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Silver nanoparticles (AgNP) are among the most widely commercialized nanomaterials globally, with applications in medicine and the food industry. Consequently, the increased use of AgNP in the food industry has led to an unavoidable rise in human exposure to these nanoparticles. Their widespread use raises concerns about potential hazards to human health, specifically their intestinal pro-inflammatory effects. Thus, the main objective of this study was to evaluate the biological effects of two subacute doses of 5 nm polyvinylpyrrolidone (PVP)-AgNP in C57BL/6J mice. One mg/kg body weight or 10 mg/kg bw was provided once a day for 14 days, using a new technology (HaPILLness) that allows voluntary, stress-free, and accurate oral dosing. It was observed that after oral ingestion, while AgNP is biodistributed throughout the entire organism, most of the ingested dose is excreted in the feces. The passage and accumulation of AgNP throughout the intestine instigated a prominent inflammatory response, marked by significant histological, vascular, and cellular transformations. This response was driven by the activation of the nuclear factor-кB (NF-кB) inflammatory pathway, ultimately leading to the generation of multiple cytokines and chemokines.
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Nanopartículas del Metal , Ratones , Humanos , Animales , Ratones Endogámicos C57BL , Nanopartículas del Metal/toxicidad , Plata/toxicidad , Distribución Tisular , IntestinosRESUMEN
Zacca, R, Azevedo, R, Chainok, P, Vilas-Boas, JP, Castro, FAdS, Pyne, DB, and Fernandes, RJ. Monitoring age-group swimmers over a training macrocycle: energetics, technique, and anthropometrics. J Strength Cond Res 34(3): 818-827, 2020-The aim of this study was to quantify changes and contributions of energetic, technique, and anthropometric profiles across the first training macrocycle (16-week) in a traditional 3-peak swimming season. Twenty-four age-group swimmers (10 boys and 14 girls age 14.4 ± 0.9 years) of equal maturational stage were monitored through a 400-m test in front crawl (T400). Energetic, technique, and anthropometric characteristics were compared before (experimental testing 1, E1) and after the preparatory (E2), specific (E3), and competitive (E4) training periods. Sex interaction was not significant for any variable. Multiple linear regressions and principal component analysis were used to identify the most influential variables and the relative contribution of each domain (energetics, technique, and anthropometrics) to changes in swimming performance of T400. The relative contributions for performance of T400 at E1, E2, E3, and E4 were 15, 12, 6, and 13% for energetics, 78, 85, 75, and 70% for technique, and 7, 3, 19 and 17% for anthropometrics, respectively. Technique played the main role during the first 16-week macrocycle in a competitive season, regardless of small fluctuations in the influence of energetics and anthropometrics. Changes and influence of energetics, technique, and anthropometric on age-group swimmers' performance could be described by the T400 swimming test, providing a comprehensive biophysical overview of the main contributors to swimming performance.
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Antropometría , Rendimiento Atlético/fisiología , Natación/fisiología , Adolescente , Factores de Edad , Femenino , Humanos , Modelos Lineales , Masculino , Estudios ProspectivosRESUMEN
Zacca, R, Azevedo, R, Ramos, VR, Abraldes, JA, Vilas-Boas, JP, Castro, FAdS, Pyne, DB, and Fernandes, RJ. Biophysical follow-up of age-group swimmers during a traditional three-peak preparation program. J Strength Cond Res 34(9): 2585-2595, 2020-The aim of this study was to quantify changes and contributions of bioenergetic, technique, and anthropometric profiles across a traditional 3-peak swimming season. Twenty-four age-group swimmers (11 boys: 15 years 6 months ± 1 year 1 month; 13 girls: 14 years 5 months ± 10 months) of equal maturational stage were monitored through a 400-m test in front crawl (T400). Bioenergetic, technique, and anthropometric characteristics were compared before and after macrocycles I, II and III. Sex interaction was verified only for amplitude of the fast oxygen uptake component and height (moderate). Multiple linear regressions and principal component analysis were used to identify the most influential variables and the relative contribution of each domain (bioenergetics, technique, and anthropometrics) to changes in swimming performance of T400. The relative contributions for the performance of T400 after macrocycles I, II, and III were, respectively, 6, 18, and 27% for bioenergetics, 88, 69, and 54% for technique, and 6, 13, and 20% for anthropometrics. Technique was the biggest contributor (71%) for changes in the performance of T400 over the training season, followed by bioenergetics (17%) and anthropometrics (12%). Technique played the main role during the competitive season, regardless of gradual increase in the contribution of bioenergetics and anthropometrics. Despite that, bioenergetics and technique are closely connected, thus a powerful and endurable metabolic base and cannot be overlooked. Changes and contribution of bioenergetics, technique, and anthropometrics on age-group swimmers' performance over a traditional 3-peak swimming season could be described by the T400 swimming test, providing a comprehensive biophysical overview of the main contributors to swimming performance.
