely estimated cross-loadings. The general factor of psychopathology was robust across variations in measurement and analysis.


Asunto(s)
Análisis Factorial , Trastornos Mentales/clasificación , Trastornos Mentales/fisiopatología , Modelos Estadísticos , Adulto , Estudios de Cohortes , Femenino , Humanos , Masculino , Adulto Joven
19.
Front Hum Neurosci ; 12: 127, 2018.
Artículo en Inglés | MEDLINE | ID: mdl-29706875

RESUMEN

Go/no-go tasks are widely used to index cognitive control. This construct has been linked to white matter microstructure in a circuit connecting the right inferior frontal gyrus (IFG), subthalamic nucleus (STN), and pre-supplementary motor area. However, the specificity of this association has not been tested. A general factor of white matter has been identified that is related to processing speed. Given the strong processing speed component in successful performance on the go/no-go task, this general factor could contribute to task performance, but the general factor has often not been accounted for in past studies of cognitive control. Further, studies on cognitive control have generally employed small unrepresentative case-control designs. The present study examined the relationship between go/no-go performance and white matter microstructure in a large community sample of 378 subjects that included participants with a range of both clinical and subclinical nonpsychotic psychopathology. We found that white matter microstructure properties in the right IFG-STN tract significantly predicted task performance, and remained significant after controlling for dimensional psychopathology. The general factor of white matter only reached statistical significance when controlling for dimensional psychopathology. Although the IFG-STN and general factor tracts were highly correlated, when both were included in the model, only the IFG-STN remained a significant predictor of performance. Overall, these findings suggest that while a general factor of white matter can be identified in a young community sample, white matter microstructure properties in the right IFG-STN tract show a specific relationship to cognitive control. The findings highlight the importance of examining both specific and general correlates of cognition, especially in tasks with a speeded component.

20.
Health Educ Behav ; 34(5): 735-47, 2007 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-17287492

RESUMEN

Obesity is a growing global concern. Examining dietary habits of individuals can facilitate the development of important prevention approaches, which are needed to decrease the incidence of obesity and other related diseases and improve quality of life indices. Because food preferences and dietary habits vary across cultures, it is essential that prevention programs are based on specific populations. Using both ethnographic and quantitative methods, food-consumption patterns were investigated among 1,125 children in the Commonwealth of the Northern Mariana Islands. Differences were observed related to food frequency, age of children, and grade level. Exploratory factor analyses suggested that the individual foods were best organized into food-consumption groups that reflected cultural characteristics rather than more commonly referenced food organizational systems. In addition to developmental differences in food consumption patterns, results suggest that the ethnicity of parents may play a role in the diet of children.


Asunto(s)
Características Culturales , Dieta/etnología , Etnicidad , Adolescente , Antropología Cultural , Niño , Familia , Femenino , Humanos , Masculino , Psicometría , Factores Socioeconómicos
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