RESUMEN
Extracorporeal circulation using heart-lung-machines is associated with a profound activation of corpuscular and plasmatic components of circulating blood, which can also lead to deleterious events such as systemic inflammatory response and hemolysis. Individual components used to install the extracorporeal circulation have an impact on the level of activation, most predominantly membrane oxygenators and hardshell venous reservoirs as used in extracorporeal systems. The blood flows in two different hardshell reservoirs are computationally investigated. A special emphasis is placed on the prediction of an onset of transition and turbulence generation. Reynolds-averaged numerical simulations (RANS) based on a transitional turbulence model, as well as large eddy simulations (LES) are applied to achieve an accurate prediction. In the LES analysis, the non-Newtonian behavior of the blood is considered via the Carreau model. Blood damage potential is quantified applying the Modified Index of Hemolysis (MIH) based on the predicted flow fields. The results indicate that the flows in both reservoirs remain predominantly laminar. For one of the reservoirs, considerable turbulence generation is observed near the exit site, caused by the specific design for the connection with the drainage tube. This difference causes the MIH of this reservoir to be nearly twice as large as compared to the alternative design. However, a substantial improvement of these performance criteria can be expected by a local geometry modification.
Asunto(s)
Puente Cardiopulmonar/instrumentación , Modelos Teóricos , Hemodinámica , HumanosRESUMEN
Neurologic complications during on-pump cardiovascular surgery are often induced by mobilization of atherosclerotic plaques, which is directly related to enhanced wall shear stress. In the present study, we numerically evaluated the impact of dispersive aortic cannulas on aortic blood flow characteristics, with special regard to the resulting wall shear stress profiles. An idealized numerical model of the human aorta and its branches was created and used to model straight as well as bent dispersive aortic cannulas with meshlike tips inserted in the distal ascending aorta. Standard cannulas with straight beveled or bent tips served as controls. Using a recently optimized computing method, simulations of pulsatile and nonpulsatile extracorporeal circulation were performed. Dispersive aortic cannulas reduced the maximum and average aortic wall shear stress values to approximately 50% of those with control cannulas, while the difference in local values was even larger. Moreover, under pulsatile circulation, dispersive cannulas shortened the time period during which wall shear stress values were increased. The turbulent kinetic energy was also diminished by utilizing dispersive cannulas, reducing the risk of hemolysis. In summary, dispersive aortic cannulas decrease aortic wall shear stress and turbulence during extracorporeal circulation and may therefore reduce the risk of endothelial and blood cell damage as well as that of neurologic complications caused by atherosclerotic plaque mobilization.
Asunto(s)
Aorta/fisiopatología , Cateterismo Cardíaco/métodos , Circulación Extracorporea/efectos adversos , Placa Aterosclerótica/cirugía , Resistencia al Corte/fisiología , Velocidad del Flujo Sanguíneo , Cateterismo Cardíaco/instrumentación , Circulación Extracorporea/métodos , Hemodinámica/fisiología , Humanos , Modelos Cardiovasculares , Placa Aterosclerótica/fisiopatología , Flujo Pulsátil , Valores de Referencia , Reproducibilidad de los Resultados , Estrés MecánicoRESUMEN
This study aims to optimize the power generation of a conventional Manzanares solar chimney (SC) plant through strategic modifications to the collector inlet height, chimney diameter, and chimney divergence. Employing a finite volume-based solver for numerical analysis, we systematically scrutinize influential geometric parameters, including collector height (hi = 1.85 to 0.1 m), chimney inlet diameter (dch = 10.16 to 55.88 m), and chimney outlet diameter (do = 10.16 to 30.48 m). Our findings demonstrate that reducing the collector inlet height consistently leads to increased power output. The optimal collector inlet height of hi = 0.2 m results in a significant power increase from 51 to 117.42 kW (~ 2.3 times) without additional installation costs, accompanied by an efficiency of 0.25%. Conversely, enlarging the chimney diameter decreases the chimney base velocity and suction pressure. However, as turbine-driven power generation rises, the flow becomes stagnant beyond a chimney diameter of 45.72 m. At this point, power generation reaches 209 kW, nearly four times greater than the Manzanares plant, with an efficiency of 0.44%. Nevertheless, the cost of expanding the chimney diameter is substantial. Furthermore, the impact of chimney divergence is evident, with power generation, collector efficiency, overall efficiency, and collector inlet velocity all peaking at an outer chimney diameter of 15.24 m (corresponding to an area ratio of 2.25). At this configuration, power generation increases to 75.91 kW, approximately 1.5 times more than the initial design. Remarkably, at a low collector inlet height of 0.2 m, combining it with a chimney diameter of 4.5 times the chimney inlet diameter (4.5dch) results in an impressive power output of 635.02 kW, signifying a substantial 12.45-fold increase. To model the performance under these diverse conditions, an artificial neural network (ANN) is effectively utilized.