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Rendimiento Atlético/fisiología , Metabolismo Energético/fisiología , Natación/fisiología , Adolescente , Antropometría , Femenino , Humanos , Modelos Lineales , Masculino , Consumo de Oxígeno/fisiología , Estudios Prospectivos , Factores SexualesRESUMEN
Changes in performance, energetics and kinematics during age-group swimmers off-season inform the prescription of training for the following season. Age-group swimmers (n = 15, age 14.3 ± 0.7 years) of equal maturational stage performed a 400-m front crawl (T400) before and after a four-weeks training cessation period. Performance-related energetic and kinematic variables were obtained controlling for anthropometric changes and non-swimming specific physical activities during off-season. T400 time decreased 3.8% (95%CI 1.4 to 6.1%; p < 0.01; d = 0.90) with non-specific physical activities (1814 ± 1989 MET-min·wk-1) accounting for ~40% of the underlying variance (p = 0.01; η2 = 0.40). Stroke rate and stroke index decreased despite similar stroke length and index of coordination values. Although mean response time, amplitude, maximal oxygen uptake, heart rate, total energy expenditure, metabolic power and energy cost were similar, aerobic contribution decreased by ~1.8% (-2.7 to -0.9%; p < 0.01; d = -1.19) and anaerobic lactic contribution increased by ~1.6% (0.8 to 2.5%; p < 0.01; d = 1.08) over the off-season. Impaired performance was mainly associated with a decreased stroke rate (r = -0.85 to -0.61; p ≤ 0.02), increased peak blood lactate (r = -0.52; p = 0.05) and fewer non-swimming specific physical activities performed during the off-season (r = -0.58; p = 0.03). The end-of-season cessation of training yielded moderate impairments in age-group swimmers performance-related energetic and kinematic factors, however non-specific physical activities can minimise fitness losses.
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Rendimiento Atlético/fisiología , Acondicionamiento Físico Humano , Aptitud Física , Natación/fisiología , Adolescente , Antropometría , Fenómenos Biomecánicos , Conducta Competitiva/fisiología , Metabolismo Energético , Femenino , Frecuencia Cardíaca , Humanos , Ácido Láctico/sangre , Estudios Longitudinales , Masculino , Consumo de Oxígeno , Maduración Sexual , Factores de TiempoRESUMEN
Zacca, R, Azevedo, R, Peterson Silveira, R, Vilas-Boas, JP, Pyne, DB, Castro, FAdS, and Fernandes, RJ. Comparison of incremental intermittent and time trial testing in age-group swimmers. J Strength Cond Res 33(3): 801-810, 2019-The aim of this study was to compare physiological and biomechanical characteristics between an incremental intermittent test and a time trial protocol in age-group swimmers. Eleven national level age-group swimmers (6 men and 5 women) performed a 7 × 200-m incremental intermittent protocol (until exhaustion; 30-second rest) and a 400-m test (T400) in front crawl on separate days. Cardiorespiratory variables were measured continuously using a telemetric portable gas analyzer. Swimming speed, stroke rate, stroke length, and stroke index were assessed by video analysis. Physiological (oxygen uptake, heart rate, and lactate concentrations) and biomechanical variables between seventh 200-m step (in which the minimal swimming speed that elicits maximal oxygen uptake-vV[Combining Dot Above]O2max was identified) and T400 (time trial/fixed distance) were compared with a paired student's t test, Pearson's product-moment correlation, Passing-Bablok regression, and Bland-Altman plot analyses. There were high level of agreement and high correlations (r-values â¼0.90; p ≤ 0.05) for all physiological variables between the seventh 200-m step and T400. Similarly, there were high level of agreements and high correlations (r-values â¼0.90; p ≤ 0.05) for all biomechanical variables and only trivial bias in swimming speed (0.03 m·s; 2%). Primary physiological and biomechanical responses between incremental intermittent and representative time trial protocols were similar, but best practice dictates protocols should not be used interchangeably to minimize errors in prescribing swimming training speeds. The T400 is a valid, useful, and easier to administer test for aerobic power assessment in age-group swimmers.
