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PURPOSE: To evaluate changes in the peripheral refraction (PR), visual quality, and accommodative lag with a novel soft radial refractive gradient (SRRG) experimental contact lens that produces peripheral myopic defocus. METHODS: 59 myopic right eyes were fitted with the lens. The PR was measured up to 30° in the nasal and temporal horizontal visual fields and compared with values obtained without the lens. The accommodative lag was measured monocularly using the distance-induced condition method at 40 cm, and the higher-order aberrations (HOAs) of the entire eye were obtained for 3- and 5-mm pupils by aberrometry. Visual performance was assessed through contrast sensitivity function (CSF). RESULTS: With the lens, the relative PR became significantly less hyperopic from 30° to 15° temporally and 30° nasally in the M and J0 refractive components (P<0.05). Cylinder foci showed significant myopization from 30° to 15° temporally and 30° to 25° nasally (P<0.05). The HOAs increased significantly, the CSF decreased slightly but reached statistical significance for 6 and 12 cycles per degree (P<0.05), and the accommodative lag decreased significantly with the SRRG lens (P=0.0001). There was a moderate correlation between HOAs and CSF at medium and high spatial frequencies. CONCLUSION: The SRRG lens induced a significant change in PR, particularly in the temporal retina. Tangential and sagittal foci changed significantly in the peripheral nasal and temporal retina. The decreased accommodative lag and increased HOAs particularly in coma-like aberration may positively affect myopia control. A longitudinal study is needed to confirm this potential.
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Acomodación Ocular/fisiología , Lentes de Contacto Hidrofílicos , Miopía/rehabilitación , Refracción Ocular/fisiología , Campos Visuales/fisiología , Adolescente , Adulto , Sensibilidad de Contraste/fisiología , Femenino , Humanos , Estudios Longitudinales , Masculino , Miopía/fisiopatología , Agudeza Visual/fisiología , Adulto JovenRESUMEN
The strong wavelength dependency of diffractive elements casts reasonable doubts on the reliability of near-infrared- (NIR)-based clinical instruments, such as aberrometers and double-pass systems, for assessing, post-surgery, the visual quality of eyes implanted with diffractive multifocal intraocular lenses (DMIOLs). The results obtained for such patients when using NIR light can be misleading. Ordinary compensation for the refractive error bound to chromatic aberration is not enough because it only considers the best focus shift but does not take into account the distribution of light energy among the foci which strongly depends on the wavelength-dependent energy efficiency of the diffractive orders used in the DMIOL design. In this paper, we consider three commercial DMIOL designs with the far focus falling within the range of (-1, 0, +1)-diffractive orders. We prove theoretically the differences existing in the physical performance of the studied lenses when using either the design wavelength in the visible spectrum or a NIR wavelength (780 to 850 nm). Based on numerical simulation and on-bench experimental results, we show that such differences cannot be neglected and may affect all the foci of a DMIOL, including the far focus.
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BACKGROUND: This study aims to detect alterations in the spatio-chromatic pseudophakic vision produced by multifocal diffractive intraocular lenses (IOLs) and provides a physical interpretation. METHODS: In vitro characterization of the imaging performance of two diffractive IOLs: AT LISA Tri (Zeiss) and FineVision (PhysIOL) in on-bench model eye illuminated with red (R, 625 nm), green (G, 530 nm) and blue (B, 455 nm) lights. We used the metrics: energy efficiency (EE), area under the modulation transfer function, longitudinal chromatic aberration (LCA), and halo intensity. Through-focus (TF) analysis and calculation of the expected defocus curve under white (W) daylight were included. In vivo visual acuity (VA) of 50 pseudophakics (60 eyes) was assessed under W, R, G, B lights at far and near. Two clinical experiments evaluated LCA and R, G, B TF-EE effects on pseudophakic vision and their relative importance. RESULTS: Clinical mean VA values under W light agreed with the predicted values at far and near for both IOLs. LCA measurements and R, G, B TF-EE curves were consistent with their lens design based on the 0th and 1st diffraction orders operative for far and near vision, respectively. LCA effects were compensated at near but noticed at far (- 0.75 D under B light). We detected strong asymmetry in visual resolution depending on the object distance and the illuminating wavelength-red predominance at far, blue predominance at near-in consistency with the TF-EE measurements. CONCLUSIONS: Diffractive multifocal IOL designs produce asymmetries in the spatio-chromatic vision of pseudophakics beyond the alterations strictly due to LCA. VA asymmetry for far/near object distance under R and B illumination is clinically detectable in subjects implanted with IOLs with 0th and 1st diffraction orders for far and near vision, respectively. Such VA asymmetry cannot be explained solely from the influence of defocus, as would be derived from a chromatic difference of power, but mainly from the wavelength dependence of the EE.
