Detalles de la búsqueda
1.
Pharmacology of a Potent and Novel Inhibitor of the NOD-Like Receptor Pyrin Domain-Containing Protein 3 (NLRP3) Inflammasome that Attenuates Development of Nonalcoholic Steatohepatitis and Liver Fibrosis.
J Pharmacol Exp Ther;
386(2): 242-258, 2023 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-37308266
2.
Lysyl oxidase like-2 contributes to renal fibrosis in Col4α3/Alport mice.
Kidney Int;
94(2): 303-314, 2018 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29759420
3.
Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis.
J Pharmacol Exp Ther;
360(1): 1-13, 2017 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-27754931
4.
Autotaxin activity increases locally following lung injury, but is not required for pulmonary lysophosphatidic acid production or fibrosis.
FASEB J;
30(6): 2435-50, 2016 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-27006447
5.
Structural Basis for Inhibition of Human Autotaxin by Four Potent Compounds with Distinct Modes of Binding.
Mol Pharmacol;
88(6): 982-92, 2015 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-26371182
6.
Pharmacodynamics, pharmacokinetics and safety of GSK2190915, a novel oral anti-inflammatory 5-lipoxygenase-activating protein inhibitor.
Br J Clin Pharmacol;
75(3): 779-90, 2013 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-22803688
7.
JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders.
Sci Rep;
13(1): 13524, 2023 08 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-37598239
8.
Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma.
Arthritis Rheum;
63(5): 1405-15, 2011 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-21305523
9.
Overcoming Preclinical Safety Obstacles to Discover (S)-N-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor.
J Med Chem;
65(21): 14721-14739, 2022 11 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-36279149
10.
Pharmacology of AM211, a potent and selective prostaglandin D2 receptor type 2 antagonist that is active in animal models of allergic inflammation.
J Pharmacol Exp Ther;
338(1): 290-301, 2011 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-21487069
11.
Discovery and optimization of a biphenylacetic acid series of prostaglandin D2 receptor DP2 antagonists with efficacy in a murine model of allergic rhinitis.
Bioorg Med Chem Lett;
21(21): 6608-12, 2011 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21958540
12.
Sodium [2'-[(cyclopropanecarbonyl-ethyl-amino)-methyl]-4'-(6-ethoxy-pyridin-3-yl)-6-methoxy-biphenyl-3-yl]-acetate (AM432): a potent, selective prostaglandin D2 receptor antagonist.
Bioorg Med Chem Lett;
21(3): 1036-40, 2011 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21211969
13.
Pharmacological blockade of the DP2 receptor inhibits cigarette smoke-induced inflammation, mucus cell metaplasia, and epithelial hyperplasia in the mouse lung.
J Pharmacol Exp Ther;
332(3): 764-75, 2010 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-19996299
14.
5-Lipoxygenase-activating protein inhibitors. Part 3: 3-{3-tert-Butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM643)-A potent FLAP inhibitor suitable for topical administration.
Bioorg Med Chem Lett;
20(15): 4598-601, 2010 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20566292
15.
5-Lipoxygenase-activating protein inhibitors. Part 2: 3-{5-((S)-1-Acetyl-2,3-dihydro-1H-indol-2-ylmethoxy)-3-tert-butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-1H-indol-2-yl}-2,2-dimethyl-propionic acid (AM679)--a potent FLAP inhibitor.
Bioorg Med Chem Lett;
20(1): 213-7, 2010 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19914828
16.
Pharmacological characterization of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103), a novel selective 5-lipoxygenase-activating protein inhibitor that reduces acute and chronic inflammation.
J Pharmacol Exp Ther;
331(3): 1042-50, 2009 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-19749079
17.
Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine model of allergic rhinitis.
Bioorg Med Chem Lett;
19(16): 4647-51, 2009 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19608418
18.
The involvement of autotaxin in renal interstitial fibrosis through regulation of fibroblast functions and induction of vascular leakage.
Sci Rep;
9(1): 7414, 2019 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31092842
19.
Author Correction: JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders.
Sci Rep;
13(1): 20081, 2023 Nov 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-37973811
20.
Small Molecule Lysyl Oxidase-like 2 (LOXL2) Inhibitors: The Identification of an Inhibitor Selective for LOXL2 over LOX.
ACS Med Chem Lett;
8(4): 423-427, 2017 Apr 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-28435530