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Rendimiento Atlético/fisiología , Fatiga Muscular/fisiología , Natación/fisiología , Adolescente , Fenómenos Biomecánicos , Prueba de Esfuerzo , Femenino , Frecuencia Cardíaca/fisiología , Humanos , Ácido Láctico/sangre , Masculino , Consumo de Oxígeno/fisiología , Descanso/fisiologíaRESUMEN
Introduction: In orthodontics, patients' esthetic expectations involve the final esthetic result as well as the treatment's appliance choice. Personality traits can influence patients' perception, treatment modality selection, expectations, compliance, and satisfaction with the treatment outcome, although there are very few studies on this interconnection between personality and orthodontic appliances. Objective: The aim of this study is to evaluate the relationship between personality traits and the esthetic perception of different orthodontic appliances. Materials and Methods: The online questionnaire is composed of three parts: (1) sociodemographic variables; (2) questions on the esthetic perception of different orthodontic appliances; (3) general personality assessment via the NEO-FFI. A total of 461 questionnaires were accepted. Results: There were statistically significant differences between laypeople and professionals related to assessing smiles and the need for orthodontic treatment. Laypeople identified a statistically significant relationship between personality traits and orthodontic appliances, in which esthetic perception is associated with high traits of agreeableness and openness. Neuroticism is most associated with orthodontic treatment with fixed appliances, which are the most conventional. Conclusions: Professionals tend to have a more critical judgment than laypeople as far as esthetics is concerned. Personality traits play an important role in esthetic perception and may influence orthodontic treatment.
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The digital era is opening countless possibilities in "Sport Sciences"; "Public, Environmental, and Occupational Health"; and "Physical Therapy, Sports Therapy, and Rehabilitation" areas [...].
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Controlling root movement is one of the greatest challenges in orthodontic treatment with aligners, like Invisalign® aligners. Cone Beam Computed Tomography (CBCT) integration into ClinCheck®, enabling bone and root visualisation, allows a more accurate follow-up of the teeth position. This study aims to compare torque measurements of the upper central incisors with and without CBCT and relate them to the upper incisor inclination and facial biotype. In a sample of 70 teeth, torque measurements were obtained by importing images into AutoCAD® software (version 2024). The angle between the tooth's long axis with CBCT duplicate and the tooth's long axis without CBCT was obtained to assess the difference. Statistically significant differences between torque measurements with and without CBCT were found, as well as between these measurements and the inclination of the upper incisors. No statistically significant differences were found among the facial biotypes. The average values of 27.8° ± 3.4° and 21.5° ± 3.2° were obtained for the angle between the axes. Torque without CBCT was lower than torque with CBCT, for the same tooth. The angle between the axes had a similar mean for both teeth. CBCT integration into ClinCheck® allows for a more correct torque measurement.
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Firefighters' occupational activity causes cancer, and the characterization of exposure during firefighting activities remains limited. This work characterizes, for the first time, firefighters' exposure to (coarse/fine/ultrafine) particulate matter (PM) bound polycyclic aromatic hydrocarbons (PAHs) and metal(loid)s during prescribed fires, Fire 1 and Fire 2 (210 min). An impactor collected 14 PM fractions, the PM levels were determined by gravimetry, and the PM-bound PAHs and metal(loid)s were determined by chromatographic and spectroscopic methodologies, respectively. Firefighters were exposed to a total PM level of 1408.3 and 342.5 µg/m3 in Fire 1 and Fire 2, respectively; fine/ultrafine PM represented more than 90% of total PM. Total PM-bound PAHs (3260.2 ng/m3 in Fire 1; 412.1 ng/m3 in Fire 2) and metal(loid)s (660.8 ng/m3 versus 262.2 ng/m3), distributed between fine/ultrafine PM, contained 4.57-24.5% and 11.7-12.6% of (possible/probable) carcinogenic PAHs and metal(loid)s, respectively. Firefighters' exposure to PM, PAHs, and metal(loid)s were below available occupational limits. The estimated carcinogenic risks associated with the inhalation of PM-bound PAHs (3.78 × 10-9 - 1.74 × 10-6) and metal(loid)s (1.50 × 10-2 - 2.37 × 10-2) were, respectively, below and 150-237 times higher than the acceptable risk level defined by the USEPA during 210 min of firefighting activity and assuming a 40-year career as a firefighter. Additional studies need to (1) explore exposure to (coarse/fine/ultrafine) PM, (2) assess health risks, (3) identify intervention needs, and (4) support regulatory agencies recommending mitigation procedures to reduce the impact of fire effluents on firefighters.
