Detalles de la búsqueda
1.
Clofazimine pKa Determination by Potentiometry and Spectrophotometry: Reverse Cosolvent Dependence as an Indicator of the Presence of Dimers in Aqueous Solutions.
Mol Pharm;
20(6): 3160-3169, 2023 06 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37096898
2.
Nortriptyline Hydrochloride Solubility-pH Profiles in a Saline Phosphate Buffer: Drug-Phosphate Complexes and Multiple pHmax Domains with a Gibbs Phase Rule "Soft" Constraints.
Mol Pharm;
19(2): 710-719, 2022 02 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-35050628
3.
Disproportionation of Pharmaceutical Salts: pHmax and Phase-Solubility/pH Variance.
Mol Pharm;
18(7): 2724-2743, 2021 07 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-34142831
4.
Ionizable Drug Self-Associations and the Solubility Dependence on pH: Detection of Aggregates in Saturated Solutions Using Mass Spectrometry (ESI-Q-TOF-MS/MS).
Mol Pharm;
18(6): 2311-2321, 2021 06 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-33983741
5.
"Flexible-Acceptor" General Solubility Equation for beyond Rule of 5 Drugs.
Mol Pharm;
17(10): 3930-3940, 2020 10 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-32787270
6.
Findings of the Second Challenge to Predict Aqueous Solubility.
J Chem Inf Model;
60(10): 4791-4803, 2020 10 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-32794744
7.
Solubility Challenge Revisited after Ten Years, with Multilab Shake-Flask Data, Using Tight (SD â¼ 0.17 log) and Loose (SD â¼ 0.62 log) Test Sets.
J Chem Inf Model;
59(6): 3036-3040, 2019 06 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-31042031
8.
Cocrystal Solubility Product Prediction Using an in combo Model and Simulations to Improve Design of Experiments.
Pharm Res;
35(2): 40, 2018 Feb 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-29396647
9.
Closed-Loop Doluisio (Colon, Small Intestine) and Single-Pass Intestinal Perfusion (Colon, Jejunum) in Rat-Biophysical Model and Predictions Based on Caco-2.
Pharm Res;
35(1): 2, 2017 12 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-29288412
10.
Passive lipoidal diffusion and carrier-mediated cell uptake are both important mechanisms of membrane permeation in drug disposition.
Mol Pharm;
11(6): 1727-38, 2014 Jun 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-24724562
11.
A comparison of USP 2 and µDISS Profiler™ apparatus for studying dissolution phenomena of ibuprofen and its salts.
Eur J Pharm Sci;
193: 106684, 2024 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-38154507
12.
Mechanistically transparent models for predicting aqueous solubility of rigid, slightly flexible, and very flexible drugs (MW<2000) Accuracy near that of random forest regression.
ADMET DMPK;
11(3): 317-330, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-37829322
13.
Anomalous salting-out, self-association and pKa effects in the practically-insoluble bromothymol blue.
ADMET DMPK;
11(3): 419-432, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-37829325
14.
Predicting Solubility of Newly-Approved Drugs (2016-2020) with a Simple ABSOLV and GSE(Flexible-Acceptor) Consensus Model Outperforming Random Forest Regression.
J Solution Chem;
51(9): 1020-1055, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-35153342
15.
Salt Solubility and Disproportionation - Uses and Limitations of Equations for pHmax and the In-silico Prediction of pHmax.
J Pharm Sci;
111(1): 225-246, 2022 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34863819
16.
Is equilibrium slurry pH a good surrogate for solid surface pH during drug dissolution?
Eur J Pharm Sci;
168: 106037, 2022 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34637897
17.
Integration of In Silico, In Vitro and In Situ Tools for the Preformulation and Characterization of a Novel Cardio-Neuroprotective Compound during the Early Stages of Drug Development.
Pharmaceutics;
14(1)2022 Jan 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-35057075
18.
Understanding the pH Dependence of Supersaturation State-A Case Study of Telmisartan.
Pharmaceutics;
14(8)2022 Aug 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36015261
19.
A new in situ brain perfusion flow correction method for lipophilic drugs based on the pH-dependent Crone-Renkin equation.
Pharm Res;
28(3): 517-30, 2011 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-21042838
20.
Physicochemical selectivity of the BBB microenvironment governing passive diffusion--matching with a porcine brain lipid extract artificial membrane permeability model.
Pharm Res;
28(2): 337-63, 2011 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-20945153