Association between oxidative stress and temporomandibular joint dysfunction: A narrative review.

BACKGROUND: The role of oxidative stress in temporomandibular disorders (TMDs) has been studied using synovial fluid, to evaluate oxidative stress (im)balance and its potential role in the onset and/or progression of the disease. OBJECTIVE: This review aimed to evaluate the association between oxidative stress markers and the etiopathogenesis of TMJ dysfunction by means of synovial fluid analysis. METHODS: Two independent reviewers searched the electronic databases from inception to March 2019: PubMed/MEDLINE, LILACS, SciELO, EMBASE, TRIPDATABASE, SCOPUS, and Google Scholar. The following key search terms were used: Temporomandibular Joint Disorders OR Temporomandibular Joint Disc OR Temporomandibular Joint Dysfunction Syndrome OR Temporomandibular Joint OR Facial Pain AND Free Radicals OR Oxidative Stress. Data were extracted from the selected articles, including study design, sample profile, TMJ disease reported, diagnostic method, reactive oxygen and nitrogen species evaluated, enzymatic and non-enzymatic antioxidants evaluated, and techniques used to measure free radicals and antioxidants. RESULTS: After title and abstract screening of 6974 results, and full-text reading, 19 studies were included. All selected articles were cross-sectional observational studies. Enzymatic and non-enzymatic antioxidant defences appeared to be reduced in these patients, resulting in the establishment of the oxidative stress process. In addition, the studies showed a positive correlation between the severity of the intra-articular TMD and the increase in oxidative damage. CONCLUSION: The establishment of oxidative stress, whether by an increase in reactive oxygen/nitrogen species or by a decrease in antioxidant defences, or a combination of both, may be associated with the establishment and maintenance of intra-articular damage.

Effectiveness of the Distance Learning Strategy Applied to Orthodontics Education: A Systematic Literature Review.

Introduction: Tele-education refers to the use of interactive distance learning technologies. The objective of this systematic review was to evaluate the impact of tele-education in the field of orthodontics.Methods: This systematic review has been registered in PROSPERO and followed PRISMA guidelines. Two independent researchers reviewed the literature available in the databases of PubMed/MEDLINE, Bireme, the Cochrane Library, EMBASE, TRIP, SCIELO, LILAS, SCIENCEDIRECT, and Google Scholar using the following descriptors: "Education, Distance" OR "e-learning" AND "Orthodontics," including only interventional studies. The descriptive synthesis was conducted according to the Center for Reviews and Dissemination. The analysis of the biases was conducted using the MINORS protocol, and the analysis of the interventions using Kirkpatrick's method was evaluated.Results: Of the 15 remaining articles for complete reading, 4 were excluded for not meeting the inclusion criteria, leaving 11 articles for evaluation in the systematic review. Eight articles emphasized the evaluation of the distance education materials available, achieving a high percentage of acceptability among students, two cited only satisfaction, and one article evaluated the practical performance of the students.Conclusion: The results showed that orthodontic distance learning is an effective but complementary element, with no significant differences, to the traditional method of teaching.

Use of Dental Care Among Pregnant Women in the Brazilian Unified Health System.

PURPOSE: To assess the prevalence of and factors associated with the use of public Unified Health System-based dental services by pregnant women and recent mothers. MATERIALS AND METHODS: In this cross-sectional study, face to face interviews were conducted to collect data on the outcome of interest (prevalence of use of dental care) and independent variables (sociodemographic, pregnancy, and prenatal care data). A total of 302 pregnant women seen at public dental services in the municipality of Canoas, southern Brazil, were interviewed. Statistical analysis was performed using the chi-squared test and hierarchical Poisson regression with robust variance (p < 0.05). RESULTS: The prevalence of use of dental care among pregnant women was 50% (n = 151). Pregnant women who initiated prenatal care in the first trimester showed a 34% higher likelihood of using dental care (prevalence ratio [PR] 1.34; 95% confidence interval [95%CI] 1.27-1.61); this likelihood was 12% higher among multiparous women (PR 1.12; 95%CI 1.03-1.23), and 40% higher among women who received guidance to seek dental care (PR 1.40; 95%CI 1.30-1.51). CONCLUSION: The present findings suggest that starting prenatal care in the first trimester, being multiparous, and receiving guidance to seek dental care significantly contributed to the use of public dental services during pregnancy in the population assessed. These factors should be considered when planning public health policies for this population.

