Analysis of the efficiency of osmotic concentration in Wistar and Brattleboro rats under the effect of desmopressin.

We studied the effect of vasopressin V2 receptor agonist (desmopressin, 5 µg/100 g body weight for 2 days) on the efficiency of osmotic concentration in Wistar rats and homozygous Brattleboro rats defective by the synthesis of antidiuretic hormone. Specific differences in the reaction of the osmotic concentration system components (urine osmolality and urea, sodium, and potassium content in the renal tissue) involved in the realization of the hydroosmotic effect of the hormone depend on genetically determined capacity to vasopressin synthesis in these animals.