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Introduction: This study investigates the effects of social isolation on mental health and cognitive functions in Sprague Dawley (SD) and Wistar Albino (WIS) rat strains, prompted by the heightened awareness of such impacts amid the COVID-19 pandemic. This study aims to explore the impact of social isolation on memory, learning, and behavioral changes in middle-aged SD and WIS rat strains and to investigate cortical trace element levels, seeking potential correlations between these levels and the observed behavioral responses to social isolation. Methods: Four groups of 14-month-old male rats were established: control and isolated SDs and WIS rats (CONT-SD, ISO-SD, CONT-WIS, ISO-WIS). Morris Water Maze and Porsolt Forced Swimming tests were conducted for behavioral assessment. Following behavioral tests, rats were sacrificed under general anesthesia, and cortices were isolated for analysis of macro and trace element levels (ICP/MS). Results: In behavioral tests, CONT-SD rats exhibited superior performance in the Morris Water Maze test compared to CONT-WIS rats, but displayed increased depressive behaviors following social isolation, as evident in the Porsolt Forced Swimming test (p < 0.05). ISO-SD rats showed elevated levels of Co and Cu, along with reduced levels of Cs and As, compared to ISO-WIS rats. Moreover, isolation resulted in decreased Cu and Mo levels but increased Rb levels in WIS rats. Comparison of trace element levels in naïve groups from different strains revealed lower Zn levels in the WIS group compared to SD rats. Discussion: The findings suggest that the SD strain learns faster, but is more susceptible to depression after isolation compared to the WIS strain. Increased Co and Cu levels in ISO-SD align with previous findings, indicating potential trace element involvement in stress responses. Understanding these mechanisms could pave the way for preventive treatment strategies or therapeutic targets against the consequences of stressors, contributing to research and measures promoting a balanced diet to mitigate neurobehavioral abnormalities associated with social isolation in the future.
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ChatGPT is a variant of the generative pre-trained transformer (GPT) language model that uses large amounts of text-based training data and a transformer architecture to generate human-like text adjusted to the received prompts. ChatGPT presents several advantages in forensic sciences, namely, constituting a virtual assistant to aid lawyers, judges, and victims in managing and interpreting forensic expert data. But what would happen if ChatGPT began to be used to produce forensic expertise reports? Despite its potential applications, the use of ChatGPT and other Large Language Models and artificial intelligence tools in forensic writing also poses ethical and legal concerns, which are discussed in this perspective together with some expected future perspectives.
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Gums and carrageenans are food additives widely used in food preparations to improve texture and as viscosifiers. Although they are typically added in small amounts, nowadays people tend to use more and more pre-prepared food. In this work, the content of a wide panel of trace elements in commercial products were analyzed. Carrageenans and gums (n = 13) were purchased in the Portuguese market and were from European suppliers. Samples were solubilized by closed-vessel microwave-assisted acid digestion and analyzed by ICP-MS. Globally, the content of essential trace elements decreased in the following order: Fe (on average, on the order of several tens of µg/g) > Mn > Zn > Cr > Cu > Co > Se > Mo (typically < 0.1 µg/g), while the content of non-essential/toxic trace elements decreased in the following order: Al > Sr > Rb > As > Li > Cd > Pb > Hg. The consumption of these food additives can significantly contribute to the daily requirements of some essential trace elements, namely Cr and Mo. The toxic trace elements Cd, As, Pb, and Hg were below the EU regulatory limits in all analyzed samples. Additional research is needed to define the potential risk of introducing toxic trace elements into food products through the use of these additives.
