Computational design and evaluation of the mechanical and electrical behavior of a piezoelectric scaffold: a preclinical study.

Piezoelectric scaffolds have been recently developed to explore their potential to enhance the bone regeneration process using the concept of piezoelectricity, which also inherently occurs in bone. In addition to providing mechanical support during bone healing, with a suitable design, they are supposed to produce electrical signals that ought to favor the cell responses. In this study, using finite element analysis (FEA), a piezoelectric scaffold was designed with the aim of providing favorable ranges of mechanical and electrical signals when implanted in a large bone defect in a large animal model, so that it could inform future pre-clinical studies. A parametric analysis was then performed to evaluate the effect of the scaffold design parameters with regard to the piezoelectric behavior of the scaffold. The designed scaffold consisted of a porous strut-like structure with piezoelectric patches covering its free surfaces within the scaffold pores. The results showed that titanium or PCL for the scaffold and barium titanate (BT) for the piezoelectric patches are a promising material combination to generate favorable ranges of voltage, as reported in experimental studies. Furthermore, the analysis of variance showed the thickness of the piezoelectric patches to be the most influential geometrical parameter on the generation of electrical signals in the scaffold. This study shows the potential of computer tools for the optimization of scaffold designs and suggests that patches of piezoelectric material, attached to the scaffold surfaces, can deliver favorable ranges of electrical stimuli to the cells that might promote bone regeneration.

Biomechanical modeling of spinal ligaments: finite element analysis of L4-L5 spinal segment.

The complex mechanical structure of spine is usually simplified in finite element (FE) modes. In this study, different 3D models of L4-L5 spinal segment distinguished by their ligament modelling were developed (1D truss, 2D shell and 3D space truss elements). All models could be considered validated with respect to range of motion and intradiscal pressure, although their ligament stresses/forces were substantially different. The models with 2D shell and 3D space truss ligaments showed the stress distribution and identified the potential failure/injury locations in ligaments. The model with 3D space truss ligaments showed the stress/force direction (representing collagen fiber directions).