Pediatric Dentistry in Primary Healthcare: Creation, Development, and Evaluation of a Distance Education Course.

BACKGROUND: Oral health in childhood is a major problem for global public health. In Brazil, the prevalence of childhood tooth decay varies from 12% to 46%. Dental care treatment in Brazil is almost the exclusive responsibility of primary healthcare (PHC). Therefore, it is essential these professionals are prepared to conduct restorative, endodontic, and exodontic treatments and preventive care in children. INTRODUCTION: Children make up a large proportion of the population in territories requiring advanced dental care provided by PHC in Brazil. To care for these patients, it is necessary to have both manual dexterity and technical knowledge of pediatric dentistry. Accordingly, this study aimed to develop a distance course on pediatric dentistry. MATERIALS AND METHODS: A pretest questionnaire consisting of 15 questions was used to assess initial dental knowledge of participants. After completion of a five-module course, participants retook the same initial dental knowledge questionnaire (post-test). Descriptive statistic and paired t test, one-way analysis of variance, and Pearson and Spearman correlation were used, and a significance level of 5% was set. RESULTS: The majority of participants completing the five-module course were women who earned specialty degrees beyond undergraduate studies and currently worked in PHC (>5 years). Participant performance on the dental knowledge questionnaire after completion of the five-module course improved pre- to post-test. CONCLUSIONS: These data suggest that completion of a distance course on pediatric dentistry can be an effective tool for improving knowledge of pediatric dentistry in PHC professionals.

Functional recovery time after facial fractures: characteristics and associated factors in a sample of patients from southern Brazil.

Understanding the cause, severity, and elapsed time for the restoration of the functions of maxillofacial injuries can contribute to the establishment of clinical priorities aiming at effective treatment and further prevention of facial trauma. The objective of this study was to understand the factors associated with the restoration of mastication, ocular, and nasal functions in the face of trauma victims, estimating their recovery time after surgical treatment. We analyzed 114 medical records of patients treated at the Hospital Montenegro, who attended follow-up consultations for up to 180 days. For analysis of the recovery time, we performed survival analysis, followed by COX analysis. We observed that half of the patients recovered their functions within 20 days. The average time for recovery from trauma in the zygomatic-orbital-malar-nasal complex was 11 days, and in the maxillary-mandibular complex, 21 days (HR: 1.5 [0.99 2.3], p = 0.055). Although functional reestablishment has reached high rates after the surgical approach, it is necessary to analyze the failing cases, as well as the economic impacts and the prevention strategies associated with facial trauma, to improve the service to the population.

Functional recovery time after facial fractures: characteristics and associated factors in a sample of patients from southern Brazil.

Understanding the cause, severity, and elapsed time for the restoration of the functions of maxillofacial injuries can contribute to the establishment of clinical priorities aiming at effective treatment and further prevention of facial trauma. The objective of this study was to understand the factors associated with the restoration of mastication, ocular, and nasal functions in the face of trauma victims, estimating their recovery time after surgical treatment. We analyzed 114 medical records of patients treated at the Hospital Montenegro, who attended follow-up consultations for up to 180 days. For analysis of the recovery time, we performed survival analysis, followed by COX analysis. We observed that half of the patients recovered their functions within 20 days. The average time for recovery from trauma in the zygomatic-orbital-malar-nasal complex was 11 days, and in the maxillary-mandibular complex, 21 days (HR: 1.5 [0.99 2.3], p = 0.055). Although functional reestablishment has reached high rates after the surgical approach, it is necessary to analyze the failing cases, as well as the economic impacts and the prevention strategies associated with facial trauma, to improve the service to the population.

Impact of teleconsultations on the conduct of oral health teams in the Telehealth Brazil Networks Programme.