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Previous studies have shown that haemodialysis patients have an increased risk of trace element imbalances. Most studies have determined the concentration of trace elements in serum only, but most trace elements are not uniformly distributed between plasma and blood cells, which justifies separate analysis of the different compartments. In this study, we determined both the serum and whole blood concentration of a wide panel of trace elements (Li, B, Mn, Co, Ni, Cu, Zn, Se, Rb, Sr, Mo, Cd, Pb) in haemodialysis patients and compared them with those of a control group. Whole blood and serum samples were collected during routine laboratory testing of patients undergoing chronic haemodialysis. For comparison purposes, samples from individuals with normal renal function were also analysed. Statistically significant differences (p < 0.05) were found between the two groups for whole blood concentrations of all analysed elements except Zn (p = 0.347). For serum, the difference between groups was statistically significant for all elements (p < 0.05). This study confirms that patients on haemodialysis tend to present significant trace element imbalances. By determining the concentration of trace elements in both whole blood and serum, it was shown that chronic haemodialysis may affect intra- and extracellular blood compartments differently.
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Oligoelementos , Humanos , Diálisis Renal , Plasma/química , LitioRESUMEN
The Invisalign® system (SmartForce® G8) aims to guarantee aesthetics and provide good orthodontic treatment results. Dentoalveolar expansion is possible with clear aligners and can be used to correct dentoalveolar crossbite, resolve crowding or modify the arch shape. Despite the treatment's effectiveness, there is still disagreement among professionals concerning its true clinical potential. This study aimed to analyze the effectiveness and predictability of coronal tooth expansion movement in permanent dentition in patients who had completed the first phase of treatment with Invisalign® orthodontic aligners. MATERIALS AND METHODS: The tooth movement tables of 75 previously selected cases were analyzed in terms of dental-arch width and expansion efficiency, through the Invisalign® platform, considering the pre-treatment (T0), planned treatment (TP) and post-treatment models (T1) using ClinCheck Pro® 6.0 software. All patients were treated by an orthodontic specialist and Invisalign® Diamond Provider in a private practice (T.P.). RESULTS: Difference between T1 and T0: for each maxillary and mandibular measurement, there was a statistically significant difference between pre- and post-aligner treatment values. The greatest amount of expansion occurred in both the upper and the lower premolars. Difference between TP and T1: for each maxillary measurement, statistically significant differences were verified for the molar and canine. At the mandibular level, statistically significant differences were only verified in the first molar. CONCLUSIONS: The Invisalign® clear aligners are effective for simultaneous intra-arch expansion in both jaws.
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Background: Patients on chronic hemodialysis therapy are at high risk of disturbances in trace element status due to both the underlying disease and the hemodialysis process itself. Data on iodine and bromine levels in these patients are scarce. Methods: Using an ICP-MS analytical procedure, serum iodine and bromine levels were determined in a cohort (n = 57) of end-stage renal disease patients on chronic hemodialysis. The results were compared with those of a control group (n = 59). Results: Hemodialysis patients presented serum iodine levels within the normal range, slightly lower than in controls, but without reaching a statistically significant difference (67.6 ± 17.1 µg/L vs. 72.2 ± 14.8 µg/L; p = 0.1252). In contrast, serum bromine levels were much lower in patients (1086 ± 244 µg/L vs. 4137 ± 770 µg/L; p < 0.0001), at values only about 26% of the values observed in controls. Conclusions: Hemodialysis patients had normal serum iodine levels, but highly decreased serum bromine levels. The clinical significance of this finding requires further investigation, but it may be associated with sleep disturbances and fatigue that affect hemodialysis patients.
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The current systematic review appraises the effectiveness of the types of tooth movements performed with Invisalign® clear aligner on the maxillary incisors. An electronic literature search of published trials was performed through PubMed, LILACS, Scopus, Cochrane Library, and Web of Science databases, and selected journals, from 2009 to 2020. Out of 291 references, five relevant publications were identified for analysis: four studies were performed retrospectively and one prospectively, all non-randomized. Despite the limited set of selected articles, the sample size is significant, with 148 subjects included in the reviewed studies involving the orthodontic treatment of upper incisors. We concluded that movements with the Invisalign® clear aligner on the upper incisors present distinct accuracy, possibly related with movement complexity; intrusion of the incisors has low accuracy (in some cases, 0% of accuracy was reported when the tooth extruded), while incisor extrusion exhibit some of the highest accuracy values reported in the included studies (45%-142%, when the achieved movement was greater than the predicted). Besides, axial (i.e., torque and tip) and horizontal (i.e., translation and rotation) movements are usually effective, with accuracy values between 39%-156% and 42%-79%, respectively. Overall, we determined that the efficiency of aligner to reach the desired movements in the upper incisors was low, as often refinements were required in the included studies. The use of aligner features must be more often considered to improve movement accuracy.
