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1.

Wild-type FLT3 and FLT3 ITD exhibit similar ligand-induced internalization characteristics.

Kellner, Fabienne; Keil, Andreas; Schindler, Katrin; Tschongov, Todor; Hünninger, Kerstin; Loercher, Hannah; Rhein, Peter; Böhmer, Sylvia-Annette; Böhmer, Frank-D; Müller, Jörg P.

J Cell Mol Med; 24(8): 4668-4676, 2020 04.

Artículo en Inglés | MEDLINE | ID: mdl-32155324

2.

The protein-tyrosine phosphatase DEP-1 promotes migration and phagocytic activity of microglial cells in part through negative regulation of fyn tyrosine kinase.

Schneble, Nadine; Müller, Julia; Kliche, Stefanie; Bauer, Reinhard; Wetzker, Reinhard; Böhmer, Frank-D; Wang, Zhao-Qi; Müller, Jörg P.

Glia; 65(2): 416-428, 2017 02.

Artículo en Inglés | MEDLINE | ID: mdl-27859601

3.

Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes.

Choudhary, Chunaram; Olsen, Jesper V; Brandts, Christian; Cox, Jürgen; Reddy, Pavankumar N G; Böhmer, Frank D; Gerke, Volker; Schmidt-Arras, Dirk-E; Berdel, Wolfgang E; Müller-Tidow, Carsten; Mann, Matthias; Serve, Hubert.

Mol Cell; 36(2): 326-39, 2009 Oct 23.

Artículo en Inglés | MEDLINE | ID: mdl-19854140

4.

A phosphorylation-acetylation switch regulates STAT1 signaling.

Krämer, Oliver H; Knauer, Shirley K; Greiner, Georg; Jandt, Enrico; Reichardt, Sigrid; Gührs, Karl-Heinz; Stauber, Roland H; Böhmer, Frank D; Heinzel, Thorsten.

Genes Dev; 23(2): 223-35, 2009 Jan 15.

Artículo en Inglés | MEDLINE | ID: mdl-19171783

5.

Features of Ras activation by a mislocalized oncogenic tyrosine kinase: FLT3 ITD signals through K-Ras at the plasma membrane of acute myeloid leukemia cells.

Köthe, Susanne; Müller, Jörg P; Böhmer, Sylvia-Annette; Tschongov, Todor; Fricke, Melanie; Koch, Sina; Thiede, Christian; Requardt, Robert P; Rubio, Ignacio; Böhmer, Frank D.

J Cell Sci; 126(Pt 20): 4746-55, 2013 Oct 15.

Artículo en Inglés | MEDLINE | ID: mdl-23943874

6.

Deficiency of the protein-tyrosine phosphatase DEP-1/PTPRJ promotes matrix metalloproteinase-9 expression in meningioma cells.

Petermann, Astrid; Stampnik, Yvonn; Cui, Yan; Morrison, Helen; Pachow, Doreen; Kliese, Nadine; Mawrin, Christian; Böhmer, Frank-D.

J Neurooncol; 122(3): 451-9, 2015 May.

Artículo en Inglés | MEDLINE | ID: mdl-25672645

7.

Protein-tyrosine phosphatases and cancer.

Ostman, Arne; Hellberg, Carina; Böhmer, Frank D.

Nat Rev Cancer; 6(4): 307-20, 2006 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-16557282

8.

Cell transformation by FLT3 ITD in acute myeloid leukemia involves oxidative inactivation of the tumor suppressor protein-tyrosine phosphatase DEP-1/ PTPRJ.

Godfrey, Rinesh; Arora, Deepika; Bauer, Reinhard; Stopp, Sabine; Müller, Jörg P; Heinrich, Theresa; Böhmer, Sylvia-Annette; Dagnell, Markus; Schnetzke, Ulf; Scholl, Sebastian; Östman, Arne; Böhmer, Frank-D.

Blood; 119(19): 4499-511, 2012 May 10.

Artículo en Inglés | MEDLINE | ID: mdl-22438257

9.

Loss of DEP-1 (Ptprj) promotes myeloproliferative disease in FLT3-ITD acute myeloid leukemia.

Kresinsky, Anne; Bauer, Reinhard; Schnöder, Tina M; Berg, Tobias; Meyer, Daria; Ast, Volker; König, Rainer; Serve, Hubert; Heidel, Florian H; Böhmer, Frank-D; Müller, Jörg P.

Haematologica; 103(11): e505-e509, 2018 11.

Artículo en Inglés | MEDLINE | ID: mdl-29880609

10.

Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling.

Arora, Deepika; Stopp, Sabine; Böhmer, Sylvia-Annette; Schons, Julia; Godfrey, Rinesh; Masson, Kristina; Razumovskaya, Elena; Rönnstrand, Lars; Tänzer, Simone; Bauer, Reinhard; Böhmer, Frank-D; Müller, Jörg P.

J Biol Chem; 286(13): 10918-29, 2011 Apr 01.

