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1.

Development of a robust crystallization platform for immune receptor TREM2 using a crystallization chaperone strategy.

Byrne, Noel J; Lee, Amy C; Kostas, James; Reid, John C; Partridge, Andrea T; So, Sung-Sau; Cowan, Joseph E; Abeywickrema, Pravien; Huang, Hua; Zebisch, Matthias; Barker, John J; Soisson, Stephen M; Brooun, Alexei; Su, Hua-Poo.

Protein Expr Purif; 179: 105796, 2021 03.

Artículo en Inglés | MEDLINE | ID: mdl-33221505

2.

Design, synthesis and structure-activity relationships of a novel class of sulfonylpyridine inhibitors of Interleukin-2 inducible T-cell kinase (ITK).

Trani, Giancarlo; Barker, John J; Bromidge, Steven M; Brookfield, Frederick A; Burch, Jason D; Chen, Yuan; Eigenbrot, Charles; Heifetz, Alexander; Ismaili, M Hicham A; Johnson, Adam; Krülle, Thomas M; MacKinnon, Colin H; Maghames, Rosemary; McEwan, Paul A; Montalbetti, Christian A G N; Ortwine, Daniel F; Pérez-Fuertes, Yolanda; Vaidya, Darshan G; Wang, Xiaolu; Zarrin, Ali A; Pei, Zhonghua.

Bioorg Med Chem Lett; 24(24): 5818-5823, 2014 Dec 15.

Artículo en Inglés | MEDLINE | ID: mdl-25455497

3.

Structural insights into selective small molecule activation of PKG1α.

Metwally, Essam; Mak, Victor; Soriano, Aileen; Zebisch, Matthias; Silvestre, H Leonardo; McEwan, Paul A; Ermakov, Grigori; Beaumont, Maribel; Tawa, Paul; Barker, John J; Yen, Rose; Patel, Akash; Lim, Yeon-Hee; Healy, David; Hanisak, Jennifer; Cheng, Alan C; Greshock, Tom; Fischmann, Thierry O.

Commun Biol; 6(1): 798, 2023 07 31.

Artículo en Inglés | MEDLINE | ID: mdl-37524852

4.

HCV NS5B polymerase inhibitors 2: Synthesis and in vitro activity of (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives.

Wang, Guangyi; Lei, Huoxing; Wang, Xiaofang; Das, Debasis; Hong, Jian; Mackinnon, Colin H; Coulter, Thomas S; Montalbetti, Christian A G N; Mears, Richard; Gai, Xinjie; Bailey, Sarah E; Ruhrmund, Donald; Hooi, Lisa; Misialek, Shawn; Rajagopalan, P T Ravi; Cheng, Robert K Y; Barker, John J; Felicetti, Brunella; Schönfeld, Dorian L; Stoycheva, Antitsa; Buckman, Brad O; Kossen, Karl; Seiwert, Scott D; Beigelman, Leonid.

Bioorg Med Chem Lett; 19(15): 4480-3, 2009 Aug 01.

Artículo en Inglés | MEDLINE | ID: mdl-19500983

5.

The multiple roles of computational chemistry in fragment-based drug design.

Law, Richard; Barker, Oliver; Barker, John J; Hesterkamp, Thomas; Godemann, Robert; Andersen, Ole; Fryatt, Tara; Courtney, Steve; Hallett, Dave; Whittaker, Mark.

J Comput Aided Mol Des; 23(8): 459-73, 2009 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-19533374

6.

High-Throughput Production of Proteins in E. coli for Structural Studies.

Black, Charikleia; Barker, John J; Hitchman, Richard B; Kwong, Hok Sau; Festenstein, Sam; Acton, Thomas B.

Methods Mol Biol; 1586: 359-371, 2017.

Artículo en Inglés | MEDLINE | ID: mdl-28470618

7.

Antibacterial drug discovery and structure-based design.

Barker, John J.

Drug Discov Today; 11(9-10): 391-404, 2006 May.

Artículo en Inglés | MEDLINE | ID: mdl-16635801

8.

Structural and biochemical studies of a moderately thermophilic exonuclease I from Methylocaldum szegediense.

Fei, Li; Tian, SiSi; Moysey, Ruth; Misca, Mihaela; Barker, John J; Smith, Myron A; McEwan, Paul A; Pilka, Ewa S; Crawley, Lauren; Evans, Tom; Sun, Dapeng.

PLoS One; 10(2): e0117470, 2015.

Artículo en Inglés | MEDLINE | ID: mdl-25658953

9.

Tetrahydroindazoles as Interleukin-2 Inducible T-Cell Kinase Inhibitors. Part II. Second-Generation Analogues with Enhanced Potency, Selectivity, and Pharmacodynamic Modulation in Vivo.