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The use of antibiotics in animal production is linked to the emergence and spread of antibiotic-resistant bacteria, a threat to animal, environmental and human health. Copper (Cu) is an essential element in poultry diets and an alternative to antibiotics, supplementing inorganic or organic trace mineral feeds (ITMF/OTMF). However, its contribution to select multidrug-resistant (MDR) and Cu tolerant Enterococcus, a bacteria with a human-animal-environment-food interface, remains uncertain. We evaluated whether feeding chickens with Cu-ITMF or Cu-OTMF contributes to the selection of Cu tolerant and MDR Enterococcus from rearing to slaughter. Animal faeces [2-3-days-old (n = 18); pre-slaughter (n = 16)] and their meat (n = 18), drinking-water (n = 14) and feed (n = 18) from seven intensive farms with ITMF and OTMF flocks (10.000-64.000 animals each; 2019-2020; Portugal) were sampled. Enterococcus were studied by cultural, molecular and whole-genome sequencing methods and Cu concentrations by ICP-MS. Enterococcus (n = 477; 60 % MDR) were identified in 80 % of the samples, with >50 % carrying isolates resistant to tetracycline, quinupristin-dalfopristin, erythromycin, streptomycin, ampicillin or ciprofloxacin. Enterococcus with Cu tolerance genes, especially tcrB ± cueO, were mainly found in faeces (85 %; E. faecium/E. lactis) of ITMF/OTMF flocks. Similar occurrence and load of tcrB ± cueO Enterococcus in the faeces was detected throughout the chickens' lifespan in the ITMF/OTMF flocks, decreasing in meat. Most of the polyclonal MDR Enterococcus population carrying tcrB ± cueO or only cueO (67 %) showed a wild-type phenotype (MICCuSO4 ≤ 12 mM) linked to absence of tcrYAZB or truncated variants, also detected in 85 % of Enterococcus public genomes from poultry. Finally, < 65 µg/g Cu was found in all faecal and meat samples. In conclusion, Cu present in ITMF/OTMF is not selecting Cu tolerant and MDR Enterococcus during chickens' lifespan. However, more studies are needed to assess the minimum concentration of Cu required for MDR bacterial selection and horizontal transfer of antibiotic resistance genes, which would support sustainable practices mitigating antibiotic resistance spread in animal production and the environment beyond.
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Antibacterianos , Enterococcus , Humanos , Animales , Antibacterianos/farmacología , Aves de Corral/microbiología , Cobre/farmacología , Pollos/microbiología , Suplementos Dietéticos , Pruebas de Sensibilidad Microbiana , Farmacorresistencia Bacteriana/genéticaRESUMEN
AIM: To quantify the physiological demands and impact of muscle function t of the Fran workout, one of the most popular CrossFit benchmarks. METHODS: Twenty experienced CrossFitters-16 male: 29 (6) years old and 4 female: 26 (5) years old- performed 3 rounds (with 30-s rests in between) of 21-21, 15-15, and 9-9 front squats to overhead press plus pull-up repetitions. Oxygen uptake and heart rate were measured at baseline, during the workout, and in the recovery period. Rating of perceived exertion, blood lactate, and glucose concentrations were assessed at rest, during the intervals, and in the recovery period. Muscular fatigue was also monitored at rest and at 5 minutes, 30 minutes, and 24 hours postexercise. Repeated-measures analysis of variance was performed to compare time points. RESULTS: Aerobic (52%-29%) and anaerobic alactic (30%-23%) energy contributions decreased and the anaerobic lactic contribution increased (18%-48%) across the 3 rounds of the Fran workout. Countermovement jump height decreased by 8% (-12 to -3) mean change (95% CI), flight duration by 14% (-19 to -7), maximum velocity by 3% (-5 to -0.1), peak force 4% (-7 to -0.1), and physical performance (plank prone 47% [-54 to -38]) were observed. CONCLUSIONS: It appears that the Fran workout is a physically demanding activity that recruits energy from both aerobic and anaerobic systems. This severe-intensity workout evokes substantial postexercise fatigue and corresponding reduction in muscle function.