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PURPOSE: To assess the optical performance of four extended range of vision (ERV) intraocular lenses (IOLs) and predict the visual quality of the average pseudophakic patient. METHODS: Four ERV IOLs (LuxSmart, Bausch & Lomb; Vivity, Alcon Laboratories, Inc; Tecnis Eyhance, Johnson & Johnson Vision; and Isopure, PhysIOL) were inserted in an on-bench model eye. Their performance was assessed using through-focus modulation transfer function (MTF)-based metrics, through-focus point spread function, and halo analysis for three pupils (2.0, 3.0, and 4.5 mm). The expected visual acuity and the range of vision was estimated from the through-focus area under the MTF curve. A monofocal IOL (Tecnis ZCB00; Johnson & Johnson Vision) was included as reference. RESULTS: The Tecnis ZCB00 showed the highest image quality at far for all pupil conditions, closely followed by the Tecnis Eyhance. The LuxSmart and Vivity performed similarly in the intermediate range (-1.00 to -2.00 diopters [D]) with a 3.0-mm pupil and showed better performance than the other ERV IOLs for that range. All ERV lenses presented pupil dependent performance. All lenses reached normal expected visual acuity (0.0 logMAR) at far distance. The Tecnis ZCB00, Tecnis Eyhance, and Isopure decreased their expected visual acuity with defocus (0.1 logMAR at 66 cm) faster than the LuxSmart and Vivity (0.0 logMAR at 66 cm). The LuxSmart and Vivity produced greater halos than the Tecnis ZCB00, but they showed little change with larger pupils. The Isopure lens showed a pupil-dependent halo. CONCLUSIONS: The expected visual acuity decreased with the object distance differently, depending on the ERV design. The Vivity and LuxSmart lenses showed an expanded imaging capability (⩾ 0.50 D) with respect to a monofocal lens that may benefit intermediate vision. The Tecnis Eyhance and Isopure lenses showed more modest extensions that mainly rely on pupil constriction. [J Refract Surg. 2022;38(11):688-697.].
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Lentes Intraoculares , Facoemulsificación , Humanos , Sensibilidad de Contraste , Agudeza Visual , Visión Ocular , Pupila , Diseño de PrótesisRESUMEN
This article studies the relationship between two metrics, the area under the modulation transfer function (MTFa) and the energy efficiency (EE), and their ability to predict the visual quality of patients implanted with multifocal intraocular lenses (IOLs). The optical quality of IOLs is assessed in vitro using two metrics, the MTFa and EE. We measured them for three different multifocal IOLs with parabolic phase profile using image formation, through-focus (TF) scanning, three R, G, B wavelengths, and two pupils. We analyzed the correlation between MTFa and EE. In parallel, clinical defocus curves of visual acuity (VA) were measured and averaged from sets of patients implanted with the same IOLs. An excellent linear correlation was found between the MTFa and EE for the considered IOLs, wavelengths and pupils (R2 > 0.9). We computed the polychromatic TF-MTFa, TF-EE, and derived mathematical relationships between each metrics and clinical average VA. MTFa and EE proved to be equivalent metrics to characterize the optical quality of the studied multifocal IOLs and also in terms of clinical VA predictability.
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OBJECTIVE: To evaluate the degree of axial elongation with soft radial refractive gradient (SRRG) contact lenses, orthokeratology (OK), and single vision (SV) spectacle lenses (control) during a period of 1 year before treatment and 2 years after treatment. METHODS: This was a prospective, longitudinal, nonrandomized study. The study groups consisted of 30, 29, and 41 children, respectively. The axial length (AL) was measured during 2 years after recruitment and lens fitting. RESULTS: The baseline refractive sphere was correlated significantly (Spearman's Rho (ρ) correlation = 0.542; P < 0.0001) with the amount of myopia progression before baseline. After 2 years, the mean myopia progression values for the SRRG, OK, and SV groups were -0.56 ± 0.51, -0.32 ± 0.53, and -0.98 ± 0.58 diopter, respectively. The results represent reductions in myopic progression of 43% and 67% for the SRRG and OK groups, respectively, compared to the SV group. The AL increased 27% and 38% less in the SRRG and OK groups, respectively compared with the SV group at the 2-year visit (P < 0.05). Axial elongation was not significantly different between SRRG and OK (P = 0.430). CONCLUSION: The SRRG lens significantly decreased AL elongation compared to the SV control group. The SRRG lens was similarly effective to OK in preventing myopia progression in myopic children and adolescent.