1.
J Org Chem
; 84(8): 4735-4747, 2019 04 19.
Artículo
en Inglés
| MEDLINE
| ID: mdl-30352146
RESUMEN
A multidisciplinary approach covering synthetic, physical, and analytical chemistry, high-throughput experimentation and experimental design, process engineering, and solid-state chemistry is used to develop a large-scale (kilomole) Suzuki-Miyaura process. Working against clear criteria and targets, a full process investigation and optimization package is described highlighting how and why key decisions are made in the development of large-scale pharmaceutical processes.