Telehealth has been applied in the Unified Health System (SUS) as a tool for qualifying professionals and improving the healthcare provided to the population served by the system. The aim of the present study was to evaluate the impact of teleconsultations on the qualifications of the clinical approach of the oral health teams involved in primary health care (PHC) in the state of Rio Grande do Sul under the Telehealth Brazil Networks Programme. The sample population of the study was composed of 285 dentists and 132 oral health assistants belonging to the Family Health Teams. A chi-square test was used to investigate possible associations between the absolute number of teleconsultations performed and several independent variables, namely, gender, age, dental specialty, time since graduation, time working in the Family Health Strategy (FHS), employment status, type of training institution, familiarity with information technology, and work satisfaction at the health facility. The level of significance was p < 0.05. Use of the oral health teleconsultation service led to a reduction of more than 45% in the number of referrals to other levels of care. However, no significant association was found between the number of teleconsultations and the independent variables analysed. The use of teleconsultations proved to be a powerful tool for professional training, for increasing the effectiveness of PHC, and for improving the oral healthcare provided.

Antimicrobial effect of photodynamic therapy on intracanal biofilm: A systematic review of in vitro studies.

BACKGROUND: Antimicrobial photodynamic therapy (A-PDT), is one of the adjunctive therapies developed to improve the effectiveness of root canal disinfection.. The aim of this study was to analyze the antimicrobial effect of PDT on intracanal biofilm. METHODS: Two reviewers conducted a literature search in PubMed, MEDLINE, Lilacs, SciELO, EMBASE and Google Scholar using the following search strategy: photochemotherapy "[Mesh] OR (photodynamic therapy) AND" dental plaque "[Mesh] OR (dental biofilm) AND (root canal). The following data were collected: publication year, author's name, study site, type of study, participant number, type of photosensitizer, type of laser, method of data collection, application time and results. Study quality was assessed using the Methodological Index for Non-Randomized Studies (MINORS). RESULTS: After selection based on title, abstract and full text, 27 studies were included in this systematic review. PDT reduced bacterial viability in most studies when combined with conventional endodontic techniques. CONCLUSION: PDT reduced bacterial counts in most studies, especially when used as an adjunct to the conventional endodontic technique to treat refractory infection. However, PDT effects on in vitro bacterial biofilm were not accurately quantified because of the numerous biases in the studies reviewed.

Rehabilitation of the Edentulous Mandible with an Immediately Loaded Full-Arch Fixed Prosthesis Supported by Three Implants: A 5-Year Retrospective Analysis.

PURPOSE: To evaluate the clinical and radiographic outcomes of full-arch mandibular rehabilitation with fixed prostheses supported by three immediately loaded implants after at least 5 years of follow-up. MATERIALS AND METHODS: The sample comprised 58 patients who underwent treatment with immediate loading. Radiographic evaluation of bone loss was carried out in Adobe Photoshop CS5 by a single calibrated examiner using digitized panoramic radiographs. Clinical examination of the technical conditions of the prosthetic device assessed the condition of the acrylic resin base, dental occlusion, metal framework, presence of cover screws, screw fixation of the prosthesis and abutments, and length of cantilever and resistance arms. RESULTS: Five implants in four patients failed, for an overall success rate of 97.13%. Mean bone loss was 2.65 ± 1.06 mm around central implants and 2.11 ± 0.84 mm around distal implants. The most common complication was loss of abutment torque. Half of all patients in the sample experienced some prosthetic complication. There was no evidence of a statistically significant relationship of cantilever length with bone loss or prosthetic complications. CONCLUSION: The immediately loaded three-implant-supported fixed prosthesis protocol tested in this study proved to be a viable therapeutic strategy for mandibular rehabilitation in edentulous patients, with favorable outcomes after 5 years of clinical and radiographic follow-up.

[Access to and use of oral health services among the elderly in Pelotas, Rio Grande do Sul State, Brazil]. / Acesso e utilização dos serviços de saúde bucal por idosos de Pelotas, Rio Grande do Sul, Brasil.

