Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 3 de 3
Filtrar
Más filtros

Bases de datos
Tipo del documento
País de afiliación
Intervalo de año de publicación
1.
J Lipid Res ; 46(7): 1539-47, 2005 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-15834122

RESUMEN

The present study was undertaken to investigate the effect of cholesterol-enriched casein (CAS) and blue lupin seed (BL) diets on the cholesterol metabolism of intact (INT) and ileorectal anastomosed (IRA) pigs. For 3 weeks, four groups of six pigs were allocated to the treatments (CAS-INT, CAS-IRA, BL-INT, and BL-IRA). Diet-induced hypercholesterolemia was inhibited by the BL through a substantial decrease in plasma LDL-cholesterol. The BL also reduced liver esterified and total cholesterol, increased hepatic LDL receptor synthesis and HMG-CoA reductase activity, and stimulated intestinal bile acid reabsorption. The neutral sterol output was higher in BL- than in CAS-fed pigs. The bile acid output was lower in IRA than in INT pigs. Surgery also prevented steroid microbial transformation, but it did not influence plasma cholesterol levels. These results suggest that the hypocholesterolemic effect of the BL, compared with the CAS, is attributable to impaired intestinal cholesterol absorption, probably involving increased bile acid reabsorption and higher contents of dietary phytosterols, both factors that reduce the micellar solubilization of cholesterol. Furthermore, according to our data, the contribution of the large intestine to cholesterol metabolism is very weak.


Asunto(s)
Anticolesterolemiantes/farmacología , Íleon/cirugía , Lupinus/química , Recto/cirugía , Semillas/química , Anastomosis Quirúrgica , Animales , Bilis/química , Bilis/metabolismo , Ácidos y Sales Biliares/metabolismo , Colesterol en la Dieta/administración & dosificación , Colesterol en la Dieta/metabolismo , Dieta , Heces/química , Absorción Intestinal/efectos de los fármacos , Lípidos/sangre , Masculino , Porcinos
2.
J Nutr ; 134(12): 3305-12, 2004 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-15570030

RESUMEN

Previous studies demonstrated the cholesterol-lowering effect of dietary legumes (mainly soybeans) in animals and humans, but the mechanisms by which they exert this effect are not completely understood. The contribution of the hindgut to this hypocholesterolemic effect is also not well documented. The present work was undertaken to investigate the effect of cholesterol-enriched (2.8 g/kg) casein (C) and raw pea seed (RP) diets on the cholesterol metabolism of intact (I) and ileorectal anastomosed (IRA) growing pigs. Four groups of 6 pigs were allocated to the treatments (C-I, C-IRA, RP-I, and RP-IRA pigs) for 3 wk. Plasma total cholesterol was lowered by the RP diet through a significant decrease in LDL cholesterol. The RP diet also decreased the hepatic concentration of esterified cholesterol and increased 3-hydroxy-3-methylglutaryl CoA reductase activity and LDL receptor synthesis. The biliary total cholesterol and bile acid concentrations were greater in RP- than in C-fed pigs. In addition, fecal bile acid output was higher in RP-fed pigs. The cecum-colon by-pass inhibited cholesterol and beta-sitosterol microbial transformation, lowered the bile acid output, and increased the primary to secondary bile acid output ratio, but its influence on cholesterolemia was negligible. These results suggest a hypocholesterolemic effect of the raw pea diet probably due to increased fecal bile acid output and an increased biliary bile acid concentration.


Asunto(s)
Ésteres del Colesterol/metabolismo , Colesterol en la Dieta/farmacología , LDL-Colesterol/sangre , Colesterol/sangre , Dieta , Íleon/cirugía , Hígado/metabolismo , Pisum sativum , Recto/cirugía , Anastomosis Quirúrgica , Animales , Masculino , Valores de Referencia , Porcinos
3.
Br J Nutr ; 91(5): 689-98, 2004 May.
Artículo en Inglés | MEDLINE | ID: mdl-15137920

RESUMEN

The importance of legume proteins in cholesterol metabolism has been recognised, but the hindgut contribution is still unclear. The present work was undertaken to address the role of the caecum-colon in cholesterol metabolism in intact (I) and ileo-rectal anastomosed (IRA) pigs fed with casein or extruded soyabean (ES) diets. Four groups of six growing pigs were assigned to the treatments (casein-I, casein-IRA, ES-I, ES-IRA) for 3 weeks. Plasma total cholesterol, LDL- and HDL-cholesterol were not modified by surgery or diet. In the liver, the ES diet significantly depressed non-esterified, esterified and total cholesterol. The treatments did not affect hepatic 3-hydroxy-3-methylglutaryl CoA reductase, cholesterol 7alpha-hydroxylase or sterol 27-hydroxylase activities. In the gallbladder bile of ES-fed pigs, total cholesterol was depressed while total bile acid concentration was increased. IRA and the ES diet markedly decreased the biliary bile acid microbial metabolites (namely hyodeoxycholic acid) and increased the primary bile acids (mainly hyocholic acid). The concentration of bile hydrophobic acids was decreased only by the ES diet. Faecal neutral sterol output was increased in ES-fed pigs, but the bile acid and the sum of neutral and acidic steroid outputs were not. Microbial transformation of neutral and acidic steroids was markedly reduced by IRA, especially in the ES-fed pigs. Thus, surgery and ES modulated the steroid profile but the caecum-colon did not seem to play a crucial role in determining cholesterolaemia in pigs.


Asunto(s)
Caseínas/administración & dosificación , Colesterol/metabolismo , Proteínas en la Dieta/administración & dosificación , Glycine max , Íleon/cirugía , Recto/cirugía , Anastomosis Quirúrgica/métodos , Animales , Bilis/metabolismo , Ácidos y Sales Biliares/metabolismo , Ciego/metabolismo , Colesterol/sangre , HDL-Colesterol/sangre , LDL-Colesterol/sangre , Colon/metabolismo , Vesícula Biliar/metabolismo , Hígado/metabolismo , Masculino , Tamaño de los Órganos , Esteroides/metabolismo , Porcinos
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA