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1.
Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor.
Nature;
534(7606): 272-6, 2016 06 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27279227
2.
Alkynyl Benzoxazines and Dihydroquinazolines as Cysteine Targeting Covalent Warheads and Their Application in Identification of Selective Irreversible Kinase Inhibitors.
J Am Chem Soc;
142(23): 10358-10372, 2020 06 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32412754
3.
Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12C with Demonstrable CNS Penetration.
J Med Chem;
66(13): 9147-9160, 2023 07 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-37395055
4.
Accelerating the Validation of Endogenous On-Target Engagement and In Cellulo Kinetic Assessment for Covalent Inhibitors of KRASG12C in Early Drug Discovery.
ACS Chem Biol;
17(8): 2366-2376, 2022 08 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-35881961
5.
Optimization of hERG and Pharmacokinetic Properties for Basic Dihydro-8H-purin-8-one Inhibitors of DNA-PK.
ACS Med Chem Lett;
13(8): 1295-1301, 2022 Aug 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-35978693
6.
A Novel High-Throughput FLIPR Tetra-Based Method for Capturing Highly Confluent Kinetic Data for Structure-Kinetic Relationship Guided Early Drug Discovery.
SLAS Discov;
26(5): 684-697, 2021 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-33783249
7.
Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs.
J Med Chem;
64(19): 14498-14512, 2021 10 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-34570508
8.
The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor.
J Med Chem;
63(7): 3461-3471, 2020 04 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-31851518
9.
Crystal structure of human MMP9 in complex with a reverse hydroxamate inhibitor.
J Mol Biol;
319(1): 173-81, 2002 May 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-12051944
10.
Development of a high-throughput method for preparing human urine for two-dimensional electrophoresis.
Proteomics;
5(9): 2315-8, 2005 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-15887186
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