This article sought to measure lack of access and use of oral health services by elderly residents of Pelotas, Rio Grande do Sul State, Brazil. This is a cross-sectional population study carried out in 2014, in the city's urban zone, including individuals aged 60 years or more. Sociodemographic and self-reported needs variables were associated with outcomes. We used Poisson regression for the crude and adjusted analyses. We interviewed 1,451 elderly individuals using a structured questionnaire. The prevalence of lack of access in the previous year was of 1.8% (95%CI: 0.7-3.0). Elderly individuals who never had a consultation were 3.1% (95%CI: 2.2-4.0) and the prevalence of use of oral health services in the previous years was 38.3%(95%CI 36.0-41.0). Use in the previous year was positively associated with the following variables: younger age (PR = 1.16), having a partner (PR = 1.28), high educational level (PR = 1.31), mouth or teeth problems (PR = 1.93), need for dental prosthesis (PR = 1.36) and being edentulous (PR = 3.11). Lack of access in the previous year was low. Oral health service use was higher than that observed in other states. Findings seem to reflect the expansion of oral health services in the city, especially in the public network, and are useful for health policy planning.

O objetivo foi medir a falta de acesso e a utilização dos serviços de saúde bucal por idosos de Pelotas, Rio Grande do Sul, Brasil. Estudo transversal de base populacional foi realizado no ano de 2014, na zona urbana do município, incluindo indivíduos com 60 anos e mais. Variáveis sociodemográficas e de necessidade autorreferidas foram associadas aos desfechos. Utilizou-se regressão de Poisson para as análises bruta e ajustada. Foram entrevistados 1.451 idosos mediante um questionário estruturado. Falta de acesso no último ano alcançou uma prevalência de 1,8% (IC95%: 0,7-3,0). Idosos que nunca consultaram somaram 3,1% (IC95%: 2,2-4,0) e a utilização de serviços de saúde bucal no último ano registrou prevalência de 38,3% (IC95%: 36,0-41,0). A utilização no último ano apresentou associação positiva com as seguintes variáveis: faixa etária mais jovem (RP = 1,16), ter companheiro (RP = 1,28), alta escolaridade (RP = 1,31), problema na boca ou nos dentes (RP = 1,93), necessidade de prótese dentária (RP = 1,36) e ser edêntulo (RP = 3,11). A falta de acesso no último ano foi baixa. A utilização de serviços de saúde bucal foi mais alta do que a observada em outros estudos. Os achados parecem refletir a expansão desses serviços, particularmente na rede pública, sendo úteis para as ações de planejamento das políticas de saúde.

El objetivo fue medir la falta de acceso y utilización de los servicios de salud bucal por parte de ancianos en Pelotas, Río Grande do Sul, Brasil. Se realizó un estudio transversal de base poblacional durante el año 2014, en la zona urbana del municipio, incluyendo a individuos con 60 años y más. Las variables sociodemográficas y de necesidad autorreferidas se asociaron a los resultados. Se utilizó la regresión de Poisson para los análisis bruto y ajustado. Se entrevistaron a 1.451 ancianos, mediante un cuestionario estructurado. La falta de acceso en el último año alcanzó una prevalencia de 1,8% (IC95%: 0,7-3,0). Los ancianos que nunca consultaron sumaron un 3,1% (IC95%: 2,2-4,0) y la utilización de servicios de salud bucal en el último año tuvo una prevalencia de un 38,3% (IC95%: 36,0-41,0). La utilización durante el último año presentó una asociación positiva con las siguientes variables: franja de edad más joven (RP = 1,16), tener compañero (RP = 1,28), alta escolaridad (RP = 1,31), problema en la boca o en los dientes (RP = 1,93), necesidad de prótesis dental (RP = 1,36) y ser edéntulo (RP = 3,11). La falta de acceso en el último año fue baja. La utilización de servicios de salud bucal fue más alta que la observada en otros estudios. Los resultados parecen reflejar la expansión de los servicios de salud bucal en el municipio, particularmente en la red pública, siendo útiles para las acciones de planificación dentro de las políticas de salud.

Impacts of Orthognathic Surgery on Patient Satisfaction, Overall Quality of Life, and Oral Health-Related Quality of Life: A Systematic Literature Review.

Several treatments have been suggested to correct dentofacial abnormalities, including orthognathic surgery. The aim of the present systematic review was to assess the impact of orthognathic surgery on patient satisfaction, overall quality of life, quality of life related to oral health-and to orthognathic surgery in particular-among adult patients. Two investigators independently reviewed the available literature in the databases PubMed/MEDLINE, LILACS, SciELO, EMBASE, Trip, and Google Scholar (gray literature) based on the keywords "orthognathic surgery" and "quality of life." An analysis of bias was performed based on the MINORS (methodological index for nonrandomized studies). A total of 245 relevant studies were retrieved from the databases, and 6 additional studies were located after a manual search of the references. Following selection based on titles, abstracts, and full-text analysis, 30 studies were included in the present systematic review. To evaluate quality of life before and after orthognathic surgery, 12 studies applied the surgery-related Orthognathic Quality of Life Questionnaire (OQLQ), 12 used the Oral Health Impact Profile (OHIP-14), and 4 used the Short Form Health Survey (SF-36). Orthognathic surgery results in improvements in quality of life both physically and psychosocially after surgery and is associated with high rates of patient satisfaction.

Performance of primary healthcare dentists in a distance learning course in pediatric dentistry.

OBJECTIVE: Children are an important portion of the population of the territories covered by Primary Health Care (PHC), with needs and characteristics that can be managed at this level of care. Therefore, it is essential that professionals working in PHC be capable of providing child care. The aim of this study was to evaluate the performance of dentists working in primary healthcare (PHC) in a pediatric dentistry distance learning (DL) course, and to investigate the relationship between the grades earned on questionnaires applied after each course module and features of their personal and professional profile. METHOD: The study used a convenience sample of 201 dentists working in PHC, who enrolled in a DL course offered by a telehealth center in the state of Rio Grande do Sul, Brazil. The course consisted of video classes on restorative dentistry, endodontics, dental trauma, and clinical management in pediatric dentistry. After completing each module, each participant was asked to answer a questionnaire to assess their acquisition of immediate knowledge. Student's t-test and the ANOVA test were used to assess the relationship between the mean grade earned and the variables of sex, age, type of training institution, time since graduation, and years working in PHC. RESULTS: A significant relationship was observed between type of training institution (public) and the grade earned on the restorative dentistry questionnaire, and also between time since graduation and the grade earned on the dental trauma questionnaire (p < 0.05). No relationship was observed between the personal/professional variables and the grades earned on the endodontics and clinical management questionnaires. Grades were significantly lower on the endodontics questionnaire (p < 0.05). DISCUSSION: The large number of dentists enrolled in this DL course is a demonstration that there is great interest in pediatric dentistry contents. Improvement of DL courses may lead to the enhancement of professionals and their skills, and to a significant improvement in the quality of care provided to children in public health networks. CONCLUSION: It was concluded that training in a public institution and a longer time since graduation positively influenced the grades earned on the restorative dentistry and dental trauma questionnaires, respectively.

Satisfaction of Primary Healthcare Dentists after the Completion of a Distance Learning Course in Pediatric Dentistry.

BACKGROUND: The aim of the present study was to assess the level of satisfaction of dentists working in primary healthcare (PHC) with a Distance learning (DL) course in pediatric dentistry offered by the TeleHealthRS center, and to the investigate possible associations between the variables indicative of their satisfaction and their performance on the questionnaires applied before and after the course. METHODS: The course was offered in 2015 by the Federal University of Rio Grande do Sul (UFRGS) together with the TeleHealthRS center in Brazil. Data were collected on the participants' personal and professional profile, their pre- and post-course knowledge about pediatric dentistry, and their satisfaction with the course. Student's t-test and the ANOVA test were used to assess the possible associations between the variables indicative of their satisfaction and their performance on the questionnaires applied before and after the course. RESULTS: Overall, the participants were satisfied with the course, however, no statistically significant association was found between the variables indicative of their satisfaction and the grades they earned on the pre- and post-course questionnaires. CONCLUSION: The available pediatric dentistry course received positive evaluations from the participants, constituting a possible strategy for the qualification of primary care dentists. Future studies are warranted to further investigate the expectations of DL course participants, aiming to enhance the quality of future editions of this learning modality for pediatric dentistry contents.