RESUMEN
Bioconvective heat and mass transport phenomena have recently been the subject of interest in diverse fields of applications pertaining to the motion of fluids and their thermophysical properties. The transport processes in a system involving triple convective phenomena, irregular geometry, and boundary conditions constitute a complex phenomenon. This work aims to explore the mixed thermo-bioconvection of magnetically susceptible fluid containing copper nanoparticles and oxytactic bacteria in a novel W-shaped porous cavity. The buoyant convention is generated due to the isothermal heating at the wavy bottom wall, whereas the mixed convection is induced due to the shearing motion of the top-cooled sliding wall. Furthermore, the bioconvection is induced due to the manifestation of oxytactic bacteria or organisms. The inclined sidewalls are insulated. The geometry is packed with water based Cu nanoparticle mixed porous structure, which is subjected to a magnetizing field acted horizontally. The complex transport equations are transformed into nondimensional forms, which are then computed using the finite volume-based developed code. The coupled triple-convective flow physics are explored for a wide range of involved controlling parameters, which could provide helpful insight to the system designer for its proper operation. The shape of geometry can be considered one of the important parameters to control the heat and mass transport phenomena. In general, the influence of amplitude (δ) is more compared to the waviness number (m) of the undulations. The magnitude of heat (Nu) and mass (Sh) transfer rate for the W-shaped cavity is high compared to conventional square and trapezoidal-shaped cavities. The output of the analysis could be very helpful for the designer for modeling devices operating on nanotechnology-based bioconvection, microbial fuel cells, and others.
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Convección , Nanotecnología , Porosidad , Calor , BacteriasRESUMEN
BACKGROUND AND OBJECTIVE: Mortality rate increases globally among which one third is due to diseased blood vessels. Due to late diagnoses of the disease in vessels (severe stenoses), qualitative and rapid assessment becomes difficult. Earlier assessment of stenoses can lead to formulation of effective treatment protocol. It is often found that proliferation of secondary stenoses at downstream of a stenosed vessel depends on the degree of severity of primary stenoses. Numerical investigation of flow dynamics of blood in such condition helps in prediction of distributed field of secondarystenoses. This investigation also requires consideration of rigorous boundary conditions at inlet and outlet of defined flow domain. METHODS: Patient-specific geometry of aortic arch with stenoses in descending aorta was considered for numerical estimation of biofluid dynamics. Boundary conditionsat inlet and outlet were extracted from time-resolved pulsed Doppler Ultrasound imaging at appropriate sections of the vessel. Womersley inlet flux was considered. Flow parameters like wall shear stress, oscillatory shear index, etc. were evaluated at upper and lower aortic arch of the vessel at different combinations of boundary conditions at inlet and four outlets respectively. RESULTS: Effect of outlet boundary conditions were acknowledged for the progression of secondary stenoses. Severity of primary stenoses was found influencing the progression of secondary stenoses. It was found that the outlets Left Subclavian Artery and Left Common Carotid Artery greatly influence the flow dynamic structure within the stenosed aortic arch. Simultaneously, lower wall of aortic-arch had shown more affinity for secondary stenoses progression. CONCLUSION: Aortic arch is a vital anatomical region of circulatory system which is vulnerable to progression of secondary stenoses in presence of primary stenoses in ascending or descending aorta. It also drives the author to speculate the influence of anurysm in descending aorta on this landmark of aortic arch.
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Arterias/fisiopatología , Constricción Patológica , Hemodinámica , Velocidad del Flujo Sanguíneo , Simulación por Computador , HumanosRESUMEN
Controversy on superiority of pulsatile versus non-pulsatile extracorporeal circulation in cardiac surgery still continues. Stroke as one of the major adverse events during cardiopulmonary bypass is, in the majority of cases, caused by mobilization of aortic arteriosclerotic plaques that is inducible by pathologically elevated wall shear stress values. The present study employs computational fluid dynamics to evaluate the aortic blood flow and wall shear stress profiles under the influence of antegrade or retrograde perfusion with pulsatile versus non-pulsatile extracorporeal circulation. While, compared to physiological flow, a non-pulsatile perfusion resulted in generally decreased blood velocities and only moderately increased shear forces (48 Pa versus 20 Pa antegradely and 127 Pa versus 30 Pa retrogradely), a pulsatile perfusion extensively enhanced the occurrence of turbulences, maximum blood flow speed and maximum wall shear stress (1020 Pa versus 20 Pa antegradely and 1178 Pa versus 30 Pa retrogradely). Under these circumstances arteriosclerotic embolism has to be considered. Further simulations and experimental work are necessary to elucidate the impact of our findings on the scientific discourse of pulsatile versus non-pulsatile extracorporeal circulation.