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Fatiga Muscular , Niño , Preescolar , Femenino , Humanos , Masculino , Metabolismo Energético , Frecuencia Cardíaca/fisiología , Fatiga Muscular/fisiologíaRESUMEN
BACKGROUND: Clear aligners (CA) are used 22 h daily, creating a bite-block effect. This work aims to (i) analyze occlusal changes before the beginning of treatment, after the first set of CA and after the use of additional aligners; (ii) compare planned occlusal contacts with the ones obtained after the first set of CA; (iii) analyze the occlusal changes occurred after reaching the orthodontic goals after 3 months of using CA only at night; (iv) evaluate and characterize which tooth movements did not allow the treatment to be completed at the end of the first set of aligners, and finally (v) verify the possible relation between the changes in occlusal contact and areas and parameters such as case complexity and facial biotype. MATERIALS AND METHODS: A quantitative, comparative, and observational longitudinal cohort study design was implemented to evaluate the clinical data and the complexity levels of cases receiving CA. A non-probabilistic and convenience sample of 82 individuals was recruited. The orthodontic malocclusion traits were classified as simple, moderate, or complex corrections based on the basis of the Align® recommendations with the Invisalign® evaluation tool. According to the Invisalign® criteria, patients need only one complex problem for their case to be classified as complex. Meshlab® v. 2022.02, ClinCheck® version Pro 6.0, My-Itero® version 2.7.9.601 5d plus, and IBM® SPSS Statistics software (Statistical Program for Social Sciences), version 27.0 for Windows were the software® used. RESULTS: A statistically significant decrease in area and occlusal contacts number were observed from before the start of orthodontic treatment (T0) to the end of treatment (T1). The changes in the occlusal area (from T0 to T1) were statistically different between hyperdivergent (28.24 [15.51-40.91]) and hypodivergent (16.23 [8.11-24.97]) biotypes (p = 0.031). A significant difference between the hyperdivergent (4.0 [2.0-5.0]) and normodivergent (5.5 [4.0-8.0]) group was found in T1 for the anterior contacts (p = 0.044). Anterior contacts obtained were significantly higher than the planned (p = 0.037) Between T1 and T2 statistically significant increases of occlusal areas, posterior and total contacts were observed. CONCLUSIONS: Occlusal contact and area were decreased, either at the end of the first set or after the use of additional aligners. Anterior occlusal contacts obtained were higher than planned as opposed to posterior occlusal contacts obtained. The hardest tooth movements to achieve to complete the treatment were distalization, rotation, and posterior extrusion. After completing orthodontic treatment (T1) to 3 months after (T2) using additional aligners only at night, posterior occlusal contacts were significantly increased, which could be due to the natural settling of the teeth in this period.
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Cobalt (Co), copper (Cu), manganese (Mn), molybdenum (Mo), and zinc (Zn) are essential trace elements (ETEs) and important cofactors for intermediary metabolism or redox balance. These ETEs are crucial during pregnancy, their role on specific pregnancy outcomes is largely unknown. This prospective study (#NCT04010708) aimed to assess urinary levels of these ETEs in pregnancy and to evaluate their association with pregnancy outcomes. First trimester pregnant women of Porto and Lisbon provided a random spot urine sample, and sociodemographic and lifestyle data. Clinical data were obtained from clinical records. Urinary ETEs were quantified by inductively coupled plasma mass spectrometry (ICP-MS). A total of 635 mother:child pairs were included. Having urinary Zn levels above the 50th percentile (P50) was an independent risk factor for pre-eclampsia (PE) (aOR [95% CI]: 5.350 [1.044-27.423], p = 0.044). Urinary Zn levels above the P50 decreased the risk of small for gestational age (SGA) birth head circumference (aOR [95% CI]: 0.315 [0.113-0.883], p = 0.028), but it increased the risk SGA length (aOR [95% CI]: 2.531 [1.057-6.062], p = 0.037). This study may provide valuable information for public health policies related to prenatal nutrition, while informing future efforts to de-fine urinary reference intervals for ETEs in pregnant women.