Biochemical effects of pretreatment with vitamins E and C in rats submitted to intrastriatal hypoxanthine administration.

We previously demonstrated that intrastriatal injection of hypoxanthine, the major metabolite accumulating in Lesch-Nyhan disease, inhibited Na+,K+-ATPase activity and induced oxidative stress in rat striatum. In the present study, we evaluated the action of vitamins E and C on the biochemical alteration induced by hypoxanthine administration on Na+,K+-ATPase, TBARS, TRAP, as well as on superoxide dismutase (SOD), catalase (CAT) and glutathione-peroxidase (GPx) activities in striatum of adult rats. Animals received pretreatment with vitamins E and C or saline during 7 days. Twelve hours after the last injection of vitamins or saline, animals were divided into two groups: (1) vehicle-injected group and (2) hypoxanthine-injected group. For all parameters investigated in this research, animals were sacrificed 30 min after drug infusion. Results showed that pretreatment with vitamins E and C prevented hypoxanthine-mediated effects on Na+,K+-ATPase, TBARS and antioxidant enzymes (SOD, CAT and GPx) activities; however the reduction on TRAP was not prevented by these vitamins. Although extrapolation of findings from animal experiments to humans is difficult, it is conceivable that these vitamins might serve as an adjuvant therapy in order to avoid progression of striatal damage in patients affected by Lesch-Nyhan disease.

Intrastriatal injection of hypoxanthine impairs memory formation of step-down inhibitory avoidance task in rats.

The aim of this study was to investigate the effects of intrastriatal injection of hypoxanthine, the major compound accumulated in Lesch-Nyhan disease, on performance step-down inhibitory avoidance task in the rat. Male adult Wistar rats were divided in two groups: (1) saline-injected and (2) hypoxanthine-injected group. Treated-group received intrastriatal hypoxanthine solution 30 min before training session (memory acquisition) or immediately after training session (memory consolidation) or 30 before test session (memory retrieval) on step-down inhibitory avoidance task. Results show that hypoxanthine administration caused significant memory impairment in all periods tested. These results show that intrastriatal hypoxanthine administration provoked memory process impairment of step-down inhibitory avoidance task, an effect that might be related to the cognitive memory alterations in Lesch-Nyhan patients.

Proporções de procedimentos odontológicos realizados no município de canoas: um histórico de 10 anos / Rate of procedure performed by dental services municipality of Canoas: a history 10 years

RESUMO Os objetivos do presente estudo foram: realizar uma série histórica dos procedimentos realizados pelos serviços odontológicos na Atenção Primária em Saúde (APS) no município de Canoas e verificar a redução da proporção de procedimentos de exodontia. Os dados foram coletados do Departamento de Informática do SUS (DATASUS) e foram agrupados em blocos de procedimentos odontológicos: exodontias, restauradores, preventivos, periodontais, endodônticos/urgências e outros procedimentos. Verificou-se que houve redução da proporção de exodontias e quando foram calculadas as médias do período de 10 anos, utilizando os critérios específicos da APS e do IDSUS, as proporções de exodontias foram 4,46% e 4,83%. Neste contexto, conclui-se que a série histórica evidencia a redução das proporções de exodontias no município e as médias das proporções das exodontias no período avaliado foram maiores quando comparadas com a meta estabelecida pelo Plano Anual de Saúde (2,8)

ABSTRACT The objectives of the present study were to perform a historical series of procedures performed by dental services in Primary Health Care (PHC) in the city of Canoas and to verify the reduction in the rate of extraction procedures. The data were collected from the SUS Informatics Department (DATASUS) and were grouped into blocks of dental procedures: extraction, restorative, preventive, periodontal, endodontic / urgency and other procedures. It was found that there was a reduction in the rate of extraction and when the averages of the 10-year period were calculated using the specific criteria of PHC and IDSUS, the rates of extraction were 4.46 and 4.83. In this context, it can be concluded that the historical series shows the reduction of extraction rates in the municipality, however, the average rates of extraction rates in the evaluated period were high when compared to the target established by the Annual Health Plan (2.8)

Epidemiological study of facial fractures at the Oral and Maxillofacial Surgery Service, Santa Casa de Misericordia Hospital Complex, Porto Alegre - RS - Brazil.

