RESUMEN
Common marmosets (Callithrix jacchus) were trained to perform daily position discrimination learning tasks in a Wisconsin General Test Apparatus. Acetylcholine receptor blockade with scopolamine was found to impair position learning. Testing on the day after scopolamine treatment suggested that a task learnt under scopolamine was not encoded into long term memory. Acetylcholine depletion achieved by the intraventricular injection of hemicholinium 4 h before testing resulted in a profound impairment of position discrimination learning. It is suggested that central acetylcholine depletion in primates may provide a useful model of senile dementia.
Asunto(s)
Aprendizaje Discriminativo/efectos de los fármacos , Hemicolinio 3/farmacología , Receptores Colinérgicos/efectos de los fármacos , Escopolamina/farmacología , Animales , Callitrichinae , Femenino , Inyecciones Intraventriculares , Masculino , Memoria/efectos de los fármacos , Receptores Colinérgicos/fisiologíaRESUMEN
We herein report a case of a 33-year-old man in remission from Hodgkin lymphoma, who presented with reduced potency and hair loss. Initial endocrine tests revealed autoimmune hypothyroidism. An MRI of his pituitary gland at onset revealed hyperplasia. He tolerated replacement endocrine therapy with good response, but with no improvement in his alopecia universalis. A repeat MRI, 6 months after his initial endocrine manipulation, showed resolution of his pituitary hyperplasia.
Asunto(s)
Alopecia/etiología , Enfermedad de Hodgkin/complicaciones , Hipotiroidismo/etiología , Hipófisis/patología , Poliendocrinopatías Autoinmunes/diagnóstico , Adulto , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Bleomicina/uso terapéutico , Dacarbazina/uso terapéutico , Doxorrubicina/uso terapéutico , Enfermedad de Hodgkin/tratamiento farmacológico , Humanos , Hiperplasia , Hipotiroidismo/diagnóstico , Quimioterapia de Inducción , Masculino , Poliendocrinopatías Autoinmunes/complicaciones , Vinblastina/uso terapéuticoAsunto(s)
Infecciones del Sistema Respiratorio/microbiología , Respirovirus/aislamiento & purificación , Adolescente , Adulto , Anciano , Niño , Preescolar , Femenino , Humanos , Lactante , Masculino , Persona de Mediana Edad , Infecciones por Paramyxoviridae/epidemiología , Infecciones por Paramyxoviridae/inmunología , Trinidad y TobagoRESUMEN
A new infrared Thomson scattering system has been designed for the MAST tokamak. The system will measure at 120 spatial points with approximately 10 mm resolution across the plasma. Eight 30 Hz 1.6 J Nd:YAG lasers will be combined to produce a sampling rate of 240 Hz. The lasers will follow separate parallel beam paths to the MAST vessel. Scattered light will be collected at approximately f/6 over scattering angles ranging from 80 degrees to 120 degrees. The laser energy and lens size, relative to an existing 1.2 J f/12 system, greatly increases the number of scattered photons collected per unit length of laser beam. This is the third generation of this polychromator to be built and a number of modifications have been made to facilitate mass production and to improve performance. Detected scattered signals will be digitized at a rate of 1 GS/s by 8 bit analog to digital converters (ADCs.) Data may be read out from the ADCs between laser pulses to allow for real-time analysis.