Detalles de la búsqueda
1.
2-(Halogenated Phenyl) acetamides and propanamides as potent TRPV1 antagonists.
Bioorg Med Chem Lett;
48: 128266, 2021 09 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34273488
2.
Discovery of 1-(1H-indazol-4-yl)-3-((1-phenyl-1H-pyrazol-5-yl)methyl) ureas as potent and thermoneutral TRPV1 antagonists.
Bioorg Med Chem Lett;
30(23): 127548, 2020 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32931910
3.
Discovery of indane propanamides as potent and selective TRPV1 antagonists.
Bioorg Med Chem Lett;
30(3): 126838, 2020 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31864799
4.
RNA interference-based functional knockdown of the voltage-gated potassium channel Kv7.2 in dorsal root ganglion neurons after in vitro and in vivo gene transfer by adeno-associated virus vectors.
Mol Pain;
14: 1744806917749669, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-29212407
5.
Discovery of 2-(3,5-difluoro-4-methylsulfonaminophenyl)propanamides as potent TRPV1 antagonists.
Bioorg Med Chem Lett;
28(14): 2539-2542, 2018 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29884534
6.
4-Aminophenyl acetamides and propanamides as potent transient receptor potential vanilloid 1 (TRPV1) ligands.
Bioorg Med Chem;
26(15): 4509-4517, 2018 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30078610
7.
Novel Function of Serine Protease HTRA1 in Inhibiting Adipogenic Differentiation of Human Mesenchymal Stem Cells via MAP Kinase-Mediated MMP Upregulation.
Stem Cells;
34(6): 1601-14, 2016 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-26864869
8.
Pyrazole C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists.
Bioorg Med Chem Lett;
27(18): 4383-4388, 2017 09 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28838698
9.
t-Butyl pyridine and phenyl C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists.
Bioorg Med Chem;
25(8): 2451-2462, 2017 04 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28314510
10.
6,6-Fused heterocyclic ureas as highly potent TRPV1 antagonists.
Bioorg Med Chem Lett;
25(4): 803-6, 2015 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25597011
11.
α-Substituted 2-(3-fluoro-4-methylsulfonamidophenyl)acetamides as potent TRPV1 antagonists.
Bioorg Med Chem Lett;
25(11): 2326-30, 2015 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25937016
12.
Structure activity relationships of benzyl C-region analogs of 2-(3-fluoro-4-methylsulfonamidophenyl)propanamides as potent TRPV1 antagonists.
Bioorg Med Chem;
23(21): 6844-54, 2015 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26474664
13.
2-Aryl substituted pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as highly potent TRPV1 antagonists.
Bioorg Med Chem Lett;
24(16): 4044-7, 2014 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25011915
14.
2-Alkyl/alkenyl substituted pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as highly potent TRPV1 antagonists.
Bioorg Med Chem Lett;
24(16): 4039-43, 2014 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24948568
15.
Salt bridge switching from Arg290/Glu167 to Arg290/ATP promotes the closed-to-open transition of the P2X2 receptor.
Mol Pharmacol;
83(1): 73-84, 2013 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-23041661
16.
Detrimental role for human high temperature requirement serine protease A1 (HTRA1) in the pathogenesis of intervertebral disc (IVD) degeneration.
J Biol Chem;
287(25): 21335-45, 2012 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22556410
17.
Human serine protease HTRA1 positively regulates osteogenesis of human bone marrow-derived mesenchymal stem cells and mineralization of differentiating bone-forming cells through the modulation of extracellular matrix protein.
Stem Cells;
30(10): 2271-82, 2012 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-22865667
18.
TRPV1 antagonist with high analgesic efficacy: 2-Thio pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides.
Bioorg Med Chem;
21(21): 6657-64, 2013 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24035514
19.
Emergence of nociceptive functionality and opioid signaling in human induced pluripotent stem cell-derived sensory neurons.
Pain;
164(8): 1718-1733, 2023 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36727909
20.
A novel dual mode-of-action anti-hyperalgesic compound in rats which is neuroprotective and promotes neuroregeneration.
Eur J Pharmacol;
923: 174935, 2022 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35378102