Burch, Jason D; Barrett, Kathy; Chen, Yuan; DeVoss, Jason; Eigenbrot, Charles; Goldsmith, Richard; Ismaili, M Hicham A; Lau, Kevin; Lin, Zhonghua; Ortwine, Daniel F; Zarrin, Ali A; McEwan, Paul A; Barker, John J; Ellebrandt, Claire; Kordt, Daniel; Stein, Daniel B; Wang, Xiaolu; Chen, Yong; Hu, Baihua; Xu, Xiaofeng; Yuen, Po-Wai; Zhang, Yamin; Pei, Zhonghua.

J Med Chem; 58(9): 3806-16, 2015 May 14.

Artículo en Inglés | MEDLINE | ID: mdl-25844760

10.

Inhibitors of phosphopantetheine adenylyltransferase.

Zhao, Lihua; Allanson, Nigel M; Thomson, Samantha P; Maclean, John K F; Barker, John J; Primrose, William U; Tyler, Paul D; Lewendon, Ann.

Eur J Med Chem; 38(4): 345-9, 2003 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-12750020

11.

Property- and structure-guided discovery of a tetrahydroindazole series of interleukin-2 inducible T-cell kinase inhibitors.

Burch, Jason D; Lau, Kevin; Barker, John J; Brookfield, Fred; Chen, Yong; Chen, Yuan; Eigenbrot, Charles; Ellebrandt, Claire; Ismaili, M Hicham A; Johnson, Adam; Kordt, Daniel; MacKinnon, Colin H; McEwan, Paul A; Ortwine, Daniel F; Stein, Daniel B; Wang, Xiaolu; Winkler, Dirk; Yuen, Po-Wai; Zhang, Yamin; Zarrin, Ali A; Pei, Zhonghua.

J Med Chem; 57(13): 5714-27, 2014 Jul 10.

Artículo en Inglés | MEDLINE | ID: mdl-24918870

12.

Binding mode and structure-activity relationships around direct inhibitors of the Nrf2-Keap1 complex.

Jnoff, Eric; Albrecht, Claudia; Barker, John J; Barker, Oliver; Beaumont, Edward; Bromidge, Steven; Brookfield, Frederick; Brooks, Mark; Bubert, Christian; Ceska, Tom; Corden, Vincent; Dawson, Graham; Duclos, Stephanie; Fryatt, Tara; Genicot, Christophe; Jigorel, Emilie; Kwong, Jason; Maghames, Rosemary; Mushi, Innocent; Pike, Richard; Sands, Zara A; Smith, Myron A; Stimson, Christopher C; Courade, Jean-Philippe.

ChemMedChem; 9(4): 699-705, 2014 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-24504667

13.

Discovery and structure-activity relationship of potent and selective covalent inhibitors of transglutaminase 2 for Huntington's disease.

Prime, Michael E; Andersen, Ole A; Barker, John J; Brooks, Mark A; Cheng, Robert K Y; Toogood-Johnson, Ian; Courtney, Stephen M; Brookfield, Frederick A; Yarnold, Christopher J; Marston, Richard W; Johnson, Peter D; Johnsen, Siw F; Palfrey, Jordan J; Vaidya, Darshan; Erfan, Sayeh; Ichihara, Osamu; Felicetti, Brunella; Palan, Shilpa; Pedret-Dunn, Anna; Schaertl, Sabine; Sternberger, Ina; Ebneth, Andreas; Scheel, Andreas; Winkler, Dirk; Toledo-Sherman, Leticia; Beconi, Maria; Macdonald, Douglas; Muñoz-Sanjuan, Ignacio; Dominguez, Celia; Wityak, John.

J Med Chem; 55(3): 1021-46, 2012 Feb 09.

Artículo en Inglés | MEDLINE | ID: mdl-22224594

14.

Fragment-based identification of Hsp90 inhibitors.

Barker, John J; Barker, Oliver; Boggio, Roberto; Chauhan, Viddhata; Cheng, Robert K Y; Corden, Vincent; Courtney, Stephen M; Edwards, Neil; Falque, Virginie M; Fusar, Fulvia; Gardiner, Mihaly; Hamelin, Estelle M N; Hesterkamp, Thomas; Ichihara, Osamu; Jones, Richard S; Mather, Owen; Mercurio, Ciro; Minucci, Saverio; Montalbetti, Christian A G N; Müller, Annett; Patel, Deepti; Phillips, Banu G; Varasi, Mario; Whittaker, Mark; Winkler, Dirk; Yarnold, Christopher J.

ChemMedChem; 4(6): 963-6, 2009 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-19301319

15.

Discovery of a novel Hsp90 inhibitor by fragment linking.

Barker, John J; Barker, Oliver; Courtney, Stephen M; Gardiner, Mihaly; Hesterkamp, Thomas; Ichihara, Osamu; Mather, Owen; Montalbetti, Christian A G N; Müller, Annett; Varasi, Mario; Whittaker, Mark; Yarnold, Christopher J.

ChemMedChem; 5(10): 1697-700, 2010 Oct 04.

Artículo en Inglés | MEDLINE | ID: mdl-20665758

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