OBJECTIVES: to investigate the incidence and etiology of face trauma with diagnosis of facial fracture treated at the Buccomaxillofacial Surgery and Traumatology Service of the Santa Casa de Misericórdia Hospital Complex in Porto Alegre. METHODS: we conducted a cross-sectional, retrospective epidemiological study of 134 trauma victims with 153 facial fractures. RESULTS: the male gender was the most affected (86.6%) and the incidence was higher in the age group from 21 to 30 years. The main etiology was assault (38.8%), followed by motor vehicle accidents (14.2%), motorcycle accidents (13.4%), falls (9%), road accidents (6.7%), sports accidents (5.2%), work accidents (5.2%), firearm injuries (4.5%) and cycling accidents (3%). The most frequent fractures were those of the zygomatic complex (44.5%), followed by fractures of the mandible (42.5%), maxillary bone (5.2%), nasal bones (4.5%) and zygomatic arch (3.3%). CONCLUSION: the fractures of the zygomatic complex and the mandible were the ones with the highest incidence in the facial traumas, having physical assaults as their main cause.

Intrastriatal hypoxanthine administration affects Na+,K+-ATPase, acetylcholinesterase and catalase activities in striatum, hippocampus and cerebral cortex of rats.

The aim of this study was to investigate the effects of a single intrastriatal injection of hypoxanthine, the major metabolite accumulating in Lesch-Nyhan disease, on Na(+),K(+)-ATPase, acetylcholinesterase and catalase activities in striatum, cerebral cortex and hippocampus of rats at different post-infusion periods. Adult Wistar rats were divided in two groups: (1) vehicle-injected group (control) and (2) hypoxanthine-injected group. For Na(+),K(+)-ATPase activity determination, the animals were sacrificed 3h, 24h and 7 days after drug infusion. For the evaluation of acetylcholinesterase and catalase activities, the animals were sacrificed 30min, 3h, 24h and 7 days after hypoxanthine infusion. Results show regional and time dependent effects of hypoxanthine on Na(+),K(+)-ATPase, acetylcholinesterase and catalase activities. The in vitro effect of hypoxanthine on the same enzymes in striatum was also investigated. Results showed that hypoxanthine inhibited Na(+),K(+)-ATPase, but not the activities of acetylcholinesterase and catalase in rat striatum. We suggest that these modification on cerebral biochemical parameters (Na(+),K(+)-ATPase, acetylcholinesterase and catalase activities) induced by intrastriatal administration of hypoxanthine in all cerebral structures studied, striatum, hippocampus and cerebral cortex, could be involved in the pathophysiology of Lesch-Nyhan disease.

Prevalence of temporomandibular dysfunction in athletes: integrative review / Prevalência da disfunção temporomandibular em atletas: revisão integrativa

ABSTRACT BACKGROUND AND OBJECTIVES: Temporomandibular disorder is considered to be a set of clinical manifestations that affect the masticatory muscles, the temporomandibular joint and adjacent structures, whose signs and symptoms can negatively impact the quality of life of their patients. A population group in which the prevalence of temporomandibular disorder has increased in recent years is that of athletes. The aim of the present study was to conduct an integrative literature review to verify the prevalence of temporomandibular disorders in athletes, as well as factors related to their predisposition. CONTENTS: The searches were performed in the Medline, LILACS and Scielo databases, using the descriptors "temporomandibular joint", "athletic injuries" and "temporomandibular disease". Inclusion criteria were researches derived from primary data regardless of design, which was the target audience of athletes and that addressed the presence of temporomandibular joint or muscle dysfunction. Ten studies were selected and included in the review. The results obtained with the analysis of these articles showed that athletes are subject to temporomandibular disorders not only due to injuries suffered during competitions, but also due to factors associated with stress and the use of specific devices for sports practice. CONCLUSION: The occurrence of temporomandibular disorders is common among athletes, but can be avoided with the use of preventive measures and conservative treatments. Dental monitoring is essential for these professionals to perform well, preventing the occurrence of temporomandibular disorders or treating them when they occur.

