Factors predicting postoperative range of motion for anatomic total shoulder arthroplasty.

BACKGROUND: Total shoulder arthroplasty (TSA) has repeatedly been shown to be an effective and durable treatment option for end-stage arthritis with good long-term survivorship. Whereas pain relief is typically the primary goal, improvements in range of motion are typically expected as well. The factors that influence postoperative motion have not been well characterized. The purpose of the study was to examine the factors that influence ultimate postoperative motion after TSA. METHODS: A retrospective review was conducted of prospectively collected data of 230 patients with minimum 1-year follow-up after TSA for end-stage arthropathy with an intact rotator cuff. Analysis was focused on factors that may correlate with postoperative measured forward flexion, abduction, external rotation, and internal rotation. Included in this analysis was perception of motion, age, body mass index (BMI), comorbidities (smoking, diabetes, osteoporosis, hypercholesterolemia, inflammatory arthritis, and thyroid disease), and number of comorbidities. RESULTS: Preoperative motion in all directions was predictive of postoperative motion for forward flexion (R = 0.235; P < .001), abduction (R = 0.363; P < .001), external rotation (R = 0.325; P < .001), and internal rotation (R = 0.213; P = .002). BMI and diabetes both negatively correlated with internal rotation (R = -0.134, P = .40 and R = -0.196, P = .003, respectively). Individual and total number of comorbidities were not predictive of postoperative motion. The patient's perception of preoperative motion also did not correlate with postoperative motion. CONCLUSIONS: Preoperative range of motion before TSA is most predictive of final motion achieved. Individual and total number of comorbidities are not predictive of postoperative motion. Patients with high diabetes and increased BMI have limited postoperative internal rotation.

Renal Denervation for Resistant Hypertension in the contemporary era: A Systematic Review and Meta-analysis.

Renal denervation (RDN) is a catheter-based ablation procedure designed to treat resistant hypertension (RH). The objective of our study is to determine the effect of RDN on blood pressure and renal function in patients with RH in comparison to medical therapy alone. We performed an extensive literature search for randomized control trials (RCT) reporting office and 24 hr. blood pressure changes and estimated glomerular filtration rate (eGFR) at baseline and 6 months. We calculated a weighted standardized mean difference of blood pressure and renal outcomes between RDN and control groups using random effects models. Our search yielded 608 studies of which we included 15 studies for the final analysis. A total of 857 patients were treated with RDN and 616 patients treated with medical therapy ± sham procedure. Only 5 studies were double-blinded RCT with sham control. The adjusted standardized mean difference in the change in office based systolic and diastolic pressures (p = 0.18; p = 0.14); 24 hr. systolic and diastolic pressures (p = 0.20; p = 0.18); and eGFR (p = 0.20) from baseline to 6 months is statistically insignificant with significant heterogeneity. Subgroup analysis showed that among sham controlled trials, 24 hr. systolic blood pressure showed a modest but statistically significant benefit favoring renal denervation in patients with RH. Our meta-analysis of 15 RCTs showed no significant benefit of RDN on blood pressure control in patients with resistant hypertension. Subgroup analysis of sham control studies showed a modest benefit in 24 hr. systolic blood pressure at 6 months with RDN.