Artículo en Inglés | MEDLINE | ID: mdl-21262971

11.

Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells: FLT3 ITD sustains high levels of DUSP6 expression.

Arora, Deepika; Köthe, Susanne; van den Eijnden, Monique; Hooft van Huijsduijnen, Rob; Heidel, Florian; Fischer, Thomas; Scholl, Sebastian; Tölle, Benjamin; Böhmer, Sylvia-Annette; Lennartsson, Johan; Isken, Fabienne; Müller-Tidow, Carsten; Böhmer, Frank-D.

Cell Commun Signal; 10(1): 19, 2012 Jul 11.

Artículo en Inglés | MEDLINE | ID: mdl-22784513

12.

Novel inhibitors of epidermal growth factor receptor: (4-(Arylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)(1H-indol-2-yl)methanones and (1H-indol-2-yl)(4-(phenylamino)thieno[2,3-d]pyrimidin-6-yl)methanones.

Beckers, Thomas; Sellmer, Andreas; Eichhorn, Emerich; Pongratz, Herwig; Schächtele, Christoph; Totzke, Frank; Kelter, Gerhard; Krumbach, Rebekka; Fiebig, Heinz-Herbert; Böhmer, Frank-D; Mahboobi, Siavosh.

Bioorg Med Chem; 20(1): 125-36, 2012 Jan 01.

Artículo en Inglés | MEDLINE | ID: mdl-22169601

13.

Context-specific effects of NOX4 inactivation in acute myeloid leukemia (AML).

Demircan, Muhammed Burak; Schnoeder, Tina M; Mgbecheta, Peter C; Schröder, Katrin; Böhmer, Frank-D; Heidel, Florian H.

J Cancer Res Clin Oncol; 148(8): 1983-1990, 2022 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-35348887

14.

Combined Activity of the Redox-Modulating Compound Setanaxib (GKT137831) with Cytotoxic Agents in the Killing of Acute Myeloid Leukemia Cells.

Demircan, Muhammed Burak; Mgbecheta, Peter C; Kresinsky, Anne; Schnoeder, Tina M; Schröder, Katrin; Heidel, Florian H; Böhmer, Frank D.

Antioxidants (Basel); 11(3)2022 Mar 08.

Artículo en Inglés | MEDLINE | ID: mdl-35326163

15.

A novel molecular mechanism of primary resistance to FLT3-kinase inhibitors in AML.

Breitenbuecher, Frank; Markova, Boyka; Kasper, Stefan; Carius, Birgit; Stauder, Torsten; Böhmer, Frank D; Masson, Kristina; Rönnstrand, Lars; Huber, Christoph; Kindler, Thomas; Fischer, Thomas.

Blood; 113(17): 4063-73, 2009 Apr 23.

Artículo en Inglés | MEDLINE | ID: mdl-19144992

16.

Anchoring of FLT3 in the endoplasmic reticulum alters signaling quality.

Schmidt-Arras, Dirk; Böhmer, Sylvia-Annette; Koch, Sina; Müller, Jörg P; Blei, Lutz; Cornils, Hauke; Bauer, Reinhard; Korasikha, Sridhar; Thiede, Christian; Böhmer, Frank-D.

Blood; 113(15): 3568-76, 2009 Apr 09.

Artículo en Inglés | MEDLINE | ID: mdl-19204327

17.

EGF/TGFß1 co-stimulation of oral squamous cell carcinoma cells causes an epithelial-mesenchymal transition cell phenotype expressing laminin 332.

Richter, Petra; Umbreit, Claudia; Franz, Marcus; Berndt, Angela; Grimm, Susanne; Uecker, Andrea; Böhmer, Frank D; Kosmehl, Hartwig; Berndt, Alexander.

J Oral Pathol Med; 40(1): 46-54, 2011 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-20819124

18.

Diabetes mellitus activates signal transduction pathways resulting in vascular endothelial growth factor resistance of human monocytes.

Tchaikovski, Vadim; Olieslagers, Servé; Böhmer, Frank-D; Waltenberger, Johannes.

Circulation; 120(2): 150-9, 2009 Jul 14.

Artículo en Inglés | MEDLINE | ID: mdl-19564559

19.

Chimeric tyrosine kinase-HDAC inhibitors as antiproliferative agents.

Uecker, Andrea; Sicker, Marit; Beckers, Thomas; Mahboobi, Siavosh; Hägerstrand, Daniel; Ostman, Arne; Böhmer, Frank-D.

Anticancer Drugs; 21(8): 759-65, 2010 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-20613486

20.

The structure of the 5'-end of the protein-tyrosine phosphatase PTPRJ mRNA reveals a novel mechanism for translation attenuation.

Karagyozov, Luchezar; Godfrey, Rinesh; Böhmer, Sylvia-Annette; Petermann, Astrid; Hölters, Sebastian; Ostman, Arne; Böhmer, Frank-D.

Nucleic Acids Res; 36(13): 4443-53, 2008 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-18603590

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