RESUMO JUSTIFICATIVA E OBJETIVOS: A disfunção temporomandibular é considerada um conjunto de alterações que acometem os músculos mastigatórios, articulação temporomandibular e estruturas adjacentes, os quais podem impactar negativamente na qualidade de vida dos seus portadores. Um grupo populacional no qual a prevalência de disfunção temporomandibular tem aumentado nos últimos anos é o de atletas. Assim, o objetivo do presente estudo foi realizar uma revisão integrativa da literatura a fim de verificar a prevalência das disfunções temporomandibulares em atletas, bem como os fatores relacionados a sua predisposição. CONTEÚDO: As buscas foram realizadas nas bases de dados Medline, LILACS e Scielo, utilizando os descritores "temporomandibular joint", "athletic injuries" e "temporomandibular disease". Os critérios de inclusão foram pesquisas oriundas de dados primários com qualquer delineamento; tendo como público-alvo os atletas e que abordassem a presença de disfunção temporomandibular articular ou muscular. Foram selecionados 10 estudos que foram incluídos nesta revisão. Os resultados obtidos com as análises dos artigos evidenciaram que atletas estão sujeitos às disfunções temporomandibulares não somente pelas lesões sofridas durante as competições, mas também por fatores associados ao estresse e ao uso de dispositivos específicos da prática desportiva. CONCLUSÃO: A ocorrência de disfunções temporomandibulares é comum entre atletas, mas elas podem ser evitadas com a utilização de medidas preventivas e tratamentos conservadores. O acompanhamento odontológico é fundamental para prevenir ou tratar a disfunção temporomandibular.

Functional recovery time after facial fractures: characteristics and associated factors in a sample of patients from southern Brazil / Tempo de recuperação funcional após fraturas faciais: perfil e fatores associados em amostra de pacientes do sul do Brasil

ABSTRACT Understanding the cause, severity, and elapsed time for the restoration of the functions of maxillofacial injuries can contribute to the establishment of clinical priorities aiming at effective treatment and further prevention of facial trauma. The objective of this study was to understand the factors associated with the restoration of mastication, ocular, and nasal functions in the face of trauma victims, estimating their recovery time after surgical treatment. We analyzed 114 medical records of patients treated at the Hospital Montenegro, who attended follow-up consultations for up to 180 days. For analysis of the recovery time, we performed survival analysis, followed by COX analysis. We observed that half of the patients recovered their functions within 20 days. The average time for recovery from trauma in the zygomatic-orbital-malar-nasal complex was 11 days, and in the maxillary-mandibular complex, 21 days (HR: 1.5 [0.99 2.3], p = 0.055). Although functional reestablishment has reached high rates after the surgical approach, it is necessary to analyze the failing cases, as well as the economic impacts and the prevention strategies associated with facial trauma, to improve the service to the population.

RESUMO O entendimento da causa, da gravidade e do tempo decorrido para o restabelecimento das funções de lesões maxilofaciais pode contribuir para o estabelecimento de prioridades clínicas objetivando o efetivo tratamento e prevenção dos traumatismos de face. Assim, o objetivo deste estudo foi compreender quais os fatores associados ao restabelecimento das funções mastigatórias, oculares e nasais em vítimas de trauma de face, estimando o tempo para recuperação das funções, após o tratamento cirúrgico. Foram analisados 114 prontuários de pacientes atendidos no Hospital de Montenegro que compareceram às consultas de acompanhamento por até 180 dias. Para a análise do tempo para a recuperação, foi realizada a análise de sobrevida, seguida da análise de COX. Observou-se que metade dos pacientes recuperaram as funções em até 20 dias, sendo que o tempo médio para recuperação dos traumas no complexo zigomático-orbitário-malar-nasal foi de 11 dias e do complexo maxilo - mandibular de 21 dias (HR: 1,5 (0,99 - 2,3) p=0,055). Embora o restabelecimento das funções tenha atingido taxas elevadas após abordagem cirúrgicas, faz-se necessária a análise dos casos de insucessos bem como os impactos econômicos e as estratégias de prevenção associados aos traumas de face a fim de qualificar o serviço prestado à população.